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Study · Not a test of the peptide alone · 2026

12 results

Association Between Glucagon-Like Peptide-1 Receptor Agonists and Suicidality: A Systematic Review.

Chan TH, Cosler LE, Gionfriddo MR, Leppien EE, Sommers EJ, Lussier ME

Diabetes, obesity & metabolism18 May 2026Cited by 1 (Europe PMC)

PMID42150748 (opens in a new tab)PMCIDPMC13341386 (opens in a new tab)DOI10.1111/dom.70878 (opens in a new tab)PepBankPUB-42150748
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone12

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01HumanNot a test of Liraglutide aloneSystematic reviewOther

    In a systematic review of adults using GLP-1 drugs, some pharmacovigilance and cohort studies identified a positive association between semaglutide or liraglutide use and suicidal ideation.

    In plain wordsIn some adult pharmacovigilance and cohort studies, semaglutide or liraglutide use was linked to more suicidal thoughts.

    Peptide
    Liraglutide
    Outcome
    IncreaseSuicidal ideation
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…
    3 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  2. 02HumanNot a test of Semaglutide aloneSystematic reviewOther

    In a systematic review of adults using GLP-1 drugs, some pharmacovigilance and cohort studies identified a positive association between semaglutide or liraglutide use and suicidal ideation.

    In plain wordsIn some adult pharmacovigilance and cohort studies, semaglutide or liraglutide use was linked to more suicidal thoughts.

    Peptide
    Semaglutide
    Outcome
    IncreaseSuicidal ideation
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…
    3 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  3. 03HumanNot a test of Liraglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, some case reports suggested a temporal relationship between pooled GLP-1 receptor agonist use and suicidal ideation.

    In plain wordsIn some adult case reports, pooled GLP-1 drug use was temporally linked to suicidal thoughts.

    Peptide
    Liraglutide
    Outcome
    Direction not reportedTemporal relationship with suicidal ideation in case reports
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Some case reports suggested a temporal relationship between GLP-1 RA use and suicidal ideation.
    4 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.
    Summary · context
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  4. 04HumanNot a test of Semaglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, some case reports suggested a temporal relationship between pooled GLP-1 receptor agonist use and suicidal ideation.

    In plain wordsIn some adult case reports, pooled GLP-1 drug use was temporally linked to suicidal thoughts.

    Peptide
    Semaglutide
    Outcome
    Direction not reportedTemporal relationship with suicidal ideation in case reports
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Some case reports suggested a temporal relationship between GLP-1 RA use and suicidal ideation.
    4 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.
    Summary · context
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  5. 05HumanNot a test of Liraglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, cross-sectional and case-control studies identified a negative association between pooled GLP-1 receptor agonists and suicide attempts.

    In plain wordsIn adult observational studies, pooled GLP-1 drugs were linked to fewer suicide attempts.

    Peptide
    Liraglutide
    Outcome
    DecreaseSuicide attempts in cross-sectional and case-control studies
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Cross-sectional studies and case-control studies identified a negative association between GLP-1 RAs and suicide attempts.
    4 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.
    Summary · context
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  6. 06HumanNot a test of Semaglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, cross-sectional and case-control studies identified a negative association between pooled GLP-1 receptor agonists and suicide attempts.

    In plain wordsIn adult observational studies, pooled GLP-1 drugs were linked to fewer suicide attempts.

    Peptide
    Semaglutide
    Outcome
    DecreaseSuicide attempts in cross-sectional and case-control studies
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Cross-sectional studies and case-control studies identified a negative association between GLP-1 RAs and suicide attempts.
    4 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.
    Summary · context
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  7. 07HumanNot a test of Liraglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, some pharmacovigilance and cohort studies reported a negative association between pooled GLP-1 receptor agonists and suicide attempts.

    In plain wordsIn some adult observational studies, pooled GLP-1 drugs were linked to fewer suicide attempts.

    Peptide
    Liraglutide
    Outcome
    DecreaseSuicide attempts in pharmacovigilance and cohort studies
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…
    3 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  8. 08HumanNot a test of Semaglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, some pharmacovigilance and cohort studies reported a negative association between pooled GLP-1 receptor agonists and suicide attempts.

    In plain wordsIn some adult observational studies, pooled GLP-1 drugs were linked to fewer suicide attempts.

    Peptide
    Semaglutide
    Outcome
    DecreaseSuicide attempts in pharmacovigilance and cohort studies
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…
    3 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  9. 09HumanNot a test of Liraglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, some pharmacovigilance and cohort studies reported a negative association between pooled GLP-1 receptor agonists and completed suicide.

    In plain wordsIn some adult observational studies, pooled GLP-1 drugs were linked to fewer deaths by suicide.

    Peptide
    Liraglutide
    Outcome
    DecreaseCompleted suicide in pharmacovigilance and cohort studies
    Study

    n: not reported in source

    Outcome group
    Mortality · Mental health and mood

    Source sentences

    Summary
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…
    3 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  10. 10HumanNot a test of Semaglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, some pharmacovigilance and cohort studies reported a negative association between pooled GLP-1 receptor agonists and completed suicide.

    In plain wordsIn some adult observational studies, pooled GLP-1 drugs were linked to fewer deaths by suicide.

    Peptide
    Semaglutide
    Outcome
    DecreaseCompleted suicide in pharmacovigilance and cohort studies
    Study

    n: not reported in source

    Outcome group
    Mortality · Mental health and mood

    Source sentences

    Summary
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…
    3 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  11. 11HumanNot a test of Liraglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, some pharmacovigilance and cohort studies reported a negative association between pooled GLP-1 receptor agonists and intentional self-harm.

    In plain wordsIn some adult observational studies, pooled GLP-1 drugs were linked to less intentional self-harm.

    Peptide
    Liraglutide
    Outcome
    DecreaseIntentional self-harm in pharmacovigilance and cohort studies
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…
    3 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.

    In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.

  12. 12HumanNot a test of Semaglutide aloneSystematic reviewOther

    In a systematic review of adult observational studies, some pharmacovigilance and cohort studies reported a negative association between pooled GLP-1 receptor agonists and intentional self-harm.

    In plain wordsIn some adult observational studies, pooled GLP-1 drugs were linked to less intentional self-harm.

    Peptide
    Semaglutide
    Outcome
    DecreaseIntentional self-harm in pharmacovigilance and cohort studies
    Study

    n: not reported in source

    Outcome group
    Adverse events · Mental health and mood

    Source sentences

    Summary
    Pharmacovigilance and cohort studies showed more mixed results, with some studies identifying a positive association between semaglutide or liraglutide and suicidal ideation, while others paradoxically reported a negative association with suicidal behaviours (i.e., attempts and intentional self-harm…
    3 context sentences
    Summary · context
    A comprehensive search of MEDLINE, PubMed, EMBASE, CINAHL and PsycINFO was conducted from database inception through December 11, 2025.
    Summary · context
    Observational studies investigating suicidal ideation, suicide attempts or complete suicide among adults using GLP-1 RAs were included.
    Summary · context
    Eligibility screening, data extraction and risk of bias assessments were performed independently and in duplicate, with disagreements resolved by a third reviewer.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:06 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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