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Study · Not a test of the peptide alone · 2021

5 results

Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.

Weiss JB, Phillips CJ, Malin EW, Gorantla VS, Harding JW, Salgar SK

Annals of medicine and surgery (2012)8 Oct 2021Cited by 1 (Europe PMC)

PMID34703584 (opens in a new tab)PMCIDPMC8524106 (opens in a new tab)DOI10.1016/j.amsu.2021.102917 (opens in a new tab)PepBankPUB-34703584
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Dihexa was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Dihexa.

  1. 01AnimalNot a test of Dihexa aloneAnimal study (in vivo)Efficacy outcome

    In rats after nerve repair, sensory function approached normal by 8 weeks across all treatment groups combined, including Dihexa groups.

    In plain wordsIn rats after nerve repair, sensory function approached normal across all groups combined, including Dihexa groups.

    Peptide
    Dihexa
    Outcome
    IncreaseSensory function in all nerve boundaries
    Study

    Ratn: not reported in source

    Male Lewis rats with sciatic nerve transection and repair
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Sensory function grade
    2.7 grade
    all groups combined at 8 weeks

    Source sentences

    Summary
    The sensory function in all nerve boundaries (peroneal, tibial, sural) returned to nearly normal by 8 weeks (Grade 2.7 on a scale of Grade 0-3 [0 = No function; 3 = Normal function]) in all groups combined.
    3 context sentences
    Summary · context
    There were 10 experimental groups (n = 6-8 rats/group).
    Summary · context
    Bone marrow derived syngeneic MSCs (2 × 106; passage≤6), G-CSF (200-400 μg/kg b.wt.), Dihexa (2-4 mg/kg b.wt.) and/or Vehicle were administered to male Lewis rats locally via hydrogel at the site of nerve repair, systemically (i.v./i.p), and/or to gastrocnemius muscle.
    Summary · context
    The limb sensory and motor functions were assessed at 1-2 week intervals post nerve repair until the study endpoint (16 weeks).

    In this study, Dihexa was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dihexa.

  2. 02AnimalNot a test of Dihexa aloneAnimal study (in vivo)Efficacy outcome

    In rats after nerve repair, pooled peroneal nerve function returned at one week, with a grade of approximately 2.0.

    In plain wordsIn rats after nerve repair, pooled peroneal nerve function returned at one week across the study groups.

    Peptide
    Dihexa
    Outcome
    IncreasePeroneal nerve function recovery
    Study

    Ratn: not reported in source

    Male Lewis rats with sciatic nerve transection and repair
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Peroneal function grade
    ≈ 2 grade
    one week

    Source sentences

    Summary
    The peroneal nerve function recovered quickly with return of function at one week (∼2.0) while sural nerve function recovered rather slowly at four weeks (∼1.0).
    4 context sentences
    Summary · context
    The sensory function in all nerve boundaries (peroneal, tibial, sural) returned to nearly normal by 8 weeks (Grade 2.7 on a scale of Grade 0-3 [0 = No function; 3 = Normal function]) in all groups combined.
    Summary · context
    There were 10 experimental groups (n = 6-8 rats/group).
    Summary · context
    Bone marrow derived syngeneic MSCs (2 × 106; passage≤6), G-CSF (200-400 μg/kg b.wt.), Dihexa (2-4 mg/kg b.wt.) and/or Vehicle were administered to male Lewis rats locally via hydrogel at the site of nerve repair, systemically (i.v./i.p), and/or to gastrocnemius muscle.
    Summary · context
    The limb sensory and motor functions were assessed at 1-2 week intervals post nerve repair until the study endpoint (16 weeks).

    In this study, Dihexa was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dihexa.

  3. 03AnimalNot a test of Dihexa aloneAnimal study (in vivo)Efficacy outcome

    In rats after nerve repair, pooled sural nerve function returned at four weeks, with a grade of approximately 1.0.

    In plain wordsIn rats after nerve repair, pooled sural nerve function returned at four weeks across the study groups.

    Peptide
    Dihexa
    Outcome
    IncreaseSural nerve function recovery
    Study

    Ratn: not reported in source

    Male Lewis rats with sciatic nerve transection and repair
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Sural function grade
    ≈ 1 grade
    four weeks

    Source sentences

    Summary
    The peroneal nerve function recovered quickly with return of function at one week (∼2.0) while sural nerve function recovered rather slowly at four weeks (∼1.0).
    4 context sentences
    Summary · context
    The sensory function in all nerve boundaries (peroneal, tibial, sural) returned to nearly normal by 8 weeks (Grade 2.7 on a scale of Grade 0-3 [0 = No function; 3 = Normal function]) in all groups combined.
    Summary · context
    There were 10 experimental groups (n = 6-8 rats/group).
    Summary · context
    Bone marrow derived syngeneic MSCs (2 × 106; passage≤6), G-CSF (200-400 μg/kg b.wt.), Dihexa (2-4 mg/kg b.wt.) and/or Vehicle were administered to male Lewis rats locally via hydrogel at the site of nerve repair, systemically (i.v./i.p), and/or to gastrocnemius muscle.
    Summary · context
    The limb sensory and motor functions were assessed at 1-2 week intervals post nerve repair until the study endpoint (16 weeks).

    In this study, Dihexa was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dihexa.

  4. 04AnimalNot a test of Dihexa aloneAnimal study (in vivo)Efficacy outcome

    In rats after nerve repair, MSC plus Dihexa administration into gastrocnemius muscle significantly improved walking footprint grades at 8-16 weeks.

    In plain wordsIn rats after nerve repair, MSC plus Dihexa into calf muscle improved walking footprint grades.

    Peptide
    Dihexa
    Outcome
    IncreaseMotor function
    Study

    Ratn: not reported in source

    Male Lewis rats with sciatic nerve transection and repair
    Outcome group
    Exercise and physical function · Musculoskeletal

    Source sentences

    Summary
    Motor function at 8-16 weeks post-nerve repair as determined by walking foot print grades significantly (P < 0.05) improved with MSC + G-CSF or MSC + Dihexa administrations into gastrocnemius muscle and mitigated foot flexion contractures.
    3 context sentences
    Summary · context
    There were 10 experimental groups (n = 6-8 rats/group).
    Summary · context
    Bone marrow derived syngeneic MSCs (2 × 106; passage≤6), G-CSF (200-400 μg/kg b.wt.), Dihexa (2-4 mg/kg b.wt.) and/or Vehicle were administered to male Lewis rats locally via hydrogel at the site of nerve repair, systemically (i.v./i.p), and/or to gastrocnemius muscle.
    Summary · context
    The limb sensory and motor functions were assessed at 1-2 week intervals post nerve repair until the study endpoint (16 weeks).

    In this study, Dihexa was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dihexa.

  5. 05AnimalNot a test of Dihexa aloneAnimal study (in vivo)Efficacy outcome

    In rats after nerve repair, MSC plus Dihexa administration into gastrocnemius muscle mitigated foot flexion contractures.

    In plain wordsIn rats after nerve repair, MSC plus Dihexa into calf muscle reduced foot flexion contractures.

    Peptide
    Dihexa
    Outcome
    DecreaseFoot flexion contractures
    Study

    Ratn: not reported in source

    Male Lewis rats with sciatic nerve transection and repair
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Motor function at 8-16 weeks post-nerve repair as determined by walking foot print grades significantly (P < 0.05) improved with MSC + G-CSF or MSC + Dihexa administrations into gastrocnemius muscle and mitigated foot flexion contractures.
    3 context sentences
    Summary · context
    There were 10 experimental groups (n = 6-8 rats/group).
    Summary · context
    Bone marrow derived syngeneic MSCs (2 × 106; passage≤6), G-CSF (200-400 μg/kg b.wt.), Dihexa (2-4 mg/kg b.wt.) and/or Vehicle were administered to male Lewis rats locally via hydrogel at the site of nerve repair, systemically (i.v./i.p), and/or to gastrocnemius muscle.
    Summary · context
    The limb sensory and motor functions were assessed at 1-2 week intervals post nerve repair until the study endpoint (16 weeks).

    In this study, Dihexa was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dihexa.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:45 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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