PepBank has 6 Dihexa studies with results. 3 of them gave Dihexa, with 15 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.
Searches 15 results and 17 papers. Newer studies from Europe PMC
Identifiers, parent molecule, targets and development stage, from curated data.
Dihexa is a peptide-derived peptidomimetic with an N-hexanoyl group, Tyr-Ile segment and aminohexanamide tail. PubChem defines its exact structure. FDA lists PNB-0408 and ATH-1001 as substance synonyms. Fosgonimeton has a different formula and InChIKey. No approved product matched the limited FDA and EMA name checks. Target, parent and clinical phase remain unresolved.
No molecular target is recorded for this peptide.
Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.
Sequence not disclosed
PubChem defines N-hexanoyl-Tyr-Ile with a 6-aminohexanamide tail. The name Dihexa does not mean a six-residue unmodified peptide. No canonical amino-acid sequence is assigned.
No sequence is listed, so nothing can be calculated.
No charge curve
No sequence is listed for this peptide.
No sequence is listed for this peptide.
No 3D structure
No experimental structure (PDB) and no UniProt entry for an AlphaFold model are listed for this peptide. Synthetic peptides often have neither. The sequence view above is the reference.
Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).
SMILES fromPubChem CID 129010512(opens in a new tab)
CCCCCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCCCCCC(=O)NPeople first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.
PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.
Counts are exact and come from studies that gave the peptide.
Studies by year
6 of 17 studies have results (35%), published 2015 to 2024. Top row: every study. Bottom row: studies with results about Dihexa, by class. The rows use different scales.
Studies17 in all, 1992 to 2026
Studies with results6 in all, 2015 to 2024
Retracted studies are left out. A study with results in two classes counts in both.
AI wrote and checked these results. AI can make mistakes, so check important results against the source.
Registered trials that test the peptide, with phase, status and dates. A dot marks trials with posted results.
0 trials match. Highest phase first. Data from ClinicalTrials.gov.
No trial matches these filters.
Studies on this peptide. Some have results. The others have none yet.
17 studies match. Retracted studies are left out.
Showing 10 of 17 studiesquery qry_9b02ac0e11594670719dfa63
6 studies
Not a test of Dihexa alone · 2018
Ho et al. 2018Neuroscience and biobehavioral reviewscited by 42
PMID 29733881PMC8916541DOI 10.1016/j.neubiorev.2018.05.005PUB-29733881
Animal study (in vivo) · mouse · 2021
Sun et al. 2021Brain sciencescited by 12
PMID 34827486PMC8615599DOI 10.3390/brainsci11111487PUB-34827486
Not a test of Dihexa alone · 2022
Pan et al. 2022Stem cell research & therapycited by 11
PMID 35410439PMC8996222DOI 10.1186/s13287-022-02831-1PUB-35410439
Animal study (in vivo) · zebrafish · 2015
Uribe et al. 2015Frontiers in cellular neurosciencecited by 10
PMID 25674052PMC4309183DOI 10.3389/fncel.2015.00003PUB-25674052
Not a test of Dihexa alone · 2021
Weiss et al. 2021Annals of medicine and surgery (2012)cited by 1
PMID 34703584PMC8524106DOI 10.1016/j.amsu.2021.102917PUB-34703584
Animal study (in vivo) · rat · 2024
Wells et al. 2024Journal of Huntington's diseasecited by 1
PMID 38489193DOI 10.3233/jhd-231507PUB-38489193
4 studies
Indexing hint: Animal study · 2013
McCoy et al. 2013The Journal of pharmacology and experimental therapeuticscited by 39
PMID 23055539PMC3533412DOI 10.1124/jpet.112.199497PUB-23055539
PubMed tag: Review · 2015
Wright et al. 2015Progress in neurobiologycited by 34
PMID 25455861DOI 10.1016/j.pneurobio.2014.11.004PUB-25455861
PubMed tag: Review · 2015
Wright et al. 2015Journal of Alzheimer's disease : JADcited by 30
PMID 25649658DOI 10.3233/jad-142814PUB-25649658
PubMed tag: Preprint · 2021
Pan et al. 2021Research Square
DOI 10.21203/rs.3.rs-1169294/v1PUB-97314626
These studies name Dihexa but give no result for it (for example, the results concern another peptide in the study).
PubMed tag: none · 2014
Nowotarska et al. 2014Molecules (Basel, Switzerland)cited by 55
PMID 24914896PMC6271777DOI 10.3390/molecules19067497PUB-24914896
Indexing hint: Animal study · 1992
Rider et al. 1992The American journal of physiologycited by 48
PMID 1514645DOI 10.1152/ajplung.1992.263.2.l201PUB-01514645
PubMed tag: none · 2016
Mathapati et al. 2016Current protocols in stem cell biologycited by 35
PMID 27532814DOI 10.1002/cpsc.13PUB-27532814
PubMed tag: none · 2007
Bapst et al. 2007Journal of receptor and signal transduction researchcited by 13
PMID 18097939DOI 10.1080/10799890701723528PUB-18097939
Indexing hint: Animal study · 2005
Kessel et al. 2005Photochemistry and photobiologycited by 10
PMID 15745423PMC2972548DOI 10.1562/2004-12-16-ra-403PUB-15745423
PubMed tag: none · 2014
Hu et al. 2014Biomicrofluidicscited by 2
PMID 25332729PMC4189399DOI 10.1063/1.4895570PUB-25332729
PubMed tag: review-article, Review · 2026
Rahman et al. 2026Journal of the American Academy of Orthopaedic Surgeons. Global research & reviewscited by 2
PMID 41490200PMC12753158DOI 10.5435/jaaosglobal-d-25-00236PUB-41490200
Page 1 of 1
Sun X · Brain sciences · 2021
Animal study (in vivo) · mouse · 13 results
Uribe PM · Frontiers in cellular neuroscience · 2015
Animal study (in vivo) · zebrafish · 8 results
Wells RG · Journal of Huntington's disease · 2024
Animal study (in vivo) · rat · 1 result
Pan T · Stem cell research & therapy · 2022
Not a test of Dihexa alone · 5 results
Weiss JB · Annals of medicine and surgery (2012) · 2021
Not a test of Dihexa alone · 5 results
Ho JK · Neuroscience and biobehavioral reviews · 2018
Not a test of Dihexa alone · 2 results
Approval and sport status, and the safety outcomes reported in study results. Laws and labels change, so check the regulator for the current status.
| Jurisdiction | Body | Status | As of | Source |
|---|---|---|---|---|
| US | FDA | No Dihexa or PNB-0408 active ingredient matched the openFDA Drugs@FDA search. This negative search has limited coverage. UNII registration does not establish approval. | 13 Oct 2026 | api.fda.gov (opens in a new tab) |
| EU | EMA | No matching active substance in the EMA central medicines data file. National authorisations are not covered. | 13 Oct 2026 | ema.europa.eu (opens in a new tab) |
| Sport | WADA | Status unknown USADA links this PDF as the 2026 List. | 2026 List | wada-ama.org (opens in a new tab) |
| Russia | Note | National medicine registration not established in this profile. | 13 Oct 2026 | Not recorded |
Reported effects from study results.
No safety results from studies in people
The doses that these studies used. They are not recommendations.
1 μMAnimal
PepBank is a research reference. Talk to a doctor before you use any peptide.
Data version, change history and code for this peptide.
curl -s https://Evidence summary for Dihexa: counts by class, key results with sources, notices, data version.
In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated
Top outcomes
The 4 outcome groups with the most study results, by evidence class.
Data version 308560. Bar length is the number of results, not the size of an effect.
Evidence matrix
Study results by outcome and evidence class. Arrows show how the measured outcome moved, not whether the change is good.
| Outcome group | Human | Animal | Lab | Computer model | Total |
|---|---|---|---|---|---|
| Inflammation markersNervous system and cognition | No results | Animal: 5 results from 1 study: 1 increase, 4 decrease. Strongest design: Animal study (in vivo) | No results | No results | 5 |
| NeuroprotectionNervous system and cognition | No results | Animal: 5 results from 3 studies: 3 increase, 2 no significant change. Strongest design: Animal study (in vivo) | No results | No results | 5 |
| Receptor activity and mechanismNervous system and cognition | No results | Animal: 3 results from 1 study: 3 increase. Strongest design: Animal study (in vivo) | No results | No results | 3 |
| Cognition and memoryNervous system and cognition | No results | Animal: 2 results from 1 study: 2 increase. Strongest design: Animal study (in vivo) | No results | No results | 2 |
4 outcome groups shown of 4 · 15 study results
Data version 308560. Shade grows with the number of results. Every cell shows the exact count.