Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts.

Wu Y, Cao K, Zhang W, Zhang G, Zhou M

Skin pharmacology and physiology13 Apr 2021Cited by 10 (Europe PMC)

PMID33849044DOI10.1159/000514496PepBankPUB-33849044

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

2 results from studies that gave the peptide. No result from this study comes from people.

01LabOther designActivity measurement
In individual peptide assays, acetyl hexapeptide-3 had an optimal concentration of 400 μg/mL for catecholamine content activity.
In plain wordsIn lab tests, acetyl hexapeptide-3 showed optimal catecholamine content activity at 400 μg/mL.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
Not applicableOptimal concentration for catecholamine content activity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Skin and wound
Studied dose
400 μg/mLAs given in this study.
Measurements
Optimal concentration
400 μg/mL
acetyl hexapeptide-3 catecholamine content activity
Source sentences
Summary
and 400 μg/mL of acetyl hexapeptide-3 for the catecholamine content activity.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 5 functional cosmeceutical peptides were tested on their individual and mixed activities to detect a suitable anti-aging and protective formula from our experiments.
Report a problemFND-3384904401
02LabOther designActivity measurement
In an individual activity test, acetyl tetrapeptide-5 had an optimal concentration of 100 μg/mL for angiotensin-converting enzyme 1 activity.
In plain wordsIn lab tests, the optimal acetyl tetrapeptide-5 concentration for angiotensin-converting enzyme 1 activity was 100 μg/mL.
Peptide
Acetyl tetrapeptide-5
Outcome
Not applicableOptimal concentration for angiotensin-converting enzyme 1 activity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Pharmacology
Studied dose
100 μg/mLAs given in this study.
Measurements
Optimal concentration
100 μg/mL
angiotensin-converting enzyme 1 activity
Source sentences
Summary
100 μg/mL of acetyl tetrapeptide-5 for the angiotensin-converting enzyme 1 activity
Report a problemFND-3384904408

Studies that did not test the peptide alone12

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

03LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Activity measurement
In human skin fibroblasts, the mixture of carnosine, acetyl tetrapeptide-5, hexapeptide-11, and acetyl hexapeptide-3 reduced intracellular malondialdehyde.
In plain wordsIn cells, the four-peptide mixture reduced intracellular malondialdehyde.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseMalondialdehyde content
Study
humann: not reported in source
human skin fibroblasts with hydrogen peroxide-induced premature senescence
Outcome group
Aging markers · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 5 functional cosmeceutical peptides were tested on their individual and mixed activities to detect a suitable anti-aging and protective formula from our experiments.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3384904402
04LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Activity measurement
In human skin fibroblasts, the four-peptide mixture containing acetyl hexapeptide-3 reduced hydroxyl free radical content.
In plain wordsIn cells, the four-peptide mixture reduced hydroxyl free radical content.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
DecreaseHydroxyl free radical content
Study
humann: not reported in source
human skin fibroblasts with hydrogen peroxide-induced premature senescence
Outcome group
Aging markers · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 5 functional cosmeceutical peptides were tested on their individual and mixed activities to detect a suitable anti-aging and protective formula from our experiments.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3384904403
05LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Activity measurement
In human skin fibroblasts, the four-peptide mixture containing acetyl hexapeptide-3 increased HYP content.
In plain wordsIn cells, the four-peptide mixture increased hydroxyproline content.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseHydroxyproline content
Study
humann: not reported in source
human skin fibroblasts with hydrogen peroxide-induced premature senescence
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 5 functional cosmeceutical peptides were tested on their individual and mixed activities to detect a suitable anti-aging and protective formula from our experiments.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3384904404
06LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Activity measurement
In human skin fibroblasts, the four-peptide mixture containing acetyl hexapeptide-3 increased human elastin content.
In plain wordsIn cells, the four-peptide mixture increased elastin content.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseElastin content
Study
humann: not reported in source
human skin fibroblasts with hydrogen peroxide-induced premature senescence
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 5 functional cosmeceutical peptides were tested on their individual and mixed activities to detect a suitable anti-aging and protective formula from our experiments.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3384904405
07LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Activity measurement
In human skin fibroblasts, the four-peptide mixture containing acetyl hexapeptide-3 increased SOD activity.
In plain wordsIn cells, the four-peptide mixture increased superoxide dismutase activity.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseSuperoxide dismutase activity
Study
humann: not reported in source
human skin fibroblasts with hydrogen peroxide-induced premature senescence
Outcome group
Aging markers · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 5 functional cosmeceutical peptides were tested on their individual and mixed activities to detect a suitable anti-aging and protective formula from our experiments.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3384904406
08LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Activity measurement
In human skin fibroblasts, the four-peptide mixture containing acetyl hexapeptide-3 increased glutathione peroxidase activity.
In plain wordsIn cells, the four-peptide mixture increased glutathione peroxidase activity.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseGlutathione peroxidase activity
Study
humann: not reported in source
human skin fibroblasts with hydrogen peroxide-induced premature senescence
Outcome group
Aging markers · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, 5 functional cosmeceutical peptides were tested on their individual and mixed activities to detect a suitable anti-aging and protective formula from our experiments.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-3384904407
09LabNot a test of Acetyl tetrapeptide-5 aloneIn vitro (cells)Efficacy outcome
In human skin fibroblasts with hydrogen peroxide-induced premature senescence, the mixture containing acetyl tetrapeptide-5 significantly reduced intracellular malondialdehyde content.
In plain wordsIn cells, the mixture containing acetyl tetrapeptide-5 significantly reduced intracellular malondialdehyde content.
Peptide
Acetyl tetrapeptide-5
Outcome
DecreaseIntracellular malondialdehyde content
Study
humann: not reported in source
Human skin fibroblasts
Outcome group
Aging markers · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
According to the optimal concentration of these 5 cosmeceutical peptides, 6 formulations of peptide mixtures were designed and tested for their anti-aging activities and protective effects against hydrogen peroxide-induced premature senescence in human skin fibroblasts.
In this study, Acetyl tetrapeptide-5 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Acetyl tetrapeptide-5.
Report a problemFND-3384904409
10LabNot a test of Acetyl tetrapeptide-5 aloneIn vitro (cells)Efficacy outcome
In human skin fibroblasts with hydrogen peroxide-induced premature senescence, the mixture containing acetyl tetrapeptide-5 significantly reduced intracellular hydroxyl free radical content.
In plain wordsIn cells, the mixture containing acetyl tetrapeptide-5 significantly reduced intracellular hydroxyl free radical content.
Peptide
Acetyl tetrapeptide-5
Outcome
DecreaseIntracellular hydroxyl free radical content
Study
humann: not reported in source
Human skin fibroblasts
Outcome group
Aging markers · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
According to the optimal concentration of these 5 cosmeceutical peptides, 6 formulations of peptide mixtures were designed and tested for their anti-aging activities and protective effects against hydrogen peroxide-induced premature senescence in human skin fibroblasts.
In this study, Acetyl tetrapeptide-5 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Acetyl tetrapeptide-5.
Report a problemFND-3384904410
11LabNot a test of Acetyl tetrapeptide-5 aloneIn vitro (cells)Efficacy outcome
In human skin fibroblasts with hydrogen peroxide-induced premature senescence, the mixture containing acetyl tetrapeptide-5 increased hydroxyproline content.
In plain wordsIn cells, the mixture containing acetyl tetrapeptide-5 increased hydroxyproline content.
Peptide
Acetyl tetrapeptide-5
Outcome
IncreaseHydroxyproline content
Study
humann: not reported in source
Human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
According to the optimal concentration of these 5 cosmeceutical peptides, 6 formulations of peptide mixtures were designed and tested for their anti-aging activities and protective effects against hydrogen peroxide-induced premature senescence in human skin fibroblasts.
In this study, Acetyl tetrapeptide-5 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Acetyl tetrapeptide-5.
Report a problemFND-3384904411
12LabNot a test of Acetyl tetrapeptide-5 aloneIn vitro (cells)Efficacy outcome
In human skin fibroblasts with hydrogen peroxide-induced premature senescence, the mixture containing acetyl tetrapeptide-5 increased human elastin content.
In plain wordsIn cells, the mixture containing acetyl tetrapeptide-5 increased human elastin content.
Peptide
Acetyl tetrapeptide-5
Outcome
IncreaseHuman elastin content
Study
humann: not reported in source
Human skin fibroblasts
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
According to the optimal concentration of these 5 cosmeceutical peptides, 6 formulations of peptide mixtures were designed and tested for their anti-aging activities and protective effects against hydrogen peroxide-induced premature senescence in human skin fibroblasts.
In this study, Acetyl tetrapeptide-5 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Acetyl tetrapeptide-5.
Report a problemFND-3384904412
13LabNot a test of Acetyl tetrapeptide-5 aloneIn vitro (cells)Activity measurement
In human skin fibroblasts with hydrogen peroxide-induced premature senescence, the mixture containing acetyl tetrapeptide-5 increased superoxide dismutase enzymatic activity.
In plain wordsIn cells, the mixture containing acetyl tetrapeptide-5 increased superoxide dismutase activity.
Peptide
Acetyl tetrapeptide-5
Outcome
IncreaseSuperoxide dismutase enzymatic activity
Study
humann: not reported in source
Human skin fibroblasts
Outcome group
Aging markers · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
According to the optimal concentration of these 5 cosmeceutical peptides, 6 formulations of peptide mixtures were designed and tested for their anti-aging activities and protective effects against hydrogen peroxide-induced premature senescence in human skin fibroblasts.
In this study, Acetyl tetrapeptide-5 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Acetyl tetrapeptide-5.
Report a problemFND-3384904413
14LabNot a test of Acetyl tetrapeptide-5 aloneIn vitro (cells)Activity measurement
In human skin fibroblasts with hydrogen peroxide-induced premature senescence, the mixture containing acetyl tetrapeptide-5 increased glutathione peroxidase enzymatic activity.
In plain wordsIn cells, the mixture containing acetyl tetrapeptide-5 increased glutathione peroxidase activity.
Peptide
Acetyl tetrapeptide-5
Outcome
IncreaseGlutathione peroxidase enzymatic activity
Study
humann: not reported in source
Human skin fibroblasts
Outcome group
Aging markers · Skin and wound
Source sentences
Summary
One of the cosmeceutical peptide mixtures (carnosine + acetyl tetrapeptide-5 + hexapeptide-11 + acetyl hexapeptide-3) significantly reduced the intracellular malondialdehyde and hydroxyl free radical contents and increased the HYP and human elastin contents as well as the enzymatic activities of SOD…
1 context sentence(design, population, supporting numbers)
Summary · context
According to the optimal concentration of these 5 cosmeceutical peptides, 6 formulations of peptide mixtures were designed and tested for their anti-aging activities and protective effects against hydrogen peroxide-induced premature senescence in human skin fibroblasts.
In this study, Acetyl tetrapeptide-5 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Acetyl tetrapeptide-5.
Report a problemFND-3384904414

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:32 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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