Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs.

Sanz MT, Campos C, Milani M, Foyaca M, Lamy A, Kurdian K, Trullas C

Journal of cosmetic dermatology1 Oct 2015Cited by 15 (Europe PMC)

PMID26424007DOI10.1111/jocd.12173PepBankPUB-26424007

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Palmitoyl tripeptide-38.

01HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
In women with sensitive skin, the multi-active serum showed an anti-wrinkle effect in 71%.
In plain wordsThe multi-active serum showed a wrinkle benefit in women with sensitive skin.
Peptide
Palmitoyl tripeptide-38
Outcome
Not applicableAnti-wrinkle response
Study
n = 32
Outcome group
Skin and hair · Skin and wound
Measurements
Women with anti-wrinkle effect
71%
women with sensitive skin, multi-active serum
Source sentences
Summary
The clinical study shows a relevant anti-wrinkle effect in 71% of the treated women with visible effects in 68% of the subjects as soon as 7 days of treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
In addition we evaluated the anti-ageing in vivo effect of this new serum applied on the face twice daily for 28 consecutive days and assessed by clinical and instrumental evaluation in 32 women with sensitive skin bearing wrinkles on crow's feet.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400708
02HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
In women with sensitive skin, visible effects of the multi-active serum occurred in 68% after 7 days.
In plain wordsWomen with sensitive skin showed visible effects after using the multi-active serum.
Peptide
Palmitoyl tripeptide-38
Outcome
Not applicableVisible response after 7 days
Study
n = 32
Outcome group
Skin and hair · Skin and wound
Measurements
Subjects with visible effects by 7 days
68%
women with sensitive skin, multi-active serum, 7 days
Source sentences
Summary
The clinical study shows a relevant anti-wrinkle effect in 71% of the treated women with visible effects in 68% of the subjects as soon as 7 days of treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
In addition we evaluated the anti-ageing in vivo effect of this new serum applied on the face twice daily for 28 consecutive days and assessed by clinical and instrumental evaluation in 32 women with sensitive skin bearing wrinkles on crow's feet.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400709
03HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
In women with sensitive skin, the multi-active serum significantly increased dermal density.
In plain wordsThe multi-active serum increased skin density in women with sensitive skin.
Peptide
Palmitoyl tripeptide-38
Outcome
IncreaseDermal density
Study
n = 32
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
A significant increase in dermal density and skin elasticity was also observed.
2 context sentences(design, population, supporting numbers)
Summary · context
In addition we evaluated the anti-ageing in vivo effect of this new serum applied on the face twice daily for 28 consecutive days and assessed by clinical and instrumental evaluation in 32 women with sensitive skin bearing wrinkles on crow's feet.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400710
04HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
In women with sensitive skin, the multi-active serum significantly increased skin elasticity.
In plain wordsThe multi-active serum increased skin elasticity in women with sensitive skin.
Peptide
Palmitoyl tripeptide-38
Outcome
IncreaseSkin elasticity
Study
n = 32
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
A significant increase in dermal density and skin elasticity was also observed.
2 context sentences(design, population, supporting numbers)
Summary · context
In addition we evaluated the anti-ageing in vivo effect of this new serum applied on the face twice daily for 28 consecutive days and assessed by clinical and instrumental evaluation in 32 women with sensitive skin bearing wrinkles on crow's feet.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400711
05LabNot a test of Palmitoyl tripeptide-38 aloneIn vitro (cells)Efficacy outcome
In human fibroblasts, the multi-active serum at 0.1% significantly increased oxygen consumption.
In plain wordsIn cells, the multi-active serum at 0.1% increased oxygen use.
Peptide
Palmitoyl tripeptide-38
Outcome
IncreaseOxygen consumption at 0.1%
Study
humann: not reported in source
senescent cultured fibroblasts
Outcome group
Mitochondrial function · Aging and longevity
Source sentences
Summary
The tested serum both at 0.1% and 1% induces a significant increase in 02 consumption, cellular ATP level and a reduction in extra-cellular lactate concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of the serum on the mitochondrial ROS (reactive oxygen species) production in human senescent cultured fibroblasts measured at 0.1% and 1% using the Mitoread AntiOx mtROS method.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400701
06LabNot a test of Palmitoyl tripeptide-38 aloneIn vitro (cells)Efficacy outcome
In human fibroblasts, the multi-active serum at 1% significantly increased oxygen consumption.
In plain wordsIn cells, the multi-active serum at 1% increased oxygen use.
Peptide
Palmitoyl tripeptide-38
Outcome
IncreaseOxygen consumption at 1%
Study
humann: not reported in source
senescent cultured fibroblasts
Outcome group
Mitochondrial function · Aging and longevity
Source sentences
Summary
The tested serum both at 0.1% and 1% induces a significant increase in 02 consumption, cellular ATP level and a reduction in extra-cellular lactate concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of the serum on the mitochondrial ROS (reactive oxygen species) production in human senescent cultured fibroblasts measured at 0.1% and 1% using the Mitoread AntiOx mtROS method.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400702
07LabNot a test of Palmitoyl tripeptide-38 aloneIn vitro (cells)Efficacy outcome
In human fibroblasts, the multi-active serum at 0.1% significantly increased cellular ATP.
In plain wordsIn cells, the multi-active serum at 0.1% increased ATP levels.
Peptide
Palmitoyl tripeptide-38
Outcome
IncreaseATP at 0.1%
Study
humann: not reported in source
senescent cultured fibroblasts
Outcome group
Mitochondrial function · Aging and longevity
Source sentences
Summary
The tested serum both at 0.1% and 1% induces a significant increase in 02 consumption, cellular ATP level and a reduction in extra-cellular lactate concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of the serum on the mitochondrial ROS (reactive oxygen species) production in human senescent cultured fibroblasts measured at 0.1% and 1% using the Mitoread AntiOx mtROS method.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400703
08LabNot a test of Palmitoyl tripeptide-38 aloneIn vitro (cells)Efficacy outcome
In human fibroblasts, the multi-active serum at 1% significantly increased cellular ATP.
In plain wordsIn cells, the multi-active serum at 1% increased ATP levels.
Peptide
Palmitoyl tripeptide-38
Outcome
IncreaseATP at 1%
Study
humann: not reported in source
senescent cultured fibroblasts
Outcome group
Mitochondrial function · Aging and longevity
Source sentences
Summary
The tested serum both at 0.1% and 1% induces a significant increase in 02 consumption, cellular ATP level and a reduction in extra-cellular lactate concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of the serum on the mitochondrial ROS (reactive oxygen species) production in human senescent cultured fibroblasts measured at 0.1% and 1% using the Mitoread AntiOx mtROS method.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400704
09LabNot a test of Palmitoyl tripeptide-38 aloneIn vitro (cells)Efficacy outcome
In human fibroblasts, the multi-active serum at 0.1% significantly reduced extracellular lactate.
In plain wordsIn cells, the multi-active serum at 0.1% reduced extracellular lactate.
Peptide
Palmitoyl tripeptide-38
Outcome
DecreaseExtracellular lactate at 0.1%
Study
humann: not reported in source
senescent cultured fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The tested serum both at 0.1% and 1% induces a significant increase in 02 consumption, cellular ATP level and a reduction in extra-cellular lactate concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of the serum on the mitochondrial ROS (reactive oxygen species) production in human senescent cultured fibroblasts measured at 0.1% and 1% using the Mitoread AntiOx mtROS method.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400705
10LabNot a test of Palmitoyl tripeptide-38 aloneIn vitro (cells)Efficacy outcome
In human fibroblasts, the multi-active serum at 1% significantly reduced extracellular lactate.
In plain wordsIn cells, the multi-active serum at 1% reduced extracellular lactate.
Peptide
Palmitoyl tripeptide-38
Outcome
DecreaseExtracellular lactate at 1%
Study
humann: not reported in source
senescent cultured fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The tested serum both at 0.1% and 1% induces a significant increase in 02 consumption, cellular ATP level and a reduction in extra-cellular lactate concentration.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of the serum on the mitochondrial ROS (reactive oxygen species) production in human senescent cultured fibroblasts measured at 0.1% and 1% using the Mitoread AntiOx mtROS method.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400706
11LabNot a test of Palmitoyl tripeptide-38 aloneIn vitro (cells)Efficacy outcome
In human fibroblasts, the multi-active serum significantly reduced mitochondrial ROS production.
In plain wordsIn cells, the multi-active serum reduced mitochondrial reactive oxygen species production.
Peptide
Palmitoyl tripeptide-38
Outcome
DecreaseMitochondrial ROS production
Study
humann: not reported in source
senescent cultured fibroblasts
Outcome group
Mitochondrial function · Aging and longevity
Source sentences
Summary
The product reduces also significantly the mitochondrial ROS production.
2 context sentences(design, population, supporting numbers)
Summary · context
We evaluated the effects of the serum on the mitochondrial ROS (reactive oxygen species) production in human senescent cultured fibroblasts measured at 0.1% and 1% using the Mitoread AntiOx mtROS method.
Summary · context
A new dermocosmetic product containing apple stem cell extract, urea, creatine and palmitoyl tripeptide-38 (Ureadin Fusion Serum Lift Antiarrugas, ISDIN S.A), has been recently developed to target different aspects involved in skin aging.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-2642400707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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