Trial · Interventional
CompletedPhase 3Registry dataPakistan
1 trial · 1 completed
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.
NCT0328651726 Jun 2014 to 5 Mar 2015
Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.
The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration across the pubertal stages and adult group through measuring plasma LH (luteinizing hormone) and testosterone concentrations.
Experimental
Tanner Stage I
A 1ml blood sample was obtained for 30 minutes pre and 120 minutes post-kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany) injection periods at 30 min intervals (-30, 0, 30, 60, 90, 120). The dose was 9.5 µg/BW.
Experimental
Tanner Stage II
A 1ml blood sample was obtained for 30 minutes pre and 120 minutes post-kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany) injection periods at 30 min intervals (-30, 0, 30, 60, 90, 120). The dose was 11.50 µg/BW.
Experimental
Tanner Stage III
A 1ml blood sample was obtained for 30 minutes pre and 120 minutes post-kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany) injection periods at 30 min intervals (-30, 0, 30, 60, 90, 120). The dose was 12.67 µg/BW.
Experimental
Tanner Stage IV
A 1ml blood sample was obtained for 30 minutes pre and 120 minutes post-kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany) injection periods at 30 min intervals (-30, 0, 30, 60, 90, 120). The dose was 15.11 µg/BW.
Experimental
Tanner stage V
A 1ml blood sample was obtained for 30 minutes pre and 120 minutes post-kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany) injection periods at 30 min intervals (-30, 0, 30, 60, 90, 120). The dose was 20.5 µg/BW.
Experimental
Adult Group
A 1ml blood sample was obtained for 30 minutes pre and 120 minutes post-kisspeptin-10 (metastin 45-54, Calbiochem, Darmstadt, Germany) injection periods at 30 min intervals (-30, 0, 30, 60, 90, 120). The dose was 1 µg/kg.
Outcomes the sponsor listed as primary.
To investigate the sensitivity of KISS1R by determining the responsiveness of GnRH neuron to kisspeptin administration across the pubertal stages and adult group through measuring plasma luteinizing hormone and testosterone concentrations
Time frame · A time frame for each individual was 3 hours. Kisspeptin-10 was injected intravenously and the blood samples were collected at 30 minutes intervals for 30 minutes pre and 2 hours post kisspeptin-10 injection through cannula.
Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.
No results are posted for this trial.
Completed trials do not always post results.
Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works
Studies that cite this trial.
4 studies on this page
PubMed tag: none · 2018
Nabi et al. 2018International journal of endocrinologycited by 7
PMID 30046307PMC6038494DOI 10.1155/2018/1475967PUB-30046307
PubMed tag: none · 2011
Jayasena et al. 2011The Journal of clinical endocrinology and metabolismcited by 105
PMID 21976724PMC3232613DOI 10.1210/jc.2011-1408PUB-21976724
Indexing hint: Randomized controlled trial · 2009
Jayasena et al. 2009The Journal of clinical endocrinology and metabolismcited by 149
PMID 19820030DOI 10.1210/jc.2009-0406PUB-19820030
Indexing hint: In vitro study · 2007
Mead et al. 2007Endocrinologycited by 96
PMID 17023533DOI 10.1210/en.2006-0818PUB-17023533
Who could join, as posted.
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