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Study · Animal study (in vivo) · rat · 2026

5 results

Semaglutide, tirzepatide, and retatrutide attenuate the interoceptive effects of alcohol in male and female rats.

Windram M, Lovelock DF, Carew JM, Krieman CG, Hendershot CS, Besheer J

Psychopharmacology23 Jul 2025Cited by 2 (Europe PMC)

PMID40699363 (opens in a new tab)PMCIDPMC13242451 (opens in a new tab)DOI10.1007/s00213-025-06854-3 (opens in a new tab)PepBankPUB-40699363
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male and female rats, acute retatrutide attenuated discrimination of the interoceptive effects of alcohol.

    In plain wordsIn rats, acute retatrutide reduced how well the rats recognised the effects of alcohol.

    Peptide
    Retatrutide
    Outcome
    DecreaseAlcohol discrimination (interoceptive effects of alcohol)
    Study

    ratn: not reported in source

    Operant alcohol drug discrimination
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Acute administration of semaglutide, tirzepatide, and retatrutide each attenuated alcohol discrimination
    1 context sentence
    Summary · context
    We also evaluated acute treatment with tirzepatide, a dual GLP-1/gastric inhibitory peptide (GIP) receptor agonist, and retatrutide, a triple GIP/GLP-1/glucagon receptor agonist, to determine whether broader receptor activity would differentially influence alcohol's subjective effects.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male and female rats, acute semaglutide attenuated discrimination of alcohol's interoceptive effects.

    In plain wordsIn rats, semaglutide given acutely weakened the animals' recognition of the effects of alcohol.

    Peptide
    Semaglutide
    Outcome
    DecreaseAlcohol discrimination after acute dosing
    Study

    ratn: not reported in source

    Operant alcohol drug discrimination
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Acute administration of semaglutide, tirzepatide, and retatrutide each attenuated alcohol discrimination, suggesting modulation of subjective alcohol effects.
    1 context sentence
    Summary · context
    This study used operant drug discrimination in male and female rats to assess how acute and repeated semaglutide treatment affects alcohol's discriminative stimulus (interoceptive) effects.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male and female rats, acute tirzepatide attenuated discrimination of alcohol's interoceptive effects.

    In plain wordsIn rats, tirzepatide given acutely weakened the animals' recognition of the effects of alcohol.

    Peptide
    Tirzepatide
    Outcome
    DecreaseAlcohol discrimination after acute dosing
    Study

    ratn: not reported in source

    Operant alcohol drug discrimination
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Acute administration of semaglutide, tirzepatide, and retatrutide each attenuated alcohol discrimination, suggesting modulation of subjective alcohol effects.
    1 context sentence
    Summary · context
    This study used operant drug discrimination in male and female rats to assess how acute and repeated semaglutide treatment affects alcohol's discriminative stimulus (interoceptive) effects.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, repeated semaglutide kept attenuating alcohol discrimination across the 15-day treatment period.

    In plain wordsIn rats, semaglutide kept weakening recognition of alcohol's effects over 15 days of treatment.

    Peptide
    Semaglutide
    Outcome
    DecreaseAlcohol discrimination during repeated dosing
    Study

    ratn: not reported in source

    Operant alcohol drug discrimination
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated · 15 daysAs given in this study (rat).

    Source sentences

    Summary
    Repeated semaglutide maintained efficacy across the 15-day treatment period
    1 context sentence
    Summary · context
    This study used operant drug discrimination in male and female rats to assess how acute and repeated semaglutide treatment affects alcohol's discriminative stimulus (interoceptive) effects.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, alcohol discrimination returned to control levels three days after repeated semaglutide treatment stopped.

    In plain wordsIn rats, recognition of alcohol's effects went back to normal three days after semaglutide treatment stopped.

    Peptide
    Semaglutide
    Outcome
    No significant changeAlcohol discrimination after stopping semaglutide
    Study

    ratn: not reported in source

    Operant alcohol drug discrimination
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    alcohol discrimination returned to control levels three days after treatment cessation.
    1 context sentence
    Summary · context
    This study used operant drug discrimination in male and female rats to assess how acute and repeated semaglutide treatment affects alcohol's discriminative stimulus (interoceptive) effects.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 39Current

    28 Oct 2026, 02:04 UTC

    The same notice was added 36 times, first on 9 Oct 2026, 18:17 UTC. The status did not change between them.

    Study results updated

  2. Versions 2 to 3

    9 Oct 2026, 03:07 UTC

    The same notice was added 2 times, first on 9 Oct 2026, 03:06 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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