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Study · In vitro (cells) · escherichia coli · 2025

3 results

Antimicrobial Activity of Brilacidin against E. coli.

Wilhelm MJ, Sharifian Gh M, Mensa B, Howell GL, DeGrado WF, Dai HL

ACS infectious diseases3 Jun 2025

PMID40459286 (opens in a new tab)DOI10.1021/acsinfecdis.5c00023 (opens in a new tab)PepBankPUB-40459286
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In E. coli laboratory tests, brilacidin increased outer membrane permeability 2-fold.

    In plain wordsIn lab tests, brilacidin doubled E. coli outer membrane permeability.

    Peptide
    Brilacidin
    Outcome
    IncreaseOuter membrane permeability
    Study

    Escherichia colin: not reported in source

    Escherichia coli membranes
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    0.6 to 12× MICAs given in this study (Escherichia coli).

    Measurements

    Outer membrane permeability increase
    2 fold
    following exposure to 0.6 to 12× MIC BRI

    Source sentences

    Summary
    Following exposure to 0.6 to 12× MIC BRI, the permeability of the outer membrane was shown to increase 2-fold.
  2. 02LabIn vitro (cells)Mechanism

    In E. coli laboratory tests, near-MIC brilacidin increased inner membrane permeability.

    In plain wordsIn lab tests, near-MIC brilacidin increased E. coli inner membrane permeability.

    Peptide
    Brilacidin
    Outcome
    IncreaseInner membrane permeability near MIC
    Study

    Escherichia colin: not reported in source

    Escherichia coli membranes
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    ≤3× MICAs given in this study (Escherichia coli).

    Source sentences

    Summary
    Conversely, the permeability of the inner membrane was shown to exhibit more complicated behavior: Permeability increased for near-MIC doses (≤3× MIC) of BRI but was significantly reduced for higher concentrations.
  3. 03LabIn vitro (cells)Mechanism

    In E. coli laboratory tests, higher brilacidin concentrations significantly reduced inner membrane permeability.

    In plain wordsIn lab tests, higher brilacidin concentrations reduced E. coli inner membrane permeability.

    Peptide
    Brilacidin
    Outcome
    DecreaseInner membrane permeability at higher concentrations
    Study

    Escherichia colin: not reported in source

    Escherichia coli membranes
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, the permeability of the inner membrane was shown to exhibit more complicated behavior: Permeability increased for near-MIC doses (≤3× MIC) of BRI but was significantly reduced for higher concentrations.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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