In adult male rhesus monkeys, kisspeptin‑10 had no effect on basal plasma insulin in fed or fasting conditions compared with pretreatment or vehicle.
In plain wordsIn monkeys, kisspeptin‑10 did not change resting insulin levels, fed or fasting, compared with before treatment or with vehicle.
- Peptide
- Kisspeptin-10
- Outcome
- No significant changeBasal plasma insulin, fed and fasting
- Study
rhesus monkey (Macaca mulatta)n = 4
Adult male rhesus monkeys, fed and fasting- Comparator
- Vehicle and pretreatment
- Outcome group
- Glycemic control · Metabolic and weight
- Studied dose
- 50 μg · intravenous bolusAs given in this study (rhesus monkey (Macaca mulatta)).
Source sentences
KP10 administration had no effect on the basal insulin levels in both fed and fasting as compared to pretreatment or vehicle treatment levels, while it significantly heightened glucose stimulated insulin levels (p<0.05) in both fed and fasted monkeys.
1 context sentence(design, population, supporting numbers)
This study was designed to examine the effect of peripheral KP administration on basal and glucose-induced plasma insulin (an important pancreatic hormone) secretion under fed and fasting conditions in the adult male rhesus monkey.