In a meta-analysis of populations with and without diabetes, semaglutide was associated with significantly greater adjusted weight-reduction magnitude than liraglutide (beta +1.67; P<0.001).
In plain wordsIn a review of people with and without diabetes, semaglutide was linked to greater adjusted weight reduction than liraglutide.
- Peptide
- Semaglutide
- Outcome
- IncreaseMagnitude of adjusted weight reduction versus liraglutide
- Study
n: not reported in source
- Comparator
- Liraglutide
- Outcome group
- Body weight · Metabolic and weight
- Studied dose
- Dose not stated
Measurements
- Beta
- 1.67
- semaglutide versus liraglutide; P<0.001
Source sentences
Semaglutide produced significantly greater reductions than liraglutide after adjustment (β = + 1.67, p < 0.001), while baseline BMI was inversely associated with percent weight change (β = + 0.46, p < 0.001).
3 context sentences(design, population, supporting numbers)
This study represents a subgroup analysis of a large-scale meta-analysis including clinical trials, observational and case-control studies published from 2010 to 2025 reporting long-term weight outcomes for GLP-1 agents.
Outcomes were evaluated across mixed, intention-to-treat (ITT), and treatment-adherent populations and stratified by diabetes status.
Mixed-effects meta-regression was performed to evaluate independent predictors of weight loss.