A Study to Investigate the Effect of MEDI0382 on Hepatic Glycogen Metabolism in Overweight and Obese Subjects With Type 2 Diabetes Mellitus.

Inclusion Criteria: * Body mass index (BMI) ≥ 27 and ≤ 40 kg/m2 (inclusive) at screening * Glycated haemoglobin (HbA1c) ≤ 8.0% at screening * Diagnosed with T2DM with glucose control managed with metformin monotherapy where no significant dose change (increase or decrease ≥ 500 mg/day) has occurred in the 3 months prior to screening Exclusion criteria: * Any subject who has received another investigational product as part of a clinical study or a GLP-1 analogue-containing preparation within the last 30 days or 5 half-lives of the drug (whichever is longer) at the time of screening * Any subject who has received any of the following medications prior to the start of the study: * Herbal preparations or drugs licensed for control of body weight or appetite (eg, orlistat, bupropion naltrexone, phentermine-topiramate, phentermine, lorcaserin) * Opiates, domperidone, metoclopramide or other drugs known to alter gastric emptying * Glucagon * Warfarin * Any contraindication to magnetic resonance imaging/MRS scanning including claustrophobia or dislike of confined spaces * Symptoms of acutely decompensated blood glucose control (eg, thirst, polyuria, weight loss), a history of type 1 diabetes mellitus (T1DM) or diabetic ketoacidosis, or if the subject has been treated with daily SC insulin within 90 days prior to screening * Recurrent unexplained hypoglycaemic episodes (defined as glucose \< 3.0 mmol/L or \< 54 mg/dL on more than 2 occasions in 6 months prior to screening) * Significant inflammatory bowel disease, gastroparesis, or other severe disease or surgery affecting the upper GI tract (including weightreducing surgery and procedures) which may affect gastric emptying or could affect the interpretation of safety and tolerability data * Acute or chronic pancreatitis * Significant hepatic disease (except for NASH or nonalcoholic fatty liver disease without portal hypertension or cirrhosis) and/or subjects with any of the following results at screening: * Aspartate transaminase (AST) ≥ 3 × upper limit of normal (ULN) * Alanine transaminase (ALT) ≥ 3 × ULN * Total bilirubin ≥ 2 × ULN * Impaired renal function defined as estimated glomerular filtration rate (eGFR) \< 30 mL/minute/1.73m2 at screening (glomerular filtration rate estimated according to Modification of Diet in Renal Disease (MDRD) using MDRD Study Equation IDMS-traceable (International System of Units \[SI\] units) * Poorly controlled hypertension defined as: * Systolic blood pressure (BP) \> 180 mm Hg * Diastolic BP \> 105 mm Hg After 10 minutes of supine rest and confirmed by repeated measurement at screening. * Unstable angina pectoris, myocardial infarction, transient ischemic attack or stroke within 3 months prior to screening, or subjects who have undergone percutaneous coronary intervention or a coronary artery bypass graft within the past 6 months or who are due to undergo these procedures at the time of screening * Severe congestive heart failure (New York Heart Association Class III or IV) * Basal calcitonin level \> 50 ng/L at screening or history/family history of medullary thyroid carcinoma or multiple endocrine neoplasia * History of neoplastic disease within 5 years prior to screening, except for adequately treated basal cell, squamous cell skin cancer, or in situ cervical cancer * Any positive results for serum hepatitis B surface antigen (HBsAg), hepatitis C antibody and human immunodeficiency virus (HIV) antibody * Substance dependence or history of alcohol abuse and/or excess alcohol intake (defined as \> 21 units per week for a male subject, and \>14 units per week for a female subject). Subjects must have a negative alcohol test result at screening and prior to randomisation.