Diagnostic Usefulness of Subcutaneous Triptorelin Stimulation Testing in the Evaluation of Central Precocious Puberty in Girls.

Cho MH, Kim J, Shim YS, Lee HS

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme9 Apr 2026

PMID41956123DOI10.1055/a-2844-9524PepBankPUB-41956123

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanObservational studyActivity measurement
In girls evaluated for central precocious puberty, gonadorelin stimulation raised luteinizing hormone to peak levels similar to those after triptorelin.
In plain wordsIn girls with central precocious puberty, gonadorelin raised luteinizing hormone to a peak similar to triptorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreasePeak luteinizing hormone rise after stimulation
Study
n = 219
Comparator
Subcutaneous triptorelin
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Both stimulating agents elicited significant luteinizing hormone level rises in patients with central precocious puberty to similar peak luteinizing hormone levels (13.9±12.8 vs. 12.8±12.1 IU/L).
2 context sentences(design, population, supporting numbers)
Summary · context
Central precocious puberty was diagnosed in 219 girls (130 in the gonadorelin group and 89 in the triptorelin group).
Summary · context
We retrospectively reviewed the medical records of 662 girls aged less than 8 years who were tested for central precocious puberty at the Ajou University Hospital in 2021.
Report a problemFND-4195612301
02HumanObservational studyActivity measurement
In girls with central precocious puberty, luteinizing hormone responses to gonadorelin peaked at 30 minutes, earlier than responses to triptorelin.
In plain wordsIn girls with central precocious puberty, the luteinizing hormone response to gonadorelin peaked at 30 minutes, earlier than with triptorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableTime of maximal luteinizing hormone response
Study
n = 130
Comparator
Subcutaneous triptorelin
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Time to peak LH
30 minutes
gonadorelin
Source sentences
Summary
Gonadorelin responses peaked at 30 minutes, whereas triptorelin responses peaked later, with 31.5% of patients with central precocious puberty showing a maximal luteinizing hormone level at 120 minutes.
2 context sentences(design, population, supporting numbers)
Summary · context
Central precocious puberty was diagnosed in 219 girls (130 in the gonadorelin group and 89 in the triptorelin group).
Summary · context
We retrospectively reviewed the medical records of 662 girls aged less than 8 years who were tested for central precocious puberty at the Ajou University Hospital in 2021.
Report a problemFND-4195612302
03HumanObservational studyOther
In girls with central precocious puberty, all were identified 60 minutes after gonadorelin administration.
In plain wordsIn girls with central precocious puberty, all cases were identified 60 minutes after gonadorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableEarliest diagnostic time point
Study
n = 130
Comparator
Subcutaneous triptorelin
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Time to identify all CPP cases
60 minutes
gonadorelin
Source sentences
Summary
All patients with central precocious puberty were identified 60 minutes after gonadorelin administration
2 context sentences(design, population, supporting numbers)
Summary · context
Central precocious puberty was diagnosed in 219 girls (130 in the gonadorelin group and 89 in the triptorelin group).
Summary · context
We retrospectively reviewed the medical records of 662 girls aged less than 8 years who were tested for central precocious puberty at the Ajou University Hospital in 2021.
Report a problemFND-4195612303
04HumanObservational studyOther
In girls tested for central precocious puberty, single-time-point luteinizing hormone measurements after gonadorelin agreed well with serial sampling, with the best time point at 60 minutes.
In plain wordsIn girls tested for central precocious puberty, one blood sample at 60 minutes after gonadorelin matched serial sampling well.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableConcordance of single-time-point LH with serial sampling
Study
n: not reported in source
Comparator
Serial luteinizing hormone sampling
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Measurements
Best single time point
60 minutes
gonadorelin
Source sentences
Summary
Single-time-point luteinizing hormone measurements showed high concordance with serial sampling, peaking at 60 minutes for gonadorelin and at 120 minutes for triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
We retrospectively reviewed the medical records of 662 girls aged less than 8 years who were tested for central precocious puberty at the Ajou University Hospital in 2021.
Report a problemFND-4195612304

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 2
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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