Peptides / Skin and hair

Modified form · 6 amino acids · 737 Da

Palmitoyl hexapeptide-12

Palmitoyl hexapeptide-12 is a palmitoylated cosmetic peptide used in skin care, not an approved drug. On its own, it has been tested only in lab studies on human skin tissue, mostly on how it enters skin and on the skin barrier. PepBank shows 6 results on palmitoyl hexapeptide-12 from animal and lab studies. No study in people has reported results yet. Data as of 2026-10-30.

Also known as palmitoyl hexapeptide 12, palmitoyl-VGVAPG, palmitoyl oligopeptide, Pal-Val-Gly-Val-Ala-Pro-Gly

6 amino acids, from first to lastVGVAPG

Evidence level: Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.

Results in people

0% of 6 results

Results in animals

0% of 6 results

Results in lab cells

100% of 6 results

From computer models

0% of 6 results

Overview

Palmitoyl hexapeptide-12 at a glance

What it is	Modified form, 6 amino acids
Approval	Regulatory status not recorded
In sport	Status unknown
Studies	1 study with results. It gave palmitoyl hexapeptide-12, with 6 results. 6 in lab cells
Clinical trials	None registered
Community use	Skin conditioning in cosmetic products

The science

What is palmitoyl hexapeptide-12?

A palmitoylated cosmetic peptide used as a skin-conditioning ingredient.

Amino acids in one chain

Palmitoyl hexapeptide-12 structure and chemistry

The key facts about the molecule. Long codes are in the closed section below.

Sequence, 6 amino acidsFrom the first amino acid to the last

V1GVAP5G

Darker means more water-repelling+ and − show charge in the bodyOutlined: changed amino acid

Structure

Palmitoyl hexapeptide-12 is a modified form of 6 amino acids, with no ring, 1 changed amino acid.

Formula

C₃₈H₆₈N₆O₈

Molecular weight

737 g/mol

CAS number

171263-26-6

Development

Highest phase: unknown.

Identifiers

PubChem 10212452, UNII HO4ZT5S86C

Full sequence, SMILES and InChIKey

Three-letter sequence
Val-Gly-Val-Ala-Pro-Gly

InChIKey
JFSQSDAOQLNSQI-DTBJPNGVSA-N

SMILES
CCCCCCCCCCCCCCCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O

See charge, composition and 3D structure on the Scientific page

The evidence

What palmitoyl hexapeptide-12 studies show

Results grouped by what the studies measured. Each card shows where its results come from.

Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.

Skin, hair and wounds

4 results · 4 lab

In lab tests with human skin, palmitoyl hexapeptide-12 formed a gel using ions already present. ACS applied bio materials, 2025

Key palmitoyl hexapeptide-12 studies

Studies in people come first, then studies in animals and in the lab.

Lab cells
Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits
Ligorio et al. 2025 · ACS applied bio materials · cited by 6
6 results

1 Palmitoyl hexapeptide-12 study

Palmitoyl hexapeptide-12 clinical trials

ClinicalTrials.gov lists no trial of palmitoyl hexapeptide-12. A trial under another name may exist.

Status and safety

Is palmitoyl hexapeptide-12 approved?

FDA

United States

Status unknown

Status unknown.

EMA

European Union

Status unknown

Status unknown.

WADA

Sport

Not recorded

Status unknown.

Regulatory status not recorded. Status unknown.

Laws and labels change, so check the regulator for the current status.

Palmitoyl hexapeptide-12 side effects and safety

PepBank has no safety result from studies of palmitoyl hexapeptide-12 yet. That does not mean palmitoyl hexapeptide-12 is safe.

From the community

How people use it

What people report online. It comes from forums and guides, not from studies.

Community-reported. Not tested in trials.

The CIR safety assessment reports cosmetic product use of palmitoyl hexapeptide-12. This use report does not establish isolated clinical efficacy.

Reported routines and cautions

What people use it for

Skin conditioning in cosmetic productsS1

Reported regimens

Regimens that community sources report for Palmitoyl hexapeptide-12. Community-reported, not tested in trials.
Context	Route	Amount	How often	How long	Agreement	Sources
Skin conditioning in cosmetic products	Not stated	Not stated	Not stated	Not stated	Single CIR assessment, reproduced by EPA. The EPA record is not an independent second report.	S1

Community sources

S1EPA record of CIR cosmetic peptide safety assessment (opens in a new tab)hero.epa.gov

Gaps

The abstract does not give a product-specific dose, route, frequency or duration. No safe individual regimen is established.

Questions and more

Ask a question about palmitoyl hexapeptide-12

The answer links to every study it uses.

What does the evidence say about palmitoyl hexapeptide-12?Is palmitoyl hexapeptide-12 tested in people?Compare with Difelikefalin Compare with Argireline (acetyl hexapeptide-8)

Sources

Database: PepBank data for palmitoyl hexapeptide-12 (data version 308560)
Regulator: FDA status record
Regulator: WADA status record
Community: community sources (forums and guides), as summarized in the PepBank community file

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Ask your AI about palmitoyl hexapeptide-12

Curo is a peptide shop. PepBank and Curo have the same owner. See the Curo catalog (opens in a new tab).

Palmitoyl hexapeptide-12

Also known as palmitoyl hexapeptide 12, palmitoyl-VGVAPG, palmitoyl oligopeptide, Pal-Val-Gly-Val-Ala-Pro-Gly

What it is

Modified form, 6 amino acids

Approval

Regulatory status not recorded

In sport

Status unknown

Studies

1 study with results. It gave palmitoyl hexapeptide-12, with 6 results.
6 in lab cells

Clinical trials

None registered

Community use

Skin conditioning in cosmetic products

Context

Route

Amount

How often

How long

Agreement

Sources

Skin conditioning in cosmetic products

Not stated

Single CIR assessment, reproduced by EPA. The EPA record is not an independent second report.

Palmitoyl hexapeptide-12

Palmitoyl hexapeptide-12 at a glance

What is palmitoyl hexapeptide-12?

Palmitoyl hexapeptide-12 structure and chemistry