Indexing hint: Randomized controlled trial · 2023
Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.
Lincoff et al. 2023The New England journal of medicinecited by 2,458
PMID 37952131DOI 10.1056/nejmoa2307563PUB-37952131
Trial · Interventional
RecruitingNot applicableRegistry dataShort name Re-CHARM
United Kingdom
1 trial · 1 ongoing
Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.
Traditional diabetes therapies focus on improving blood sugar control. However, many studies show that this may not be enough. New treatments focusing on weight loss have heralded better results. One of these treatments is Semaglutide and the investigators wish to examine its effects further in this study. The investigators propose to investigate what happens to the fat inside the heart and the leg muscles.
Placebo comparator
Semaglutide administration plus dietary counselling and physical activity encouragement
Semaglutide administration plus dietary counselling and physical activity encouragement
Active comparator
Semaglutide and supervised training program
Semaglutide administration plus a personalised and supervised program of resistance and endurance training
Outcomes the sponsor listed as primary.
1H-magnetic resonance spectroscopy
Time frame · From enrollment to the end of treatment at the end of 12 weeks
Non-invasive proton magnetic resonance spectroscopy (1H MRS) for assessment to determine the total intramyocellular fat
Intramyocellular lipid pool compartments
Time frame · From enrollment to the end of treatment at the end of 12 weeks
Intramyocellular Lipid pool compartments examined with non-invasive proton magnetic resonance spectroscopy (1H MRS) and turnover examined with stable isotopes
Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.
No results are posted for this trial.
A trial that is still running, or that stopped early, may post results later.
Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works
Studies that cite this trial.
4 studies on this page
Indexing hint: Randomized controlled trial · 2023
Lincoff et al. 2023The New England journal of medicinecited by 2,458
PMID 37952131DOI 10.1056/nejmoa2307563PUB-37952131
Indexing hint: Randomized controlled trial · 2021
Wilding et al. 2021The New England journal of medicinecited by 3,862
PMID 33567185DOI 10.1056/nejmoa2032183PUB-33567185
Indexing hint: Randomized controlled trial · 2017
Blundell et al. 2017Diabetes, obesity & metabolismcited by 539
PMID 28266779PMC5573908DOI 10.1111/dom.12932PUB-28266779
Indexing hint: Randomized controlled trial · 2016
Marso et al. 2016The New England journal of medicinecited by 5,002
PMID 27633186DOI 10.1056/nejmoa1607141PUB-27633186
Who could join, as posted.
PepBank is a research reference. Talk to a doctor before you use any peptide.
In PepBank now:147 peptides, 6 blends and 13 other compounds97,577 study results from 17,383 studies8,473 clinical trialsUpdated