Peptides / Immune and antimicrobial

Small molecule · 936.9 Da

Brilacidin

Brilacidin is an experimental non-peptide molecule that mimics the body's defense peptides, tested in phase 2 trials for infection and inflammation and not approved. Animal and lab studies tested it mostly on infections and on viruses, including SARS-CoV-2. PepBank shows 72 results on brilacidin from animal and lab studies. No study in people has reported results yet. Data as of 2026-10-30.

Also known as PMX-30063, PMX63

Small molecule, shown without its saltPubChem 25023695

Evidence level: Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists 5 trials.

Results in people

0% of 72 results

Results in animals

11% of 72 results

Results in lab cells

89% of 72 results

From computer models

0% of 72 results

Overview

Brilacidin at a glance

What it is	Small molecule
Approval	Regulatory status not recorded
In sport	Status unknown
Studies	17 studies with results. 15 of them gave brilacidin, with 72 results. 8 in animals64 in lab cells
Clinical trials	5 registered: 0 active or planned, 2 with posted results

The science

What is brilacidin?

A non-peptide defensin mimetic studied for antimicrobial and inflammatory indications.

Study results in PepBank

The history of brilacidin

2010October
A registered trial of brilacidin started (NCT01211470).
2014
The oldest paper on brilacidin in PepBank is from 2014.

Brilacidin structure and chemistry

The key facts about the molecule. Long codes are in the closed section below.

Structure

Brilacidin is a small molecule, not a peptide chain.

Formula

C₄₀H₅₀F₆N₁₄O₆

Molecular weight

936.9 g/mol

CAS number

1224095-98-0

Development

Innovation Pharmaceuticals. Highest phase: phase 2.

Identifiers

PubChem 25023695, ChEMBL CHEMBL2219413, UNII I1679X069H, DrugBank DB12997, KEGG D10414, IUPHAR 13807

SMILES and InChIKey

InChIKey
QPDYBCZNGUJZDK-DNQXCXABSA-N

SMILES
C1CNC[C@@H]1OC2=C(C=C(C=C2NC(=O)C3=CC(=NC=N3)C(=O)NC4=CC(=CC(=C4O[C@@H]5CCNC5)NC(=O)CCCCN=C(N)N)C(F)(F)F)C(F)(F)F)NC(=O)CCCCN=C(N)N

See charge, composition and 3D structure on the Scientific page

The evidence

What brilacidin studies show

Results grouped by what the studies measured. Each card shows where its results come from.

Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists 5 trials.

Infections

60 results · 7 animal · 53 lab

In rabbits with damaged corneal surfaces, brilacidin and vancomycin did not differ significantly in reducing MRSA. Journal of ocular pharmacology and therapeutics, 2016

Key brilacidin studies

Studies in people come first, then studies in animals and in the lab.

Animals
An Independent Evaluation of a Novel Peptide Mimetic, Brilacidin (PMX30063), for Ocular Anti-infective
Kowalski et al. 2016 · Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · cited by 69
12 results
Animals
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
Dos et al. 2023 · Nature communications · cited by 58
4 results
Animals
Brilacidin, a novel antifungal agent against <i>Cryptococcus neoformans</i>
Diehl et al. 2024 · mBio · cited by 14
5 results
Lab cells
A novel peptide mimetic, brilacidin, for combating multidrug-resistant Neisseria gonorrhoeae
Abdelsattar et al. 2025 · PloS one · cited by 10
5 results
Lab cells
Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16
Mensa et al. 2014 · Antimicrobial agents and chemotherapy · cited by 147
5 results

All 17 Brilacidin studies

Brilacidin clinical trials

ClinicalTrials.gov lists 5 trials of brilacidin. 0 are active or planned, and 2 have posted results. PepBank does not show trial results.

Solid bars are dates that happened. Hatched bars are planned dates. Data from ClinicalTrials.gov.

A Study to Evaluate the Efficacy and Safety of Brilacidin in Hospitalized Participants With COVID-19

Phase 2completed120 people

Study of the Effects of Brilacidin Oral Rinse on Radiation-induced Oral Mucositis in Patients With Head and Neck Cancer

Phase 2completed61 people

Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infections

Phase 2completed215 people

All 2 Brilacidin trials

Status and safety

Is brilacidin approved?

FDA

United States

Status unknown

Status unknown.

EMA

European Union

Status unknown

Status unknown.

WADA

Sport

Not recorded

Status unknown.

Regulatory status not recorded. Status unknown.

Laws and labels change, so check the regulator for the current status.

Brilacidin side effects and safety

PepBank has 4 safety results from studies of brilacidin. None of them come from studies in people, so they do not show what happens in people.

Safety results from studies (4)

In rabbits, brilacidin eye treatment caused minimal irritation. (Journal of ocular pharmacology and therapeutics, 2016)
In lab tests, brilacidin did not break down human red blood cells. (PloS one, 2025)
In cells from mice, brilacidin showed low toxicity. (Microbiology spectrum, 2026)
In cells from mammals, brilacidin showed high tolerability. (PloS one, 2025)

See every safety result on the Scientific page

Doses studied (3 shown)

The doses that these studies used. They are not recommendations.

Dose as reported	Class	Species	Route	Duration	Design	Source
0.5%	Animal	rabbit	topical	Not reported	Study in live animals	Kowalski 2016
0.6 to 12× MIC	Lab	Escherichia coli	Not reported	Not reported	Study on cells in a dish	Wilhelm 2025
≤3× MIC	Lab	Escherichia coli	Not reported	Not reported	Study on cells in a dish	Wilhelm 2025

Questions and more

Ask a question about brilacidin

The answer links to every study it uses.

What does the evidence say about brilacidin?Is brilacidin tested in people?Compare with Thymosin alpha-1 Compare with LL-37

Sources

Database: PepBank data for brilacidin (data version 308560)
Regulator: FDA status record
Regulator: EMA status record
Regulator: WADA status record
Trial registry: ClinicalTrials.gov

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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Brilacidin

Brilacidin at a glance

What is brilacidin?

The history of brilacidin

Brilacidin structure and chemistry

What brilacidin studies show

Infections

Key brilacidin studies

Brilacidin clinical trials

Is brilacidin approved?

Brilacidin side effects and safety

Ask a question about brilacidin

Related peptides

Sources

Brilacidin

Brilacidin at a glance

What is brilacidin?

The history of brilacidin

Brilacidin structure and chemistry

What brilacidin studies show

Infections

Key brilacidin studies

Brilacidin clinical trials

Is brilacidin approved?

Brilacidin side effects and safety

Ask a question about brilacidin

Related peptides

Sources