Peptides / Skin and hair
Synthetic analog · 4 amino acids · 492.5 Da
Acetyl tetrapeptide-5
Not approved
Acetyl tetrapeptide-5 is a cosmetic peptide used in eye products marketed for puffiness, and it is not an approved drug. Lab research measured its activity on angiotensin-converting enzyme. PepBank shows 1 result on acetyl tetrapeptide-5 from animal and lab studies. No study in people has reported results yet. Data as of 2026-10-30.
Also known as acetyl tetrapeptide 5, Ac-beta-Ala-His-Ser-His-OH, Eyeseryl
4 amino acids, from first to lastXHSH
Evidence level: Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.
Results in people
0
0% of 1 results
Results in animals
0
0% of 1 results
Results in lab cells
1
100% of 1 results
From computer models
0
0% of 1 results
Overview
Acetyl tetrapeptide-5 at a glance
| What it is | Synthetic analog, 4 amino acids |
|---|---|
| Approval | Not approved for any use |
| In sport | Status unknown |
| Studies | 1 study with results. It gave acetyl tetrapeptide-5, with 1 result. 1 in lab cells |
| Clinical trials | None registered |
| Community use | Cosmetic eye creams for puffiness |
The science
What is acetyl tetrapeptide-5?
A cosmetic tetrapeptide used in eye products marketed for puffiness.
4
Amino acids in one chain
Acetyl tetrapeptide-5 structure and chemistry
The key facts about the molecule. Long codes are in the closed section below.
Sequence, 4 amino acidsFrom the first amino acid to the last
X1HSH
Darker means more water-repelling+ and − show charge in the bodyOutlined: changed amino acid
Structure
Acetyl tetrapeptide-5 is a synthetic analog of 4 amino acids, with no ring, 2 changed amino acids.
Formula
C20H28N8O7
Molecular weight
492.5 g/mol
CAS number
820959-17-9
Development
Lipotec / Lubrizol. Highest phase: unknown.
Identifiers
PubChem 11620163, UNII Y1DFQ308G8
Full sequence, SMILES and InChIKey
Three-letter sequenceAc-beta-Ala-L-His-L-Ser-L-His-OH
InChIKeyROTFCACGLKOUGI-JYJNAYRXSA-N
SMILESCC(=O)NCCC(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CN=CN2)C(=O)O
The evidence
What acetyl tetrapeptide-5 studies show
Results grouped by what the studies measured. Each card shows where its results come from.
Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.
Key acetyl tetrapeptide-5 studies
Studies in people come first, then studies in animals and in the lab.
- Lab cellsProtective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts1 resultWu et al. 2021 · Skin pharmacology and physiology · cited by 10
Acetyl tetrapeptide-5 clinical trials
ClinicalTrials.gov lists no trial of acetyl tetrapeptide-5. A trial under another name may exist.
Status and safety
Is acetyl tetrapeptide-5 approved?
FDA
United States
Not approvedNo approved medicine contains it.
EMA
European Union
Status unknownStatus unknown.
WADA
Sport
Not recordedStatus unknown.
No. Not approved for any use. The FDA and the other sources we use show no approval (as of 27 Oct 2026). Status unknown.
Laws and labels change, so check the regulator for the current status.
Acetyl tetrapeptide-5 side effects and safety
PepBank has no safety result from studies of acetyl tetrapeptide-5 yet. That does not mean acetyl tetrapeptide-5 is safe.
Doses studied (1 shown)
The doses that these studies used. They are not recommendations.
| Dose as reported | Class | Species | Route | Duration | Design | Source |
|---|---|---|---|---|---|---|
| 100 μg/mL | Lab | Not reported | Not reported | Not reported | Other study type | Wu 2021 |
From the community
How people use it
What people report online. It comes from forums and guides, not from studies.
Community-reported. Not tested in trials.
The ingredient guide describes cosmetic eye cream use for puffiness. This report does not establish clinical efficacy or safety.
Reported routines and cautions
What people use it for
- Cosmetic eye creams for puffinessS1
Reported regimens
| Context | Route | Amount | How often | How long | Agreement | Sources |
|---|---|---|---|---|---|---|
| Cosmetic eye creams for puffiness | topical | Not stated | Not stated | Not stated | Single non-vendor ingredient guide. The source remains affiliate-flagged. It describes manufacturer findings without independent confirmation. | S1 |
Community sources
- S1Acetyl Tetrapeptide-5 ingredient guideincidecoder.comcarries seller links, not linked
Gaps
No verified amount, frequency or duration is retained. The source does not establish independent outcomes or a safe regimen.
Questions and more
Ask a question about acetyl tetrapeptide-5
The answer links to every study it uses.
Sources
- Database: PepBank data for acetyl tetrapeptide-5 (data version 308560)
- Regulator: FDA status record
- Regulator: WADA status record
- Community: community sources (forums and guides), as summarized in the PepBank community file
AI wrote and checked these results. AI can make mistakes, so check important results against the source.
PepBank is a research reference. Talk to a doctor before you use any peptide.
Ask your AI about acetyl tetrapeptide-5
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