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Trial · Interventional

CompletedNot applicableRegistry data

Oral Glutathione Supplementation on the Levels of Blood Glutathione

NCTNCT01044277 (opens ClinicalTrials.gov in a new tab)Other idPSHCI 09-059
Open at ClinicalTrials.govAsk about this trial

Overview

Status
Completed
Phase
Not applicable
Enrollment
61 participants (actual)
Sponsor
Milton S. Hershey Medical Center · Other
Design
Randomized · Double masking
Countries
1 country

United States

Start
Feb 2010
Primary completion
Sept 2011
Completion
Oct 2014
First posted
7 Jan 2010 (estimated)
Last update posted
6 Sept 2022
Conditions
Healthy Adults

Timeline

1 trial · 1 completed

  • Completed
  • Ongoing
  • Not yet recruiting
  • Stopped
  • Estimated dates (est.)
  • Results posted
201020112012201320142015
  1. N/A

    Oral Glutathione Supplementation on the Levels of Blood Glutathione

    NCT01044277

    Feb 2010 to Oct 2014

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

This trial is designed to provide evidence of the efficacy of glutathione supplementation and health(GSH) and includes the assessment of both short term and long term effects. Based on previous laboratory animal studies and clinical data, the investigators anticipate that the effects of oral GSH supplementation will be progressive and cumulative. The study will also allow for the evaluation of effects of withdrawal of the supplement on the outcome variables.

Interventions

  • Glutathione supplementationDrug
  • Gluthathione peroxidasesDrug
  • PlaceboOther

Arms3

  • Experimental

    Group A

    Glutathione supplementation-Double-Blind - GSH 500 mg/GSH 125 mg/Placebo Other name Gluthathione peroxidases

  • Experimental

    Group B

    Glutathione supplementation-Double-Blind - GSH 500 mg/GSH 125 mg/Placebo Other name Gluthathione peroxidases

  • Placebo comparator

    Group C

    Placebo-Double-Blind - GSH 500 mg/GSH 125 mg/Placebo

Primary outcomes1

Outcomes the sponsor listed as primary.

  1. Evaluation of the effect of glutathione on key biomarkers

    Time frame · 6 to 7 months

    Registry description

    Blood glutathione status

Secondary outcomes(1)

  1. Evaluations will be carried out to expand the above comparison by including adjustments for potential prognostic factors.

    Time frame · 6 to 7 months

    Registry description

    Biomarkers of oxidative stress and immune function

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

No results are posted for this trial.

Completed trials do not always post results.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies1

Studies that cite this trial.

Studies with results

1 study on this page

Indexing hint: Randomized controlled trial · 2015

11 results

Randomized controlled trial of oral glutathione supplementation on body stores of glutathione.

Jr et al. 2015European journal of nutritioncited by 80

PMID 24791752DOI 10.1007/s00394-014-0706-zPUB-24791752

Full text at the publisher11 results
Publisher pageSee results (11)

Eligibility

Who could join, as posted.

Sex
All
Age
from 30 Years up to 79 Years
Healthy volunteers
Accepted
Inclusion and exclusion criteria, as posted
Inclusion Criteria: * Healthy male and females between the ages of 30 and 79 years of age * Not taking glutathione as a dietary supplement * Not taking high dose antioxidant supplement prior to 1 month * Baseline blood glutathione level of \< 1 mmol/L Exclusion Criteria: * History or evidence of disease including cancer, diabetes, heart disease * Subjects who smoke

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