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Study · Randomized controlled trial · 2017

28 results

The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study.

Raikou V, Varvaresou A, Panderi I, Panderi I, Papageorgiou E

Journal of cosmetic dermatology2 Feb 2017Cited by 15 (Europe PMC)

PMID28150423 (opens in a new tab)DOI10.1111/jocd.12314 (opens in a new tab)PepBankPUB-28150423
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study28

21 results from studies that gave the peptide. 21 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR2 change differed between the peptide combination and tripeptide-10 citrulline alone after 20 days.

    In plain wordsIn healthy volunteers, cR2 change differed between the combination and tripeptide-10 citrulline alone after 20 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR2 at 20 days: combination versus tripeptide alone
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 20 daysAs given in this study (human).

    Measurements

    P value
    0.045
    cR2 P, G1 vs G2, 20 days

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044)
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR3 change differed between the peptide combination and tripeptide-10 citrulline alone after 20 days.

    In plain wordsIn healthy volunteers, cR3 change differed between the combination and tripeptide-10 citrulline alone after 20 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR3 at 20 days: combination versus tripeptide alone
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 20 daysAs given in this study (human).

    Measurements

    P value
    0.044
    cR3 P, G1 vs G2, 20 days

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044)
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR2 change differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 20 days.

    In plain wordsIn healthy volunteers, cR2 change differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 20 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR2 at 20 days: acetyl hexapeptide versus tripeptide
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 20 daysAs given in this study (human).

    Measurements

    P value
    0.017
    cR2 P, G2 vs G3, 20 days

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044), G2 and G3 groups (cR2 P=.017, cR3 P=.017), G3 and G4 groups (CR2 P=.022), and G2 and G4 groups (cR3 P=.028) from baseline were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR3 change differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 20 days.

    In plain wordsIn healthy volunteers, cR3 change differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 20 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR3 at 20 days: acetyl hexapeptide versus tripeptide
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 20 daysAs given in this study (human).

    Measurements

    P value
    0.017
    cR3 P, G2 vs G3, 20 days

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044), G2 and G3 groups (cR2 P=.017, cR3 P=.017), G3 and G4 groups (CR2 P=.022), and G2 and G4 groups (cR3 P=.028) from baseline were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR2 change differed between acetyl hexapeptide-3 alone and neither peptide after 20 days.

    In plain wordsIn healthy volunteers, cR2 change differed between acetyl hexapeptide-3 alone and neither peptide after 20 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR2 at 20 days: acetyl hexapeptide versus neither peptide
    Study

    n: not reported in source

    Comparator
    Neither peptide (G4)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 20 daysAs given in this study (human).

    Measurements

    P value
    0.022
    cR2 P, G3 vs G4, 20 days

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044), G2 and G3 groups (cR2 P=.017, cR3 P=.017), G3 and G4 groups (CR2 P=.022), and G2 and G4 groups (cR3 P=.028) from baseline were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR2 differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 60 days.

    In plain wordsIn healthy volunteers, cR2 differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 60 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR2 at 60 days: acetyl hexapeptide versus tripeptide
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.044
    cR2 P, G2 vs G3, 60 days

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR3 differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 60 days.

    In plain wordsIn healthy volunteers, cR3 differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 60 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR3 at 60 days: acetyl hexapeptide versus tripeptide
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.044
    cR3 P, G2 vs G3, 60 days

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, TEWL change differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 20 days.

    In plain wordsIn healthy volunteers, water loss change differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 20 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedTEWL at 20 days: acetyl hexapeptide versus tripeptide
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 20 daysAs given in this study (human).

    Source sentences

    Summary
    After 20 days, changes in TEWL between groups G1 and G3 (P=.03), groups G2 and G3 (P=.045), and groups G3 and G4 (P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  9. 09HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, TEWL change differed between acetyl hexapeptide-3 alone and neither peptide after 20 days.

    In plain wordsIn healthy volunteers, water loss change differed between acetyl hexapeptide-3 alone and neither peptide after 20 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedTEWL at 20 days: acetyl hexapeptide versus neither peptide
    Study

    n: not reported in source

    Comparator
    Neither peptide (G4)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 20 daysAs given in this study (human).

    Source sentences

    Summary
    After 20 days, changes in TEWL between groups G1 and G3 (P=.03), groups G2 and G3 (P=.045), and groups G3 and G4 (P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  10. 10HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, TEWL change differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 40 days.

    In plain wordsIn healthy volunteers, water loss change differed between acetyl hexapeptide-3 alone and tripeptide-10 citrulline alone after 40 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedTEWL at 40 days: acetyl hexapeptide versus tripeptide
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 40 daysAs given in this study (human).

    Source sentences

    Summary
    After 40 days, changes between groups G2 and G3 (P=.028) and groups G3 and G4 (P=.01) from baseline were significant.
    2 context sentences
    Summary · context
    After 20 days, changes in TEWL between groups G1 and G3 (P=.03), groups G2 and G3 (P=.045), and groups G3 and G4 (P=.025) were significant.
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  11. 11HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, TEWL change differed between acetyl hexapeptide-3 alone and neither peptide after 40 days.

    In plain wordsIn healthy volunteers, water loss change differed between acetyl hexapeptide-3 alone and neither peptide after 40 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedTEWL at 40 days: acetyl hexapeptide versus neither peptide
    Study

    n: not reported in source

    Comparator
    Neither peptide (G4)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 40 daysAs given in this study (human).

    Source sentences

    Summary
    After 40 days, changes between groups G2 and G3 (P=.028) and groups G3 and G4 (P=.01) from baseline were significant.
    2 context sentences
    Summary · context
    After 20 days, changes in TEWL between groups G1 and G3 (P=.03), groups G2 and G3 (P=.045), and groups G3 and G4 (P=.025) were significant.
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  12. 12HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, tripeptide-10 citrulline differed significantly from acetyl hexapeptide-3 in cR2 change at 20 days.

    In plain wordsIn healthy volunteers, tripeptide-10 citrulline and acetyl hexapeptide-3 differed in cR2 change after 20 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR2 at 20 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.017
    G2 versus G3 cR2

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044), G2 and G3 groups (cR2 P=.017, cR3 P=.017), G3 and G4 groups (CR2 P=.022), and G2 and G4 groups (cR3 P=.028) from baseline were significant.
  13. 13HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, tripeptide-10 citrulline differed significantly from acetyl hexapeptide-3 in cR3 change at 20 days.

    In plain wordsIn healthy volunteers, tripeptide-10 citrulline and acetyl hexapeptide-3 differed in cR3 change after 20 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR3 at 20 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.017
    G2 versus G3 cR3

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044), G2 and G3 groups (cR2 P=.017, cR3 P=.017), G3 and G4 groups (CR2 P=.022), and G2 and G4 groups (cR3 P=.028) from baseline were significant.
  14. 14HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, the cR3 change from baseline at 20 days differed significantly between tripeptide-10 citrulline alone and the group given neither peptide.

    In plain wordsIn healthy volunteers, the cR3 change at 20 days differed between tripeptide-10 citrulline alone and no peptide.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR3 at 20 days
    Study

    n: not reported in source

    Comparator
    Neither peptide (G4)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.028
    G2 versus G4 cR3

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044), G2 and G3 groups (cR2 P=.017, cR3 P=.017), G3 and G4 groups (CR2 P=.022), and G2 and G4 groups (cR3 P=.028) from baseline were significant.
  15. 15HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, adding tripeptide-10 citrulline to acetyl hexapeptide-3 produced a significant cR2 difference at 60 days.

    In plain wordsIn healthy volunteers, cR2 differed between the peptide combination and acetyl hexapeptide-3 alone after 60 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR2 at 60 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.016
    G1 versus G3 cR2

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025)
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  16. 16HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, adding tripeptide-10 citrulline to acetyl hexapeptide-3 produced a significant cR3 difference at 60 days.

    In plain wordsIn healthy volunteers, cR3 differed between the peptide combination and acetyl hexapeptide-3 alone after 60 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR3 at 60 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.025
    G1 versus G3 cR3

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025)
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  17. 17HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, tripeptide-10 citrulline differed significantly from acetyl hexapeptide-3 in cR2 at 60 days.

    In plain wordsIn healthy volunteers, cR2 differed between tripeptide-10 citrulline and acetyl hexapeptide-3 after 60 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR2 at 60 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.044
    G2 versus G3 cR2

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant.
  18. 18HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, tripeptide-10 citrulline differed significantly from acetyl hexapeptide-3 in cR3 at 60 days.

    In plain wordsIn healthy volunteers, cR3 differed between tripeptide-10 citrulline and acetyl hexapeptide-3 after 60 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR3 at 60 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.044
    G2 versus G3 cR3

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant.
  19. 19HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, adding tripeptide-10 citrulline to acetyl hexapeptide-3 produced a significant TEWL change difference at 20 days.

    In plain wordsIn healthy volunteers, skin water loss changes differed between the peptide combination and acetyl hexapeptide-3 alone after 20 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedTEWL change at 20 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.03
    G1 versus G3 TEWL

    Source sentences

    Summary
    After 20 days, changes in TEWL between groups G1 and G3 (P=.03)
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  20. 20HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, tripeptide-10 citrulline differed significantly from acetyl hexapeptide-3 in TEWL change at 20 days.

    In plain wordsIn healthy volunteers, skin water loss changes differed between tripeptide-10 citrulline and acetyl hexapeptide-3 after 20 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedTEWL change at 20 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.045
    G2 versus G3 TEWL

    Source sentences

    Summary
    After 20 days, changes in TEWL between groups G1 and G3 (P=.03), groups G2 and G3 (P=.045), and groups G3 and G4 (P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.
  21. 21HumanRandomized controlled trialEfficacy outcome

    In healthy volunteers, tripeptide-10 citrulline differed significantly from acetyl hexapeptide-3 in TEWL change at 40 days.

    In plain wordsIn healthy volunteers, skin water loss changes differed between tripeptide-10 citrulline and acetyl hexapeptide-3 after 40 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedTEWL change at 40 days
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · 60 daysAs given in this study (human).

    Measurements

    P value
    0.028
    G2 versus G3 TEWL

    Source sentences

    Summary
    After 40 days, changes between groups G2 and G3 (P=.028) and groups G3 and G4 (P=.01) from baseline were significant.
    2 context sentences
    Summary · context
    After 20 days, changes in TEWL between groups G1 and G3 (P=.03)
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.

Studies that did not test the peptide alone7

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 22HumanNot a test of Argireline (acetyl hexapeptide-8) aloneRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR2 differed between the peptide combination and acetyl hexapeptide-3 alone after 60 days.

    In plain wordsIn healthy volunteers, cR2 differed between the combination and acetyl hexapeptide-3 alone after 60 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR2 at 60 days: combination versus acetyl hexapeptide
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    P value
    0.016
    cR2 P, G1 vs G3, 60 days

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  2. 23HumanNot a test of Argireline (acetyl hexapeptide-8) aloneRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR3 differed between the peptide combination and acetyl hexapeptide-3 alone after 60 days.

    In plain wordsIn healthy volunteers, cR3 differed between the combination and acetyl hexapeptide-3 alone after 60 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR3 at 60 days: combination versus acetyl hexapeptide
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    P value
    0.025
    cR3 P, G1 vs G3, 60 days

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  3. 24HumanNot a test of Argireline (acetyl hexapeptide-8) aloneRandomized controlled trialEfficacy outcome

    In healthy volunteers, cR2 differed between the peptide combination and neither peptide after 60 days.

    In plain wordsIn healthy volunteers, cR2 differed between the combination and neither peptide after 60 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedcR2 at 60 days: combination versus neither peptide
    Study

    n: not reported in source

    Comparator
    Neither peptide (G4)
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    P value
    0.025
    cR2 P, G1 vs G4, 60 days

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  4. 25HumanNot a test of Argireline (acetyl hexapeptide-8) aloneRandomized controlled trialEfficacy outcome

    In healthy volunteers, TEWL change differed between the peptide combination and acetyl hexapeptide-3 alone after 20 days.

    In plain wordsIn healthy volunteers, water loss change differed between the combination and acetyl hexapeptide-3 alone after 20 days.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    Direction not reportedTEWL at 20 days: combination versus acetyl hexapeptide
    Study

    n: not reported in source

    Comparator
    Acetyl hexapeptide-3 alone (G3)
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    P value
    0.03
    TEWL P, G1 vs G3, 20 days

    Source sentences

    Summary
    After 20 days, changes in TEWL between groups G1 and G3 (P=.03), groups G2 and G3 (P=.045), and groups G3 and G4 (P=.025) were significant.
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  5. 26HumanNot a test of Tripeptide-10 citrulline aloneRandomized controlled trialEfficacy outcome

    In healthy volunteers, the peptide combination differed significantly from tripeptide-10 citrulline alone in cR2 change at 20 days.

    In plain wordsIn healthy volunteers, the peptide combination and tripeptide-10 citrulline alone differed in cR2 change after 20 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR2 at 20 days
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    P value
    0.045
    G1 versus G2 cR2

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044)
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.

    In this study, Tripeptide-10 citrulline was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tripeptide-10 citrulline.

  6. 27HumanNot a test of Tripeptide-10 citrulline aloneRandomized controlled trialEfficacy outcome

    In healthy volunteers, the peptide combination differed significantly from tripeptide-10 citrulline alone in cR3 change at 20 days.

    In plain wordsIn healthy volunteers, the peptide combination and tripeptide-10 citrulline alone differed in cR3 change after 20 days.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR3 at 20 days
    Study

    n: not reported in source

    Comparator
    Tripeptide-10 citrulline alone (G2)
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    P value
    0.044
    G1 versus G2 cR3

    Source sentences

    Summary
    After 20 days, the measurements between G1 and G2 groups (cR2 P=.045, cR3 P=.044)
    1 context sentence
    Summary · context
    Twenty-four healthy volunteers were randomized to receive combination of acetyl hexapeptide-3 with tripeptide-10 citrulline (Group G1), tripeptide-10 citrulline (Group, G2), acetyl hexapeptide-3 (Group G3), or neither peptide (Group G4) for 60 days.

    In this study, Tripeptide-10 citrulline was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tripeptide-10 citrulline.

  7. 28HumanNot a test of Tripeptide-10 citrulline aloneRandomized controlled trialEfficacy outcome

    In healthy volunteers, the cR2 change from baseline at 60 days differed significantly between the acetyl hexapeptide-3 plus tripeptide-10 citrulline combination and the group given neither peptide.

    In plain wordsIn healthy volunteers, the cR2 change at 60 days differed between the two-peptide combination and no peptide.

    Peptide
    Tripeptide-10 citrulline
    Outcome
    Direction not reportedcR2 at 60 days
    Study

    n: not reported in source

    Comparator
    Neither peptide (G4)
    Outcome group
    Skin and hair · Skin and wound

    Measurements

    P value
    0.025
    G1 versus G4 cR2

    Source sentences

    Summary
    After 60 days, measurements between groups G1 and G3 (cR2 P=.016, cR3 P=.025), groups G2 and G3 (cR2 P=.044, cR3= P=.044), and groups G1 and G4 (cR2 P=.025) were significant.

    In this study, Tripeptide-10 citrulline was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tripeptide-10 citrulline.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:25 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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