Peptides / Skin and hair

Synthetic analog · 3 amino acids · 495.6 Da

SYN-AKE

SYN-AKE, or dipeptide diaminobutyroyl benzylamide diacetate, is a synthetic cosmetic peptide used in products marketed for expression lines, not an approved drug. Lab studies tested it mostly for safety, antioxidant activity and effects on skin cells. PepBank shows 8 results on SYN-AKE from animal and lab studies. No study in people has reported results yet. Data as of 2026-10-30.

3 amino acids, from first to lastXPX

Evidence level: Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.

Results in people

0% of 8 results

Results in animals

0% of 8 results

Results in lab cells

100% of 8 results

From computer models

0% of 8 results

Overview

SYN-AKE at a glance

What it is	Synthetic analog, 3 amino acids
Approval	Regulatory status not recorded
In sport	Status unknown
Studies	3 studies with results. 2 of them gave SYN-AKE, with 8 results. 8 in lab cells
Clinical trials	None registered
Community use	Cosmetic products for expression lines

The science

What is SYN-AKE?

A synthetic cosmetic peptide mimic used in products marketed for expression lines.

Amino acids in one chain

SYN-AKE structure and chemistry

The key facts about the molecule. Long codes are in the closed section below.

Sequence, 3 amino acidsFrom the first amino acid to the last

X1PX

Darker means more water-repelling+ and − show charge in the bodyOutlined: changed amino acid

Structure

SYN-AKE is a synthetic analog of 3 amino acids, with no ring, 3 changed amino acids.

Formula

C₂₃H₃₇N₅O₇

Molecular weight

495.6 g/mol

CAS number

823202-99-9

Target

Muscle-type nicotinic acetylcholine receptor: antagonist

Development

DSM-firmenich (current supplier). Highest phase: unknown.

Identifiers

PubChem 71465152, UNII 38H206R00R

Full sequence, SMILES and InChIKey

Three-letter sequence
beta-Ala-L-Pro-L-Dab-NH-Bzl

InChIKey
HSUGRPOJOBRRBK-SXBSVMRRSA-N

SMILES
CC(=O)O.CC(=O)O.C1C[C@H](N(C1)C(=O)CCN)C(=O)N[C@@H](CCN)C(=O)NCC2=CC=CC=C2

See charge, composition and 3D structure on the Scientific page

The evidence

What SYN-AKE studies show

Results grouped by what the studies measured. Each card shows where its results come from.

Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.

Skin, hair and wounds

3 results · 3 lab

In lab tests, the Syn‑Ake nanoemulsion formulation protected cells and DNA against peroxide and ultraviolet damage. 3 Biotech, 2026

Cells, genes and aging

2 results · 2 lab

In lab tests, Syn‑Ake removed more DPPH radicals as its concentration increased. Journal of biomolecular structure & dynamics, 2024

Key SYN-AKE studies

Studies in people come first, then studies in animals and in the lab.

Lab cells
Development of cosmeceutical nanoemulsion formulation containing peptide acting on neurotransmitters and evaluation of its efficacy
Gok et al. 2026 · 3 Biotech · cited by 0
6 results
Lab cells
Anti-aging activity of Syn-Ake peptide by <i>in silico</i> approaches and <i>in vitro</i> tests
Gok et al. 2024 · Journal of biomolecular structure & dynamics · cited by 9
2 results

All 3 SYN-AKE studies

SYN-AKE clinical trials

ClinicalTrials.gov lists no trial of SYN-AKE. A trial under another name may exist.

Status and safety

Is SYN-AKE approved?

FDA

United States

Status unknown

Status unknown.

EMA

European Union

Status unknown

Status unknown.

WADA

Sport

Not recorded

Status unknown.

Regulatory status not recorded. Status unknown.

Laws and labels change, so check the regulator for the current status.

SYN-AKE side effects and safety

PepBank has 3 safety results from studies of SYN-AKE. None of them come from studies in people, so they do not show what happens in people.

Safety results from studies (3)

In lab tests, the Syn‑Ake nanoemulsion formulation was non-genotoxic. (3 Biotech, 2026)
In lab tests, researchers determined a safe Syn‑Ake dose but did not report its value in the abstract. (Journal of biomolecular structure & dynamics, 2024)
In lab tests, the Syn‑Ake nanoemulsion formulation was compatible with cells. (3 Biotech, 2026)

See every safety result on the Scientific page

From the community

How people use it

What people report online. It comes from forums and guides, not from studies.

Community-reported. Not tested in trials.

The cited source reports this use. The report does not establish clinical efficacy or safety.

Reported routines and cautions

What people use it for

Cosmetic products for expression linesS1

Reported regimens

Regimens that community sources report for SYN-AKE. Community-reported, not tested in trials.
Context	Route	Amount	How often	How long	Agreement	Sources
Cosmetic products for expression lines	Not stated	3 to 5 % per formulation	Not stated	Not stated	Single non-vendor guide. Its 3–5% trade-solution report differs from the manufacturer’s 1–4% guidance. The source page showed no affiliate links.	S1

Community sources

S1SYN-AKE cosmetic guide (opens in a new tab)www.peptidex.eu

Gaps

One guide supports the retained report. Independent use reports and clinical regimen validation remain absent. Manufacturer formulation guidance differs.

Questions and more

Ask a question about SYN-AKE

The answer links to every study it uses.

What does the evidence say about SYN-AKE?Is SYN-AKE tested in people?Compare with L-carnosine Compare with Matrixyl (palmitoyl pentapeptide-4)

Sources

Database: PepBank data for SYN-AKE (data version 308560)
Regulator: FDA status record
Regulator: WADA status record
Community: community sources (forums and guides), as summarized in the PepBank community file

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Ask your AI about SYN-AKE

Curo is a peptide shop. PepBank and Curo have the same owner. See the Curo catalog (opens in a new tab).

SYN-AKE

What it is

Synthetic analog, 3 amino acids

Approval

Regulatory status not recorded

In sport

Status unknown

Studies

3 studies with results. 2 of them gave SYN-AKE, with 8 results.
8 in lab cells

Clinical trials

None registered

Community use

Cosmetic products for expression lines

Context

Route

Amount

How often

How long

Agreement

Sources

Cosmetic products for expression lines

Not stated

3 to 5 % per formulation

Not stated

Single non-vendor guide. Its 3–5% trade-solution report differs from the manufacturer’s 1–4% guidance. The source page showed no affiliate links.

SYN-AKE

SYN-AKE at a glance

What is SYN-AKE?

SYN-AKE structure and chemistry