Development of cosmeceutical nanoemulsion formulation containing peptide acting on neurotransmitters and evaluation of its efficacy.

Gok B, Budama-Kilinc Y, Kecel-Gunduz S

3 Biotech23 Oct 2026

PMID42927054DOI10.1007/s13205-026-05090-6PepBankPUB-42927054

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Safety outcome
In laboratory tests, the Syn‑Ake nanoemulsion formulation was non-genotoxic.
In plain wordsIn lab tests, the Syn‑Ake nanoemulsion formulation was non-genotoxic.
Peptide
SYN-AKE
Outcome
Direction not reportedGenotoxicity
Study
n: not reported in source
Outcome group
Adverse events · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
The formulation was determined to be non-genotoxic, cytocompatible and to have cell regenerative properties.
1 context sentence(design, population, supporting numbers)
Summary · context
The in vitro safety of the formulation was evaluated by genotoxicity and cytotoxicity studies.
Report a problemFND-4292705403
02LabIn vitro (cells)Safety outcome
In laboratory tests, the Syn‑Ake nanoemulsion formulation was cytocompatible.
In plain wordsIn lab tests, the Syn‑Ake nanoemulsion formulation was compatible with cells.
Peptide
SYN-AKE
Outcome
Direction not reportedCytocompatibility
Study
n: not reported in source
Outcome group
Adverse events · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
The formulation was determined to be non-genotoxic, cytocompatible and to have cell regenerative properties.
1 context sentence(design, population, supporting numbers)
Summary · context
The in vitro safety of the formulation was evaluated by genotoxicity and cytotoxicity studies.
Report a problemFND-4292705404
03LabIn vitro (cells)Efficacy outcome
In a scratch test, the Syn‑Ake nanoemulsion formulation showed cell regenerative properties.
In plain wordsIn cells, the Syn‑Ake nanoemulsion formulation showed regenerative properties in a scratch test.
Peptide
SYN-AKE
Outcome
Direction not reportedCell regeneration
Study
n: not reported in source
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
The formulation was determined to be non-genotoxic, cytocompatible and to have cell regenerative properties.
1 context sentence(design, population, supporting numbers)
Summary · context
The cell regenerative effect of the formulation was evaluated by scratch test.
Report a problemFND-4292705405
04LabIn vitro (cells)Efficacy outcome
In laboratory tests, the Syn‑Ake nanoemulsion formulation protected against H2O2-UV-based damage at cellular and DNA levels.
In plain wordsIn lab tests, the Syn‑Ake nanoemulsion formulation protected cells and DNA against peroxide and ultraviolet damage.
Peptide
SYN-AKE
Outcome
Direction not reportedProtection against peroxide-UV damage
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
It was also evaluated that the formulation was protective against H₂O₂-UV-based damage, showed antioxidant activity and collagenase inhibitory activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Additionally, the protective effect of its formulation against H₂O₂-UV-induced skin damage was evaluated at both the cellular and DNA levels.
Report a problemFND-4292705406
05LabIn vitro (cell-free)Activity measurement
In laboratory tests, the Syn‑Ake nanoemulsion formulation showed antioxidant activity.
In plain wordsIn lab tests, the Syn‑Ake nanoemulsion formulation showed antioxidant activity.
Peptide
SYN-AKE
Outcome
Direction not reportedAntioxidant activity
Study
n: not reported in source
Outcome group
Oxidative stress · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
It was also evaluated that the formulation was protective against H₂O₂-UV-based damage, showed antioxidant activity and collagenase inhibitory activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Finally, the antioxidant activity and the collagenase inhibitory activity of the formulation was evaluated.
Report a problemFND-4292705407
06LabIn vitro (cell-free)Activity measurement
In laboratory tests, the Syn‑Ake nanoemulsion formulation inhibited collagenase activity.
In plain wordsIn lab tests, the Syn‑Ake nanoemulsion formulation inhibited collagenase activity.
Peptide
SYN-AKE
Outcome
DecreaseCollagenase inhibition
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
It was also evaluated that the formulation was protective against H₂O₂-UV-based damage, showed antioxidant activity and collagenase inhibitory activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Finally, the antioxidant activity and the collagenase inhibitory activity of the formulation was evaluated.
Report a problemFND-4292705408

Studies that did not test the peptide alone2

In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking SYN-AKE.

07LabNot a test of SYN-AKE aloneIn vitro (cell-free)Other
In formulation tests, researchers identified the most stable Syn‑Ake nanoemulsion among formulations produced with different procedures.
In plain wordsIn lab tests, researchers identified the most stable Syn‑Ake nanoemulsion among formulations produced with different procedures.
Peptide
SYN-AKE
Outcome
Direction not reportedNanoemulsion stability
Study
n: not reported in source
Outcome group
Formulation, delivery and stability · Pharmacology
Source sentences
Summary
The most stable formulation was determined among the formulations developed with different production procedures.
1 context sentence(design, population, supporting numbers)
Summary · context
Then, nanoemulsion formulations of the peptide were produced using ultrasonic homogenization method and stability and characterization studies were conducted.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4292705402
08Computer modelNot a test of SYN-AKE aloneIn silicoMechanism
Computer analyses predicted strong Syn‑Ake interactions with p-38 MAPK and PI3K-AKT signalling pathways, stromelysins and gelatinases.
In plain wordsComputer analyses predicted strong Syn‑Ake interactions with the reported signalling pathways and enzymes.
Peptide
SYN-AKE
Outcome
Not applicablePredicted target interactions
Study
n: not reported in source
Outcome group
Receptor activity and mechanism · Skin and wound
Source sentences
Summary
Our findings showed that the peptide strongly interacted with p-38 MAPK and PI3K-AKT signalling pathways, as well as stromelysins and gelatinases.
1 context sentence(design, population, supporting numbers)
Summary · context
In this context, the anti-aging activity of Syn-Ake peptide was evaluated by molecular docking and MD simulation.
In this study, SYN-AKE was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SYN-AKE.
Report a problemFND-4292705401

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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