Peptides / Brain and mood

Synthetic analog · 504.7 Da

Dihexa

Not approved

Dihexa, also listed as PNB-0408 and ATH-1001, is a lab-made, peptide-like compound studied for memory and brain protection. It is not approved, and all its study results come from animals, mostly on the nervous system. PepBank shows 15 results on Dihexa from animal and lab studies. No study in people has reported results yet. Data as of 2026-10-30.

Also known as ATH-1001, PNB-0408, PNB0408

Evidence level: Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.

Results in people

0% of 15 results

Results in animals

100% of 15 results

Results in lab cells

0% of 15 results

From computer models

0% of 15 results

Overview

Dihexa at a glance

What it is	Synthetic analog
Approval	Not approved for any use
In sport	Status unknown
Studies	6 studies with results. 3 of them gave Dihexa, with 15 results. 15 in animals
Clinical trials	None registered
Community use	Community cognitive use

The science

What is Dihexa?

Peptidomimetic identified as Dihexa, PNB-0408 and ATH-1001 in the FDA substance registry.

Study results in PepBank

Dihexa structure and chemistry

The key facts about the molecule. Long codes are in the closed section below.

Structure

Dihexa is a synthetic analog, with no ring, no changed amino acids.

Formula

C₂₇H₄₄N₄O₅

Molecular weight

504.7 g/mol

CAS number

1401708-83-5

Development

Highest phase: no known clinical development.

Identifiers

PubChem 129010512, UNII 9WYX65A5C2

SMILES and InChIKey

Three-letter sequence
N-hexanoyl-Tyr-Ile-(6-aminohexanamide)

InChIKey
XEUVNVNAVKZSPT-JTJYXVOQSA-N

SMILES
CCCCCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCCCCCC(=O)N

See charge, composition and 3D structure on the Scientific page

The evidence

What Dihexa studies show

Results grouped by what the studies measured. Each card shows where its results come from.

Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.

Brain and nerves

5 results · 5 animal

In mice, Dihexa increased nerve cells assessed by tissue staining. Brain sciences, 2021

Immune system and inflammation

5 results · 5 animal

In mice, Dihexa decreased astrocyte activation. Brain sciences, 2021

Memory and thinking

2 results · 2 animal

In mice, Dihexa restored spatial learning in a water maze test. Brain sciences, 2021

Key Dihexa studies

Studies in people come first, then studies in animals and in the lab.

Animals
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway
Sun et al. 2021 · Brain sciences · cited by 12
11 results
Animals
Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure
Uribe et al. 2015 · Frontiers in cellular neuroscience · cited by 10
3 results
Animals
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats
Wells et al. 2024 · Journal of Huntington's disease · cited by 1
1 result

All 6 Dihexa studies

Dihexa clinical trials

ClinicalTrials.gov lists no trial of Dihexa. A trial under another name may exist.

Status and safety

Is Dihexa approved?

FDA

United States

Not approved

No approved medicine contains it.

EMA

European Union

Not approved

No approved medicine contains it.

WADA

Sport

Not recorded

Status unknown.

No. Not approved for any use. The sources we use show no clinical development. They show no approval at the FDA, the EMA or elsewhere (as of 13 Oct 2026). Status unknown.

Laws and labels change, so check the regulator for the current status.

Dihexa side effects and safety

PepBank has no safety result from studies of Dihexa yet. That does not mean Dihexa is safe.

Doses studied (1 shown)

The doses that these studies used. They are not recommendations.

Dose as reported	Class	Species	Route	Duration	Design	Source
1 μM	Animal	Zebrafish	Not reported	Not reported	Study in live animals	Uribe 2015

From the community

How people use it

What people report online. It comes from forums and guides, not from studies.

Community-reported. Not tested in trials.

The source reports this use pattern. It does not establish safety or efficacy.

Reported routines and cautions

What people use it for

Community cognitive useS1

Reported regimens

Regimens that community sources report for Dihexa. Community-reported, not tested in trials.
Context	Route	Amount	How often	How long	Agreement	Sources
Community cognitive use	oral	5 to 10 mg per dose	once daily	4 to 8 weeks with cycling	Single aggregate wiki source. The source does not establish agreement between independently checked users.	S1

Community sources

S1Dihexa community protocols (opens in a new tab)www.peptideprotocolwiki.com

Gaps

Single-source report. Product identity, actual use and product purity were not independently tested.

Questions and more

Ask a question about Dihexa

The answer links to every study it uses.

What does the evidence say about Dihexa?Is Dihexa tested in people?Compare with Cerebrolysin Compare with Cortexin (cortical polypeptide complex)

Sources

Database: PepBank data for Dihexa (data version 308560)
Regulator: FDA status record
Regulator: EMA status record
Regulator: WADA status record
Community: community sources (forums and guides), as summarized in the PepBank community file

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Ask your AI about Dihexa

Curo is a peptide shop. PepBank and Curo have the same owner. See the Curo catalog (opens in a new tab).

Dihexa

Not approved

Also known as ATH-1001, PNB-0408, PNB0408

What it is

Synthetic analog

Approval

Not approved for any use

In sport

Status unknown

Studies

6 studies with results. 3 of them gave Dihexa, with 15 results.
15 in animals

Clinical trials

None registered

Community use

Community cognitive use

Dose as reported

Class

Species

Route

Duration

Design

Source

1 μM

Animal

Zebrafish

Not reported

Study in live animals

Uribe 2015

Context

Route

Amount

How often

How long

Agreement

Sources

Community cognitive use

oral

5 to 10 mg per dose

once daily

4 to 8 weeks with cycling

Single aggregate wiki source. The source does not establish agreement between independently checked users.

Dihexa

Dihexa at a glance

What is Dihexa?

Dihexa structure and chemistry