PepBank has 1 palmitoyl hexapeptide-12 study with results. It gave palmitoyl hexapeptide-12, with 6 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.
Searches 6 results and 2 papers. Newer studies from Europe PMC
Identifiers, parent molecule, targets and development stage, from curated data.
This record covers N-palmitoyl-VGVAPG. The retired name palmitoyl oligopeptide can also refer to palmitoyl tripeptide-1. The alternative APGVGV sequence is outside this record's defined identity.
No molecular target is recorded for this peptide.
Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.
6 amino acids · 1 modification
No sequence is listed for the parent, so no alignment is shown.CIR defines Pal-VGVAPG as the N-terminal palmitoyl derivative of hexapeptide-12 (VGVAPG), an elastin peptide. No unique protein range is assigned.
Some values cannot be calculated. A modification changes this value and is not modeled here (for example a lipid, metal or linker).
@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses
No charge curve
A modification changes this value and is not modeled here (for example a lipid, metal or linker).
6 residues. Each residue counts in one class; F and W count as aromatic.
No 3D structure
No experimental structure (PDB) and no UniProt entry for an AlphaFold model are listed for this peptide. Synthetic peptides often have neither. The sequence view above is the reference.
Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).
SMILES fromPubChem CID 10212452(opens in a new tab)
CCCCCCCCCCCCCCCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)OPeople first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.
PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.
Counts are exact and come from studies that gave the peptide.
Studies by year
1 of 2 studies has results (50%), published 2025. Top row: every study. Bottom row: studies with results about Palmitoyl hexapeptide-12, by class. The rows use different scales.
Studies2 in all, 2025 to 2026
Studies with results1 in all, 2025
Retracted studies are left out. A study with results in two classes counts in both.
AI wrote and checked these results. AI can make mistakes, so check important results against the source.
Registered trials that test the peptide, with phase, status and dates. A dot marks trials with posted results.
0 trials match. Highest phase first. Data from ClinicalTrials.gov.
No trial matches these filters.
Studies on this peptide. Some have results. The others have none yet.
2 studies match. Retracted studies are left out.
Showing 1 of 2 studiesquery qry_8dcb44f53e0edcfd3330e8b4
1 study
Ex vivo tissue · 2025
Ligorio et al. 2025ACS applied bio materialscited by 6
PMID 39964201PMC11920943DOI 10.1021/acsabm.4c01816PUB-39964201
These studies name Palmitoyl hexapeptide-12 but give no result for it (for example, the results concern another peptide in the study).
PubMed tag: none · 2026
Bjerke et al. 2026Current research in toxicology
PMID 41953401PMC13054063DOI 10.1016/j.crtox.2026.100291PUB-41953401
Page 1 of 1
Ligorio C · ACS applied bio materials · 2025
Ex vivo tissue · 6 results
Approval and sport status, and the safety outcomes reported in study results. Laws and labels change, so check the regulator for the current status.
| Jurisdiction | Body | Status | As of | Source |
|---|---|---|---|---|
| US | FDA | FDA lists UNII HO4ZT5S86C as an ingredient substance. UNII availability does not imply regulatory review or approval. Medicinal approval was not established. | 27 Oct 2026 | precision.fda.gov (opens in a new tab) |
| EU | EMA | No medicinal marketing authorisation was established by the exact-name agency search. The reported CosIng entry concerns a cosmetic ingredient. | 27 Oct 2026 | Not recorded |
| Sport | WADA | Status unknown The 2026 list does not name this ingredient. | 2026 List | wada-ama.org (opens in a new tab) |
| European Union | Note | INCI: PALMITOYL HEXAPEPTIDE-12. CosIng reference 85666. Secondary ingredient dictionaries report this entry. The official page did not return the ingredient detail during this check. An inventory entry is not a medicinal approval. | 27 Oct 2026 | specialchem.com (opens in a new tab) |
| Other national jurisdictions | Note | Targeted FDA, EMA, Australian and Canadian agency searches did not establish medicinal approval. This is not an exhaustive national-register assessment. | 27 Oct 2026 | Not recorded |
Reported effects from study results.
No safety results from studies in people
The doses that these studies used. They are not recommendations.
No dose was reported in the study results.
PepBank is a research reference. Talk to a doctor before you use any peptide.
Data version, change history and code for this peptide.
curl -s https://Evidence summary for Palmitoyl hexapeptide-12: counts by class, key results with sources, notices, data version.
In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated
Top outcomes
The 2 outcome groups with the most study results, by evidence class.
Data version 308560. Bar length is the number of results, not the size of an effect.
Evidence matrix
Study results by outcome and evidence class. Arrows show how the measured outcome moved, not whether the change is good.
| Outcome group | Human | Animal | Lab | Computer model | Total |
|---|---|---|---|---|---|
| Skin and hairSkin and wound | No results | No results | Lab: 4 results from 1 study: 2 increase, 2 not reported. Strongest design: Ex vivo tissue | No results | 4 |
| PharmacokineticsSkin and wound | No results | No results | Lab: 2 results from 1 study: 2 not reported. Strongest design: Ex vivo tissue | No results | 2 |
2 outcome groups shown of 2 · 6 study results
Data version 308560. Shade grows with the number of results. Every cell shows the exact count.