PubMed tag: none · 2012
4 results
GPR54 peptide agonists stimulate insulin secretion from murine, porcine and human islets.
Bowe et al. 2012Isletscited by 42
PMID 22192948DOI 10.4161/isl.18261PUB-22192948
Rights unknown4 results
Trial · Interventional
CompletedPhase 3Registry dataKP-10 and Insulin Secretion in Men
NCTNCT03771326 (opens ClinicalTrials.gov in a new tab)Other idKisspeptin12
Overview
- Status
- Completed
- Phase
- Phase 3
- Enrollment
- 14 participants (actual)
- Sponsor
- Quaid-e-Azam University · Other
- Design
- Randomized · Open label (no masking)
- Countries
- Not stated
- Start
- 29 Oct 2013
- Primary completion
- 4 Nov 2013
- Completion
- 10 Jan 2014
- First posted
- 11 Dec 2018
- Last update posted
- 12 Dec 2018
- Conditions
- Kisspeptin Action on Insulin in Healthy Normal Men · Kisspeptin Action on Insulin in Obese Diabetic Men
Timeline
1 trial · 1 completed
- Completed
- Ongoing
- Not yet recruiting
- Stopped
- Estimated dates (est.)
- Results posted
201320142015
- Ph 3
Registry summary
Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.
Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear. The present study was designed to investigate the role of KP-10 on insulin secretion in adult healthy and obese men with insulin resistance. The aim of selection of obese persons for the present study was to investigate the effect of acute KP-10 administration in a metabolically challenged condition where the pancreatic beta cells are already highly activated. The long-term objective of this study was to understand the physiological role of kisspeptin signalling in the regulation of insulin secretion in human health and disease.
Interventions
- Kisspeptin-10Biological
Arms2
Experimental
obese men
To the 7 obese men, kisspeptin-10 was intravenously administered (0.5µg/kg BW, prepared under sterile conditions), as a bolus in a volume of 1ml. Blood samples from all the individuals were collected for 30 minutes pre and 120 minutes post-KP-10 administration, at 30 minutes interval. The obtained blood was centrifuged and the plasma insulin was measured by ELISA.
Experimental
Normal men
To the 7 normal BMI mean, kisspeptin-10 was intravenously administered (0.5µg/kg BW, prepared under sterile conditions), as a bolus in a volume of 1ml. Blood samples from all the individuals were collected for 30 minutes pre and 120 minutes post-KP-10 administration, at 30 minutes interval. The obtained blood was centrifuged and the plasma insulin was measured by ELISA.
Primary outcomes1
Outcomes the sponsor listed as primary.
Changes in the response of insulin secretion to acute exogenous kisspeptin administration
Time frame · Each participant was studied up to 4 hours. Blood samples from each individual was collected for 30 minutes pre and 120 minutes post KP-10 administration, at 30 minutes interval.
Registry description
The blood samples were obtained and analysed for insulin by Enzyme Linked Immunosorbent Assay to know the differential response of insulin secretion to exogenous kisspeptin-10 administration in healthy and obese men.
Posted results
Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.
No results are posted for this trial.
Completed trials do not always post results.
Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works
Studies2
Studies that cite this trial.
Studies with results
2 studies on this page
PubMed tag: none · 2011
2 results
Study on the effect of peripheral kisspeptin administration on basal and glucose-induced insulin secretion under fed and fasting conditions in the adult male rhesus monkey (Macaca mulatta).
Wahab et al. 2011Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolismecited by 33
PMID 21136344DOI 10.1055/s-0030-1268458PUB-21136344
Full text at the publisher2 results
Eligibility
Who could join, as posted.
- Sex
- Male
- Age
- from 20 Years up to 45 Years
- Healthy volunteers
- Accepted
Inclusion and exclusion criteria, as posted
Inclusion Criteria:
* Normal BMI
* Normal renal function
* Normal liver function
* Normal blood count
Exclusion Criteria:
* Disease history
* Diabetes
* Other trauma
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