Glucagon, incretin, glucose, NEFA, insulin and C-peptide response during meal test
Time frame · Baseline (week 0), week 12, week 14, week 26
Insulin sensitivity (Si), acute insulin and C-peptide response to intravenous glucose (AIRg, ACRg), glucose clearance (Kg), glucose effectiveness (Sg) and hepatic extraction of insulin (HEXi)
Time frame · Baseline (week 0), week 12, week 14, week 26
Registry description
Insulin sensitivity (Si), acute insulin and C-peptide response to intravenous glucose (AIRg, ACRg), glucose clearance (Kg), glucose effectiveness (Sg) and hepatic extraction of insulin (HEXi) derived from a standard frequent sampling intravenous glucose tolerance test (FSIGT, Minimal model)
CRP, TNF-alfa and IL-6 in plasma and gene expression of IL6 and TNF-alfa in subcutaneous fat
Time frame · Baseline (week 0), week 12, week 14, week 26
Non esterified fatty acids (NEFA)
Time frame · Baseline (week 0), week 12, week 14, week 26
Registry description
NEFA during FSIGT by use of NEFA minimal model
Heart rate variability (HRV)
Time frame · Baseline (week 0), week 12, week 14, week 26
Registry description
HRV i.e. SDNN (standard deviation of all normal RR interval) assessed during HOLTER monitoring
Maximal velocity of the myocardium in systole (s´) and in diastole (e´)
Time frame · Baseline (week 0), week 12, week 14, week 26
Registry description
Maximal velocity of the myocardium in systole (s´) and in diastole (e´) during the dobutamine stress test
Changes in exercise tolerance test variables: Total exercise duration (sec), time to limiting angina (sec) and time to 1 mm ST-segment depression (sec)
Time frame · Baseline (week 0), week 12, week 14, week 26
Registry description
Changes in exercise tolerance test variables: Total exercise duration (sec), time to limiting angina (sec) and time to 1 mm ST-segment depression (sec)
ST-depression and ectopic activity
Time frame · Baseline (week 0), week 12, week 14, week 26
Registry description
ST-depression and ectopic activity assessed during 24h HOLTER monitoring
Diurnal blood pressure
Time frame · Baseline (week 0), week 12, week 14, week 26
Diastolic heart function (E/E*)
Time frame · Baseline (week 0), week 12, week 14, week 26
Registry description
Diastolic heart function (E/E\*) in rest and during stress