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Study · In vitro (cells) · staphylococcus aureus · 2014

5 results

Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16.

Mensa B, Howell GL, Scott R, DeGrado WF

Antimicrobial agents and chemotherapy16 Jun 2014Cited by 147 (Europe PMC)

PMID24936592 (opens in a new tab)PMCIDPMC4135847 (opens in a new tab)DOI10.1128/aac.02955-14 (opens in a new tab)PepBankPUB-24936592
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In S. aureus, brilacidin caused membrane depolarization comparable to daptomycin.

    In plain wordsIn lab tests, brilacidin changed bacterial membrane voltage to a similar extent as daptomycin.

    Peptide
    Brilacidin
    Outcome
    IncreaseMembrane depolarization
    Study

    Staphylococcus aureusn: not reported in source

    Staphylococcus aureus
    Comparator
    Daptomycin
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study, we demonstrate that brilacidin causes membrane depolarization in the Gram-positive bacterium Staphylococcus aureus, to an extent comparable to that caused by the lipopeptidic drug daptomycin.
  2. 02LabIn vitro (cells)Mechanism

    In S. aureus, the transcriptional response to brilacidin correlated with daptomycin and LL37 responses and indicated cell wall and membrane dysfunction.

    In plain wordsIn lab tests, bacterial gene responses to brilacidin resembled responses to daptomycin and LL37 and indicated cell wall and membrane dysfunction.

    Peptide
    Brilacidin
    Outcome
    Not applicableTranscriptional response
    Study

    Staphylococcus aureusn: not reported in source

    Staphylococcus aureus
    Comparator
    Daptomycin and LL37
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Transcriptional profiling of Staphylococcus aureus by deep sequencing shows that the global response to brilacidin treatment is well correlated to those of treatment with daptomycin and the cationic antimicrobial peptide LL37 and mostly indicates abrogation of cell wall and membrane functions.
  3. 03LabIn vitro (cells)Mechanism

    In S. aureus, brilacidin upregulated chaperones, suggesting possible cytoplasmic protein misfolding stress.

    In plain wordsIn lab tests, brilacidin increased bacterial chaperones, which may indicate stress from misfolded proteins.

    Peptide
    Brilacidin
    Outcome
    IncreaseChaperone upregulation
    Study

    Staphylococcus aureusn: not reported in source

    Staphylococcus aureus
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, the upregulation of various chaperones and proteases by brilacidin and daptomycin indicates that cytoplasmic protein misfolding stress may be a contributor to the mechanism of action of these drugs.
  4. 04LabIn vitro (cells)Mechanism

    In S. aureus, brilacidin upregulated proteases, suggesting possible cytoplasmic protein misfolding stress.

    In plain wordsIn lab tests, brilacidin increased bacterial proteases, which may indicate stress from misfolded proteins.

    Peptide
    Brilacidin
    Outcome
    IncreaseProtease upregulation
    Study

    Staphylococcus aureusn: not reported in source

    Staphylococcus aureus
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, the upregulation of various chaperones and proteases by brilacidin and daptomycin indicates that cytoplasmic protein misfolding stress may be a contributor to the mechanism of action of these drugs.
  5. 05LabIn vitro (cells)Mechanism

    In S. aureus, GraSR, VraSR, and NsaSR mainly orchestrated stress responses associated with brilacidin treatment.

    In plain wordsIn lab tests, three bacterial regulatory systems mainly controlled stress responses associated with brilacidin treatment.

    Peptide
    Brilacidin
    Outcome
    Not applicableStress response regulation
    Study

    Staphylococcus aureusn: not reported in source

    Staphylococcus aureus
    Outcome group
    Receptor activity and mechanism · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These stress responses were orchestrated mainly by three two-component systems, GraSR, VraSR, and NsaSR, which have been implicated in virulence and drug resistance against other clinically available antibiotics.
    1 context sentence
    Summary · context
    Furthermore, the upregulation of various chaperones and proteases by brilacidin and daptomycin indicates that cytoplasmic protein misfolding stress may be a contributor to the mechanism of action of these drugs.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Versions 2 to 3

    27 Oct 2026, 16:32 UTC

    The same notice was added 2 times, first on 9 Oct 2026, 03:03 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:57 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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