A systematic review in effects of glucagon-like peptide-1 (GLP-1) mono-agonists on functional connectivity: Target engagement and rationale for the development in mental disorders.

Au HCT, Zheng YJ, Le GH, Wong S, Phan L, Teopiz KM, Kwan ATH, Rhee TG, Rosenblat JD, Ho R, McIntyre RS

Journal of affective disorders7 Nov 2024Cited by 22 (Europe PMC)

PMID39515485DOI10.1016/j.jad.2024.11.019PepBankPUB-39515485

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

1 result from studies that gave the peptide. 1 result from people.

01HumanSystematic reviewMechanism
In reviewed healthy adults, liraglutide was associated with increased hippocampal functional connectivity; the exact comparison was unstated.
In plain wordsIn reviewed healthy adults, liraglutide was linked to higher hippocampal connectivity; its comparison was unspecified.
Peptide
Liraglutide
Outcome
IncreaseHippocampal functional connectivity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Moreover, liraglutide is associated with increased functional connectivity within the hippocampus in healthy individuals suggesting that GLP-1RAs may have differential effects on brain functional connectivity.
3 context sentences(design, population, supporting numbers)
Summary · context
We conducted a systematic review examining studies that investigate changes in functional connectivity mediated by GLP-1 and GLP-1RAs in human adults.
Summary · context
Relevant articles were retrieved from OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to April 26, 2024.
Summary · context
Primary or secondary studies (n = 8) investigating the role of GLP-1 and GLP-1RAs on functional connectivity were included for analysis.
Report a problemFND-3951548508

Studies that did not test the peptide alone7

In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Liraglutide.

02HumanNot a test of Liraglutide aloneSystematic reviewMechanism
In reviewed human adults, pooled GLP-1 and GLP-1 receptor agonist evidence showed dorsal default mode network connectivity modulation; direction and reference were unstated.
In plain wordsIn reviewed adults, pooled GLP-1 evidence showed dorsal default mode network connectivity changes; direction and comparison were unspecified.
Peptide
Liraglutide
Outcome
Direction not reportedDorsal default mode network functional connectivity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GLP-1 and GLP-1RAs modulate functional connectivity within the dorsal default mode network (DMN), visuospatial network, right frontal parietal network, and the salience network.
3 context sentences(design, population, supporting numbers)
Summary · context
We conducted a systematic review examining studies that investigate changes in functional connectivity mediated by GLP-1 and GLP-1RAs in human adults.
Summary · context
Relevant articles were retrieved from OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to April 26, 2024.
Summary · context
Primary or secondary studies (n = 8) investigating the role of GLP-1 and GLP-1RAs on functional connectivity were included for analysis.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3951548501
03HumanNot a test of Liraglutide aloneSystematic reviewMechanism
In reviewed human adults, pooled GLP-1 and GLP-1 receptor agonist evidence showed visuospatial network connectivity modulation; direction and reference were unstated.
In plain wordsIn reviewed adults, pooled GLP-1 evidence showed visuospatial network connectivity changes; direction and comparison were unspecified.
Peptide
Liraglutide
Outcome
Direction not reportedVisuospatial network functional connectivity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GLP-1 and GLP-1RAs modulate functional connectivity within the dorsal default mode network (DMN), visuospatial network, right frontal parietal network, and the salience network.
3 context sentences(design, population, supporting numbers)
Summary · context
We conducted a systematic review examining studies that investigate changes in functional connectivity mediated by GLP-1 and GLP-1RAs in human adults.
Summary · context
Relevant articles were retrieved from OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to April 26, 2024.
Summary · context
Primary or secondary studies (n = 8) investigating the role of GLP-1 and GLP-1RAs on functional connectivity were included for analysis.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3951548502
04HumanNot a test of Liraglutide aloneSystematic reviewMechanism
In reviewed human adults, pooled GLP-1 and GLP-1 receptor agonist evidence showed right frontal parietal network connectivity modulation; direction and reference were unstated.
In plain wordsIn reviewed adults, pooled GLP-1 evidence showed right frontal parietal network connectivity changes; direction and comparison were unspecified.
Peptide
Liraglutide
Outcome
Direction not reportedRight frontal parietal network functional connectivity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GLP-1 and GLP-1RAs modulate functional connectivity within the dorsal default mode network (DMN), visuospatial network, right frontal parietal network, and the salience network.
3 context sentences(design, population, supporting numbers)
Summary · context
We conducted a systematic review examining studies that investigate changes in functional connectivity mediated by GLP-1 and GLP-1RAs in human adults.
Summary · context
Relevant articles were retrieved from OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to April 26, 2024.
Summary · context
Primary or secondary studies (n = 8) investigating the role of GLP-1 and GLP-1RAs on functional connectivity were included for analysis.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3951548503
05HumanNot a test of Liraglutide aloneSystematic reviewMechanism
In reviewed human adults, pooled GLP-1 and GLP-1 receptor agonist evidence showed salience network connectivity modulation; direction and reference were unstated.
In plain wordsIn reviewed adults, pooled GLP-1 evidence showed salience network connectivity changes; direction and comparison were unspecified.
Peptide
Liraglutide
Outcome
Direction not reportedSalience network functional connectivity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GLP-1 and GLP-1RAs modulate functional connectivity within the dorsal default mode network (DMN), visuospatial network, right frontal parietal network, and the salience network.
3 context sentences(design, population, supporting numbers)
Summary · context
We conducted a systematic review examining studies that investigate changes in functional connectivity mediated by GLP-1 and GLP-1RAs in human adults.
Summary · context
Relevant articles were retrieved from OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to April 26, 2024.
Summary · context
Primary or secondary studies (n = 8) investigating the role of GLP-1 and GLP-1RAs on functional connectivity were included for analysis.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3951548504
06HumanNot a test of Liraglutide aloneSystematic reviewMechanism
In reviewed human adults, pooled GLP-1 agonism was associated with decreased functional connectivity in the hypothalamus; exact reference was unstated.
In plain wordsIn reviewed adults, pooled GLP-1 evidence was linked to lower hypothalamus connectivity; its comparison was unspecified.
Peptide
Liraglutide
Outcome
DecreaseHypothalamic functional connectivity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GLP-1 agonism is also associated with decreased functional connectivity within the hypothalamus, lateral orbitofrontal cortex, and amygdala.
3 context sentences(design, population, supporting numbers)
Summary · context
We conducted a systematic review examining studies that investigate changes in functional connectivity mediated by GLP-1 and GLP-1RAs in human adults.
Summary · context
Relevant articles were retrieved from OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to April 26, 2024.
Summary · context
Primary or secondary studies (n = 8) investigating the role of GLP-1 and GLP-1RAs on functional connectivity were included for analysis.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3951548505
07HumanNot a test of Liraglutide aloneSystematic reviewMechanism
In reviewed human adults, pooled GLP-1 agonism was associated with decreased functional connectivity in the lateral orbitofrontal cortex; exact reference was unstated.
In plain wordsIn reviewed adults, pooled GLP-1 evidence was linked to lower lateral orbitofrontal cortex connectivity; its comparison was unspecified.
Peptide
Liraglutide
Outcome
DecreaseLateral orbitofrontal cortex functional connectivity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GLP-1 agonism is also associated with decreased functional connectivity within the hypothalamus, lateral orbitofrontal cortex, and amygdala.
3 context sentences(design, population, supporting numbers)
Summary · context
We conducted a systematic review examining studies that investigate changes in functional connectivity mediated by GLP-1 and GLP-1RAs in human adults.
Summary · context
Relevant articles were retrieved from OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to April 26, 2024.
Summary · context
Primary or secondary studies (n = 8) investigating the role of GLP-1 and GLP-1RAs on functional connectivity were included for analysis.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3951548506
08HumanNot a test of Liraglutide aloneSystematic reviewMechanism
In reviewed human adults, pooled GLP-1 agonism was associated with decreased functional connectivity in the amygdala; exact reference was unstated.
In plain wordsIn reviewed adults, pooled GLP-1 evidence was linked to lower amygdala connectivity; its comparison was unspecified.
Peptide
Liraglutide
Outcome
DecreaseAmygdala functional connectivity
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
GLP-1 agonism is also associated with decreased functional connectivity within the hypothalamus, lateral orbitofrontal cortex, and amygdala.
3 context sentences(design, population, supporting numbers)
Summary · context
We conducted a systematic review examining studies that investigate changes in functional connectivity mediated by GLP-1 and GLP-1RAs in human adults.
Summary · context
Relevant articles were retrieved from OVID (MedLine, Embase, AMED, PsychINFO, JBI EBP Database), PubMed, and Web of Science from database inception to April 26, 2024.
Summary · context
Primary or secondary studies (n = 8) investigating the role of GLP-1 and GLP-1RAs on functional connectivity were included for analysis.
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3951548507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
12 Oct 2026, 11:11 UTC
Study results updated
Versions 2 to 3
9 Oct 2026, 03:07 UTC
The same notice was added 2 times, first on 9 Oct 2026, 03:06 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:05 UTC
First added · source update from Europe PMC

A systematic review in effects of glucagon-like peptide-1 (GLP-1) mono-agonists on functional connectivity: Target engagement and rationale for the development in mental disorders.

Summary

Results from this study8

Studies that did not test the peptide alone7

Version history

Subjects

Publication types

MeSH terms

Keywords