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Study · Other design · 2012

3 results

Investigation of the novel hormone kisspeptin in disorders of reproduction

Nijher GMK

Imperial College London1 Jan 2012

DOI10.25560/10542 (opens in a new tab)PepBankPUB-93767597
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanOther designEfficacy outcome

    In women with infertility from hypothalamic amenorrhoea, acute kisspeptin‑54 administration stimulated reproductive hormones.

    In plain wordsIn women with hypothalamic amenorrhoea, one dose of kisspeptin‑54 raised reproductive hormone levels.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseReproductive hormones after acute administration
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    acute administration of kisspeptin to women with hypothalamic amenorrhoea results in stimulation of reproductive hormones
    1 context sentence
    Summary · context
    In this study I have examined the effects of acute and chronic administration of kisspeptin-54 on women with infertility due to hypothalamic amenorrhoea.
  2. 02HumanOther designEfficacy outcome

    In women with hypothalamic amenorrhoea, twice-daily kisspeptin‑54 at 6.4 nmol/kg for two weeks led to tachyphylaxis.

    In plain wordsIn women with hypothalamic amenorrhoea, twice-daily kisspeptin‑54 for two weeks lost its effect over time.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    DecreaseResponse to twice-daily dosing for two weeks
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    6.4 nmol/kg · injection · two weeksAs given in this study (human).

    Source sentences

    Summary
    chronic administration for two weeks of twice daily injections of kisspeptin-54 at a dose of 6.4 nmol/kg, results in tachyphylaxis.
    1 context sentence
    Summary · context
    In this study I have examined the effects of acute and chronic administration of kisspeptin-54 on women with infertility due to hypothalamic amenorrhoea.
  3. 03HumanOther designEfficacy outcome

    Twice-weekly kisspeptin‑54 administration gave sustained stimulation of gonadotrophin release.

    In plain wordsKisspeptin‑54 given twice a week kept gonadotrophin release raised.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseGonadotrophin release with twice-weekly dosing
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    I have also determined that a dosing regime of twice weekly administration of kisspeptin-54 results in sustained stimulation of gonadotrophin release.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    10 Oct 2026, 09:43 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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