Effect of Exenatide on 24h-UAER in Patients With Diabetic Nephropathy

Inclusion Criteria: 1. Provision of informed consent prior to any study specific procedures. 2. Diagnosed with type 2 diabetes with HbA1c ≥ 7.0% and ≤ 11.0% at screening (the result is valid for seven days). 3. Men and women (non-pregnant and using a medically approved birth-control method) aged from 18 to 80 at screening. 4. Body mass index (BMI) ≥18 and ≤35 kg/m2. 5. Blood Pressure (BP) ≥ 90/60mmHg and ≤160/100mmHg. 6.24h urinary albumin excretion rate (UAE) \>0.3g/24h after 3 months treatment with several hypoglycemic agents (sulphonylureas, metformin, AG-inhibitor, meglitinides or insulin), ACEI/ARB and salt restriction(the result is valid for seven days). 7.eGFR \>30ml/min(the result is valid for seven days). Exclusion Criteria: 1．Women who are pregnant, intending to become pregnant during the study period, currently lactating females, or women of child-bearing potential not using highly effective, medically approved birth control methods. 2\. Diagnosis or history of: 1. Type 1 diabetes mellitus, diabetes resulting from pancreatic injury or secondary forms of diabetes, eg, acromegaly or Cushing's syndrome. 2. Acute metabolic diabetic complications such as ketoacidosis or hyperosmolar coma within the past 6 months. 3\. Previous treatment with any Thiazolidinediones (TZDs), dipeptidyl peptidase-4 (DPP4) inhibitor or GLP-1 receptor agonists within the past 3 months. 4\. History of hypersensitivity reaction (e.g., anaphylaxis, angioedema, exfoliative skin conditions) to exenatide. 5\. Blood amylase and/or lipase \> 2 times the upper limit of the normal (ULN) laboratory range. 6\. Hyperkalemia (K+\>5.5mmol/L). 7\. eGFR \<30ml/min/1.73m2. 8\. Patients without diabetic retinopathy. 9\. Triglycerides (fasting) \> 4.5 mmol/L (400 mg/dL) at screening or within 4 weeks prior to screening (by local laboratory). 10\. Patients with clinically apparent liver disease characterized by ALT or AST \> 3ULN confirmed on two consecutive measurements (by local laboratory) within 4 weeks prior to screening period. 11\. Significant cardiovascular history within the past 3 months prior to screening defined as: myocardial infarction, coronary angioplasty or bypass graft(s), valvular disease or repair, unstable angina pectoris, transient ischemic attack, or cerebrovascular accident. 12\. Congestive heart failure defined as New York Heart Association (NYHA) class III or IV. 13\. History of chronic pancreatitis or idiopathic acute pancreatitis. 14\. History of medullary thyroid carcinoma.