Skip to content

Study · Other design · 2014

4 results

The role of kisspeptin in reproduction

Comninos A

Imperial College London1 Jan 2014

DOI10.25560/33252 (opens in a new tab)PepBankPUB-97999408
Source linkSource pageAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 3 results from people.

  1. 01HumanOther designEfficacy outcome

    In healthy men and women, the gonadotrophin response to kisspeptin‑10 differed by sex.

    In plain wordsIn healthy men and women, the hormone response to kisspeptin‑10 differed between men and women.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableSex difference in gonadotrophin response to kisspeptin-10
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By investigating the effects of the kisspeptin-10 peptide in healthy men and women, I uncover a sexual dimorphism in gonadotrophin response to kisspeptin-10
  2. 02HumanOther designEfficacy outcome

    In healthy humans, kisspeptin‑10 was less potent than kisspeptin-54 for gonadotrophin response.

    In plain wordsIn healthy people, kisspeptin‑10 was less potent than kisspeptin-54 in raising reproductive hormones.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePotency of kisspeptin-10 versus kisspeptin-54
    Study

    n: not reported in source

    Comparator
    Kisspeptin-54
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    a greater potency of kisspeptin-54 over kisspeptin-10 in humans
  3. 03HumanOther designEfficacy outcome

    In humans, kisspeptin‑54 was more potent than kisspeptin-10.

    In plain wordsIn people, kisspeptin‑54 was more potent than kisspeptin-10.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreasePotency versus kisspeptin-10
    Study

    n: not reported in source

    Comparator
    Kisspeptin-10
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By investigating the effects of the kisspeptin-10 peptide in healthy men and women, I uncover a sexual dimorphism in gonadotrophin response to kisspeptin-10 as well as a greater potency of kisspeptin-54 over kisspeptin-10 in humans.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In adult mice, kisspeptin administration markedly decreased neuronal activity in the amygdala on manganese-enhanced MRI.

    In plain wordsIn mice, kisspeptin lowered activity of nerve cells in the amygdala, a brain region.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseAmygdala neuronal activity on manganese-enhanced MRI
    Study

    mousen: not reported in source

    Adult mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Using manganese-enhanced MRI to detect neuronal activity, I demonstrate marked decreases in neuronal activity in the amygdala of adult mice after kisspeptin administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    10 Oct 2026, 09:43 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.