Changes in the Responsiveness of the Hypothalamic-Pituitary-Gonadal Axis to Kisspeptin-10 Administration during Pubertal Transition in Boys.

Nabi G, Ullah H, Khan S, Wahab F, Duan P, Ullah R, Yao L, Shahab M

International journal of endocrinology26 Jun 2018Cited by 7 (Europe PMC)

PMID30046307PMCIDPMC6038494DOI10.1155/2018/1475967PepBankPUB-30046307

Summary

In human, no studies are available regarding changes in kisspeptin1 receptor (KISS1R) sensitivity during pubertal transition. In this study, healthy boys were classified into 5 Tanner stages of puberty (n = 5/stage). Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n = 5) as an IV bolus for comparison. Serial blood samples were collected for 30 min pre- and 120 min post-kisspeptin injection periods at 30 min interval for measuring plasma LH and testosterone levels. There was insignificant effect of kisspeptin on LH and testosterone levels in boys of Tanner stages I-III. At Tanner stage IV, the effect of kisspeptin on plasma LH was insignificant. However, a paired t-test on a log-transformed data showed a significant (P < 0.05) increase in mean peak post-kisspeptin testosterone level. In Tanner stage V, a significant (P < 0.05) increase was observed in mean post-kisspeptin peak LH level as compared to the mean basal LH value. Post-kisspeptin plasma testosterone levels were also significantly (P < 0.05) increased as compared to the pre-kisspeptin level in Tanner stage V. Our data suggest that sensitivity of KISS1R on GnRH neurons with reference to LH stimulation in boys develops during the later part of puberty reaching to adult level at Tanner stage V. This trial is registered with WHO International Clinical Trial Registration ID NCT03286517.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In healthy boys at Tanner stage IV, the effect of intravenous kisspeptin‑10 on plasma LH was not significant.
In plain wordsIn boys at puberty stage IV, kisspeptin‑10 did not significantly change LH levels.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma LH response, Tanner stage IV
Study
n = 5
Comparator
Pre-kisspeptin baseline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous bolusAs given in this study (human).
Source sentences
Summary
At Tanner stage IV, the effect of kisspeptin on plasma LH was insignificant.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, healthy boys were classified into 5 Tanner stages of puberty (n = 5/stage).
Summary · context
Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n = 5) as an IV bolus for comparison.
Show in the study text Report a problemFND-3004630703
02HumanNon-randomized trialEfficacy outcome
In healthy boys at Tanner stage IV, mean peak testosterone after intravenous kisspeptin‑10 was significantly increased (P < 0.05).
In plain wordsIn boys at puberty stage IV, kisspeptin‑10 raised peak testosterone levels.
Peptide
Kisspeptin-10
Outcome
IncreasePeak post-kisspeptin testosterone, Tanner stage IV
Study
n = 5
Comparator
Pre-kisspeptin baseline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous bolusAs given in this study (human).
Source sentences
Summary
However, a paired t-test on a log-transformed data showed a significant (P < 0.05) increase in mean peak post-kisspeptin testosterone level.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, healthy boys were classified into 5 Tanner stages of puberty (n = 5/stage).
Summary · context
Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n = 5) as an IV bolus for comparison.
Show in the study text Report a problemFND-3004630704
03HumanNon-randomized trialEfficacy outcome
In healthy boys at Tanner stage V, mean peak LH after intravenous kisspeptin‑10 was significantly higher than the mean basal LH value (P < 0.05).
In plain wordsIn boys at puberty stage V, kisspeptin‑10 raised LH levels above their starting values.
Peptide
Kisspeptin-10
Outcome
IncreasePeak post-kisspeptin LH, Tanner stage V
Study
n = 5
Comparator
Basal LH value
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous bolusAs given in this study (human).
Source sentences
Summary
In Tanner stage V, a significant (P < 0.05) increase was observed in mean post-kisspeptin peak LH level as compared to the mean basal LH value.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, healthy boys were classified into 5 Tanner stages of puberty (n = 5/stage).
Summary · context
Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n = 5) as an IV bolus for comparison.
Show in the study text Report a problemFND-3004630705
04HumanNon-randomized trialEfficacy outcome
In healthy boys at Tanner stage V, plasma testosterone was significantly increased after intravenous kisspeptin‑10 compared with the pre-kisspeptin level (P < 0.05).
In plain wordsIn boys at puberty stage V, kisspeptin‑10 raised testosterone levels above their starting values.
Peptide
Kisspeptin-10
Outcome
IncreasePost-kisspeptin testosterone, Tanner stage V
Study
n = 5
Comparator
Pre-kisspeptin baseline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous bolusAs given in this study (human).
Source sentences
Summary
Post-kisspeptin plasma testosterone levels were also significantly (P < 0.05) increased as compared to the pre-kisspeptin level in Tanner stage V.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, healthy boys were classified into 5 Tanner stages of puberty (n = 5/stage).
Summary · context
Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n = 5) as an IV bolus for comparison.
Show in the study text Report a problemFND-3004630706
05HumanNon-randomized trialEfficacy outcome
In healthy boys at Tanner stages I-III, intravenous kisspeptin‑10 had no significant effect on plasma LH.
In plain wordsIn young boys at early puberty stages, kisspeptin‑10 did not change LH levels.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma LH response, Tanner stages I-III
Study
n: not reported in source
Comparator
Pre-kisspeptin baseline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous bolusAs given in this study (human).
Source sentences
Summary
There was insignificant effect of kisspeptin on LH and testosterone levels in boys of Tanner stages I-III.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, healthy boys were classified into 5 Tanner stages of puberty (n = 5/stage).
Summary · context
Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n = 5) as an IV bolus for comparison.
Show in the study text Report a problemFND-3004630701
06HumanNon-randomized trialEfficacy outcome
In healthy boys at Tanner stages I-III, intravenous kisspeptin‑10 had no significant effect on plasma testosterone.
In plain wordsIn young boys at early puberty stages, kisspeptin‑10 did not change testosterone levels.
Peptide
Kisspeptin-10
Outcome
No significant changePlasma testosterone response, Tanner stages I-III
Study
n: not reported in source
Comparator
Pre-kisspeptin baseline
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous bolusAs given in this study (human).
Source sentences
Summary
There was insignificant effect of kisspeptin on LH and testosterone levels in boys of Tanner stages I-III.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study, healthy boys were classified into 5 Tanner stages of puberty (n = 5/stage).
Summary · context
Human kisspeptin-10 was administered to boys at each Tanner stage and to adult men (n = 5) as an IV bolus for comparison.
Show in the study text Report a problemFND-3004630702

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 3NCT03286517

Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.

Ghulam Nabin = 3026 Jun 2014 to 5 Mar 2015

Reproductive Physiological Phenomena

Trial page ClinicalTrials.govUpdated 18 Sept 2017

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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