Peptides / Skin and hair

Synthetic analog · 4 amino acids · 530.6 Da

Tripeptide-10 citrulline

Tripeptide-10 citrulline is a cosmetic peptide that mimics decorin, used in skin products marketed for suppleness, not an approved drug. A study in people compared it with acetyl hexapeptide-3 on skin measures, and lab studies looked at how it affects collagen fibers. PepBank shows 10 results on tripeptide-10 citrulline from 1 study in people, and 4 from animal and lab studies. The strongest evidence is a randomized trial in people. Data as of 2026-10-30.

Also known as Decorinyl, tripeptide 10 citrulline

4 amino acids, from first to lastKDIX

Evidence level: Some studies in people10 of 14 results come from studies in people.

Results in people

71% of 14 results

Results in animals

0% of 14 results

Results in lab cells

29% of 14 results

From computer models

0% of 14 results

Overview

Tripeptide-10 citrulline at a glance

What it is	Synthetic analog, 4 amino acids
Approval	Regulatory status not recorded
In sport	Status unknown
Studies	2 studies with results. Both of them gave tripeptide-10 citrulline, with 14 results. 10 in people4 in lab cells
Best study in people	Randomized controlled trial (2017)
Clinical trials	None registered
Community use	Cosmetic creams and serums marketed for skin suppleness

The science

What is tripeptide-10 citrulline?

A decorin-mimetic cosmetic ingredient used in products marketed for skin suppleness.

Amino acids in one chain

Tripeptide-10 citrulline structure and chemistry

The key facts about the molecule. Long codes are in the closed section below.

Sequence, 4 amino acidsFrom the first amino acid to the last

+K1−DIX

Darker means more water-repelling+ and − show charge in the bodyOutlined: changed amino acid

Structure

Tripeptide-10 citrulline is a synthetic analog of 4 amino acids, with no ring, 2 changed amino acids.

Formula

C₂₂H₄₂N₈O₇

Molecular weight

530.6 g/mol

CAS number

960531-53-7

Development

Lipotec / Lubrizol. Highest phase: unknown.

Identifiers

PubChem 90479646, UNII 2732R0E76W

Full sequence, SMILES and InChIKey

Three-letter sequence
Lys-Asp-Ile-Cit

InChIKey
GKPMARPRXONRJX-BWJWTDLKSA-N

SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)N

See charge, composition and 3D structure on the Scientific page

The evidence

What tripeptide-10 citrulline studies show

Results grouped by what the studies measured. Each card shows where its results come from.

Some studies in people10 of 14 results come from studies in people.

Skin, hair and wounds

14 results · 10 in people · 4 lab

In healthy volunteers, tripeptide-10 citrulline and acetyl hexapeptide-3 differed in cR2 change after 20 days. Journal of cosmetic dermatology, 2017

All 1 study in people

In people

In healthy volunteers, tripeptide-10 citrulline and acetyl hexapeptide-3 differed in cR2 change after 20 days.

2017Journal of cosmetic dermatology

All 2 tripeptide-10 citrulline studies by area Open the Scientific page

Key tripeptide-10 citrulline studies

Studies in people come first, then studies in animals and in the lab.

People
The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Raikou et al. 2017 · Journal of cosmetic dermatology · cited by 15
10 results
Lab cells
A new decorin-like tetrapeptide for optimal organization of collagen fibres
Puig et al. 2008 · International journal of cosmetic science · cited by 24
4 results

All 2 Tripeptide-10 citrulline studies

Tripeptide-10 citrulline clinical trials

ClinicalTrials.gov lists no trial of tripeptide-10 citrulline. A trial under another name may exist.

Status and safety

Is tripeptide-10 citrulline approved?

FDA

United States

Status unknown

Status unknown.

EMA

European Union

Status unknown

Status unknown.

WADA

Sport

Not recorded

Status unknown.

Regulatory status not recorded. Status unknown.

Laws and labels change, so check the regulator for the current status.

Tripeptide-10 citrulline side effects and safety

PepBank has no safety result from studies of tripeptide-10 citrulline yet. That does not mean tripeptide-10 citrulline is safe.

From the community

How people use it

What people report online. It comes from forums and guides, not from studies.

Community-reported. Not tested in trials.

A non-vendor affiliate guide describes topical cosmetic use in creams and serums. This report does not establish clinical efficacy or safety.

Reported routines and cautions

What people use it for

Cosmetic creams and serums marketed for skin supplenessS1

Reported regimens

Regimens that community sources report for Tripeptide-10 citrulline. Community-reported, not tested in trials.
Context	Route	Amount	How often	How long	Agreement	Sources
Cosmetic creams and serums marketed for skin suppleness	topical	Not stated	Not stated	Not stated	Single source. The source carries commercial or referral links. Its underlying reports were not independently confirmed.	S1

Community sources

S1Tripeptide-10 citrulline topical-use guidepeptidedecoding.comcarries seller links, not linked

Gaps

The source does not establish product identity, independent outcomes or a safe regimen.

Questions and more

Ask a question about tripeptide-10 citrulline

The answer links to every study it uses.

What does the evidence say about tripeptide-10 citrulline?Is tripeptide-10 citrulline tested in people?Compare with Difelikefalin Compare with Argireline (acetyl hexapeptide-8)

Sources

Database: PepBank data for tripeptide-10 citrulline (data version 308560)
Regulator: FDA status record
Regulator: EMA status record
Regulator: WADA status record
Community: community sources (forums and guides), as summarized in the PepBank community file

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Ask your AI about tripeptide-10 citrulline

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Tripeptide-10 citrulline

Also known as Decorinyl, tripeptide 10 citrulline

What it is

Synthetic analog, 4 amino acids

Approval

Regulatory status not recorded

In sport

Status unknown

Studies

2 studies with results. Both of them gave tripeptide-10 citrulline, with 14 results.
10 in people4 in lab cells

Best study in people

Randomized controlled trial (2017)

Clinical trials

None registered

Community use

Cosmetic creams and serums marketed for skin suppleness

Context

Route

Amount

How often

How long

Agreement

Sources

Cosmetic creams and serums marketed for skin suppleness

topical

Not stated

Single source. The source carries commercial or referral links. Its underlying reports were not independently confirmed.

Tripeptide-10 citrulline

Tripeptide-10 citrulline at a glance

What is tripeptide-10 citrulline?

Tripeptide-10 citrulline structure and chemistry