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Study · Ex vivo tissue · 2007

8 results

Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels.

Mead EJ, Maguire JJ, Kuc RE, Davenport AP

Endocrinology5 Oct 2006Cited by 96 (Europe PMC)

PMID17023533 (opens in a new tab)DOI10.1210/en.2006-0818 (opens in a new tab)PepBankPUB-17023533
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In isolated human coronary artery rings, KP-10 acted as a vasoconstrictor (pEC50 7.89).

    In plain wordsIn lab tests on human artery rings, KP-10 made the vessel narrow.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseVasoconstriction of coronary artery rings
    Study

    humann: not reported in source

    Isolated human coronary artery rings
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    pEC50
    7.89 -log M
    coronary artery
    Maximal response
    33.7 NA
    coronary artery

    Source sentences

    Summary
    KP-10, KP-13, and KP-54 acted as vasoconstrictors with comparable potency and efficacy in isolated rings of coronary artery (negative logarithm of the EC(50) and maximal response, respectively, as follows: KP-10, 7.89 +/- 0.24 and 33.7 +/- 17.0; KP-13, 8.66 +/- 0.88 and 35.1 +/- 7.9; KP-54, 8.86 +/-…
  2. 02LabEx vivo tissueActivity measurement

    In isolated human umbilical vein rings, KP-10 acted as a vasoconstrictor (pEC50 8.44).

    In plain wordsIn lab tests on human vein rings, KP-10 made the vessel narrow.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseVasoconstriction of umbilical vein rings
    Study

    humann: not reported in source

    Isolated human umbilical vein rings
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    pEC50
    8.44 -log M
    umbilical vein
    Maximal response
    24.3 NA
    umbilical vein

    Source sentences

    Summary
    and umbilical vein (negative logarithm of the EC(50) and maximal response, respectively, as follows: KP-10, 8.44 +/- 022 and 24.3 +/- 3.7; KP-13, 8.43 +/- 0.88 and 28.4 +/- 8.6; KP-54, 8.93 +/- 0.39 and 36.9 +/- 5.2).
  3. 03LabEx vivo tissueEfficacy outcome

    In isolated human coronary artery rings, kisspeptin‑54 acted as a vasoconstrictor (negative logarithm of the EC50 8.86, maximal response 25.7).

    In plain wordsIn lab tests on human artery rings, kisspeptin‑54 made the vessel tissue contract.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseVasoconstriction of isolated coronary artery rings
    Study

    humann: not reported in source

    isolated rings of human coronary artery
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    pEC50
    8.86 negative log EC50
    KP-54, coronary artery
    Maximal response
    25.7 NR
    KP-54, coronary artery

    Source sentences

    Summary
    KP-10, KP-13, and KP-54 acted as vasoconstrictors with comparable potency and efficacy in isolated rings of coronary artery (negative logarithm of the EC(50) and maximal response, respectively, as follows: KP-10, 7.89 +/- 0.24 and 33.7 +/- 17.0; KP-13, 8.66 +/- 0.88 and 35.1 +/- 7.9; KP-54, 8.86 +/-…
  4. 04LabEx vivo tissueEfficacy outcome

    In isolated human umbilical vein rings, kisspeptin‑54 acted as a vasoconstrictor (negative logarithm of the EC50 8.93, maximal response 36.9).

    In plain wordsIn lab tests on human vein rings, kisspeptin‑54 made the vessel tissue contract.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseVasoconstriction of isolated umbilical vein rings
    Study

    humann: not reported in source

    isolated rings of human umbilical vein
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Dose not stated

    Measurements

    pEC50
    8.93 negative log EC50
    KP-54, umbilical vein
    Maximal response
    36.9 NR
    KP-54, umbilical vein

    Source sentences

    Summary
    and umbilical vein (negative logarithm of the EC(50) and maximal response, respectively, as follows: KP-10, 8.44 +/- 022 and 24.3 +/- 3.7; KP-13, 8.43 +/- 0.88 and 28.4 +/- 8.6; KP-54, 8.93 +/- 0.39 and 36.9 +/- 5.2)
    1 context sentence
    Summary · context
    KP-10, KP-13, and KP-54 acted as vasoconstrictors with comparable potency and efficacy

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 05LabEndogenous levelEx vivo tissueOther

    RIA detected 13.04 fmol/g of the body's own kisspeptin in human coronary artery tissue.

    In plain wordsIn human artery tissue, lab tests found the body's own kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin content in human coronary artery
    Study

    humann: not reported in source

    Human coronary artery tissue
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Measurements

    Kisspeptin content
    13.04 fmol/g
    coronary artery

    Source sentences

    Summary
    RIA detected 13.04 +/- 2.94 and 20.50 +/- 5.00 fmol/g KP in human coronary artery and aorta, respectively

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 06LabEndogenous levelEx vivo tissueOther

    RIA detected 20.50 fmol/g of the body's own kisspeptin in human aorta tissue.

    In plain wordsIn human aorta tissue, lab tests found the body's own kisspeptin.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin content in human aorta
    Study

    humann: not reported in source

    Human aorta tissue
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Measurements

    Kisspeptin content
    20.5 fmol/g
    aorta

    Source sentences

    Summary
    RIA detected 13.04 +/- 2.94 and 20.50 +/- 5.00 fmol/g KP in human coronary artery and aorta, respectively.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  3. 07LabEndogenous levelEx vivo tissueMechanism

    In human coronary artery and aorta tissue, radioimmunoassay detected kisspeptin at 13.04 and 20.50 fmol/g, respectively.

    In plain wordsIn lab tests on human artery tissue, the body's own kisspeptin was found in coronary artery and aorta.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableKisspeptin content of human coronary artery and aorta
    Study

    humann: not reported in source

    human coronary artery and aorta tissue
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Measurements

    Kisspeptin content
    13.04 fmol/g
    coronary artery
    Kisspeptin content
    20.5 fmol/g
    aorta

    Source sentences

    Summary
    RIA detected 13.04 +/- 2.94 and 20.50 +/- 5.00 fmol/g KP in human coronary artery and aorta, respectively.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  4. 08LabEndogenous levelEx vivo tissueMechanism

    In human vessel sections, confocal microscopy showed colocalization of the receptor and the peptide in vascular endothelial cells and in the atherosclerotic plaque of coronary artery.

    In plain wordsIn lab tests on human artery tissue, the body's own kisspeptin and its receptor were found together in the vessel lining and in plaque.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableLocalisation of kisspeptin and its receptor in vessels
    Study

    humann: not reported in source

    human aorta and coronary artery sections
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    using confocal microscopy, we found colocalization of receptor and peptide to vascular endothelial cells and to the atherosclerotic plaque of coronary artery.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 3NCT03286517

Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.

Ghulam Nabin = 3026 Jun 2014 to 5 Mar 2015

Reproductive Physiological Phenomena

Trial pageClinicalTrials.govUpdated 18 Sept 2017

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    10 Oct 2026, 09:43 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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