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Study · Ex vivo tissue · mouse and pig · 2012

4 results

GPR54 peptide agonists stimulate insulin secretion from murine, porcine and human islets.

Bowe JE, Foot VL, Amiel SA, Huang GC, Lamb MW, Lakey J, Jones PM, Persaud SJ

Islets23 Dec 2011Cited by 42 (Europe PMC)

PMID22192948 (opens in a new tab)DOI10.4161/isl.18261 (opens in a new tab)PepBankPUB-22192948
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In isolated human islets perifused with 20 mM glucose, kisspeptin‑10 caused rapid, reversible potentiation of glucose-stimulated insulin secretion.

    In plain wordsIn lab tests on human islets, kisspeptin‑10 quickly and reversibly boosted insulin release triggered by glucose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGlucose-stimulated insulin secretion in human islets
    Study

    humann: not reported in source

    Perifused isolated human islets, 20 mM glucose
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both peptides stimulated rapid, reversible potentiation of glucose-stimulated insulin secretion from islets of all species tested.
    1 context sentence
    Summary · context
    Insulin secretion was measured by radioimmunoassay following perifusion of human, pig, rat and mouse isolated islets with kisspeptin-10 or kisspeptin-13 in the presence of 20 mM glucose.
  2. 02LabEx vivo tissueEfficacy outcome

    In isolated pig islets perifused with 20 mM glucose, kisspeptin‑10 caused rapid, reversible potentiation of glucose-stimulated insulin secretion.

    In plain wordsIn lab tests on pig islets, kisspeptin‑10 quickly and reversibly boosted insulin release triggered by glucose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGlucose-stimulated insulin secretion in pig islets
    Study

    pign: not reported in source

    Perifused isolated pig islets, 20 mM glucose
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both peptides stimulated rapid, reversible potentiation of glucose-stimulated insulin secretion from islets of all species tested.
    1 context sentence
    Summary · context
    Insulin secretion was measured by radioimmunoassay following perifusion of human, pig, rat and mouse isolated islets with kisspeptin-10 or kisspeptin-13 in the presence of 20 mM glucose.
  3. 03LabEx vivo tissueEfficacy outcome

    In isolated rat islets perifused with 20 mM glucose, kisspeptin‑10 caused rapid, reversible potentiation of glucose-stimulated insulin secretion.

    In plain wordsIn lab tests on rat islets, kisspeptin‑10 quickly and reversibly boosted insulin release triggered by glucose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGlucose-stimulated insulin secretion in rat islets
    Study

    ratn: not reported in source

    Perifused isolated rat islets, 20 mM glucose
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both peptides stimulated rapid, reversible potentiation of glucose-stimulated insulin secretion from islets of all species tested.
    1 context sentence
    Summary · context
    Insulin secretion was measured by radioimmunoassay following perifusion of human, pig, rat and mouse isolated islets with kisspeptin-10 or kisspeptin-13 in the presence of 20 mM glucose.
  4. 04LabEx vivo tissueEfficacy outcome

    In isolated mouse islets perifused with 20 mM glucose, kisspeptin‑10 caused rapid, reversible potentiation of glucose-stimulated insulin secretion.

    In plain wordsIn lab tests on mouse islets, kisspeptin‑10 quickly and reversibly boosted insulin release triggered by glucose.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGlucose-stimulated insulin secretion in mouse islets
    Study

    mousen: not reported in source

    Perifused isolated mouse islets, 20 mM glucose
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both peptides stimulated rapid, reversible potentiation of glucose-stimulated insulin secretion from islets of all species tested.
    1 context sentence
    Summary · context
    Insulin secretion was measured by radioimmunoassay following perifusion of human, pig, rat and mouse isolated islets with kisspeptin-10 or kisspeptin-13 in the presence of 20 mM glucose.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 3NCT03771326

KP-10 and Insulin Secretion in Men

Quaid-e-Azam Universityn = 1429 Oct 2013 to 10 Jan 2014

Kisspeptin Action on Insulin in Healthy Normal Men · Kisspeptin Action on Insulin in Obese Diabetic Men

Trial pageClinicalTrials.govUpdated 12 Dec 2018

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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