In people with schizophrenia and antipsychotic-induced weight gain, semaglutide had the highest probability of being most effective for the primary outcome of weight change versus usual care (MD -13.5) in the network meta-analysis.
In plain wordsIn people with schizophrenia and antipsychotic-related weight gain, semaglutide reduced the primary weight-change outcome more than usual care.
- Peptide
- Semaglutide
- Outcome
- DecreaseWeight change
- Study
n: not reported in source
- Comparator
- Usual care
- Analysis
- Primary
- Outcome group
- Body weight · Metabolic and weight
- Studied dose
- Dose not stated
Measurements
- Mean difference
- −13.5
- Semaglutide versus Usual care
Source sentences
Regarding the weight change, the highest three interventions hold the highest probability of being the most effective therapy in weight loss compared to the Usual care group were Semagultide (MD: -13.5 [-17.3, -9.57], followed by Metformin + NutriEx (MD: -6.34, [-9.85, -2.9]), then Nizatidine (MD: -…
1 context sentence(design, population, supporting numbers)
Only randomized placebo-controlled trials were included. We focused on anthropometric measurements and safety profiles. The primary outcome was weight change, while the secondary outcomes included waist-hip ratio, waist circumference, and hip circumference.ResultFifty-five studies were incl…