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Study · Case report or series · n = 1 · 2025

3 results

Acute Duodenal Ulcer Perforation Following Tirzepatide Treatment: A Case Report.

Hayashi M, Hayashi K, Tsujigiwa Y, Uwafuji S, Sato M, Kobayashi Y

Cureus16 Mar 2025

PMID40236372 (opens in a new tab)PMCIDPMC11999657 (opens in a new tab)DOI10.7759/cureus.80671 (opens in a new tab)PepBankPUB-40236372
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Summary

We present the case of a 36-year-old man with a history of type 2 diabetes mellitus (T2DM) and prior plantar necrotizing fasciitis, who initially improved on semaglutide but later experienced weight gain and elevated hemoglobin A1C (HbA1c) levels. After switching to tirzepatide, he developed nausea, epigastric pain, and vomiting. Shortly after increasing the tirzepatide dosage, he presented to the emergency room with severe abdominal pain. Diagnostic imaging revealed an ulcer in the duodenal bulb with free air, indicating acute duodenal ulcer perforation. The patient underwent emergency surgery, and postoperative tests confirmed a Helicobacter pylori infection. He received eradication therapy and was discharged about two months later. This case highlights the potential risk of duodenal perforation associated with tirzepatide, particularly in patients with untreated Helicobacter pylori infection. The patient's worsening gastrointestinal symptoms and perforation after initiating tirzepatide suggest a potential drug-related effect, emphasizing the need for careful monitoring and further research into the mechanisms underlying gastrointestinal complications associated with tirzepatide.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    A 36-year-old man with type 2 diabetes initially improved on semaglutide but later had weight gain and raised HbA1c.

    In plain wordsOne 36-year-old man with diabetes first improved on semaglutide, but later gained weight and had higher HbA1c.

    Peptide
    Semaglutide
    Outcome
    MixedGlycemic and weight response to semaglutide
    Study

    n = 1

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We present the case of a 36-year-old man with a history of type 2 diabetes mellitus (T2DM) and prior plantar necrotizing fasciitis, who initially improved on semaglutide but later experienced weight gain and elevated hemoglobin A1C (HbA1c) levels.
  2. 02HumanCase report or seriesSafety outcome

    A 36-year-old man with type 2 diabetes developed nausea, epigastric pain and vomiting after switching from semaglutide to tirzepatide.

    In plain wordsOne 36-year-old man with diabetes had nausea, stomach pain and vomiting after switching to tirzepatide.

    Peptide
    Tirzepatide
    Outcome
    IncreaseNausea, epigastric pain and vomiting after switch to tirzepatide
    Study

    n = 1

    Outcome group
    Gastrointestinal adverse events · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After switching to tirzepatide, he developed nausea, epigastric pain, and vomiting.
  3. 03HumanCase report or seriesSafety outcome

    A 36-year-old man with type 2 diabetes had an acute duodenal ulcer perforation soon after the tirzepatide dose was increased; H. pylori infection was confirmed.

    In plain wordsOne 36-year-old man with diabetes had a perforated stomach-area ulcer soon after his tirzepatide dose went up; he also had an H. pylori infection.

    Peptide
    Tirzepatide
    Outcome
    IncreaseAcute duodenal ulcer perforation after tirzepatide dose increase
    Study

    n = 1

    Outcome group
    Gastrointestinal adverse events · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Shortly after increasing the tirzepatide dosage, he presented to the emergency room with severe abdominal pain. Diagnostic imaging revealed an ulcer in the duodenal bulb with free air, indicating acute duodenal ulcer perforation.
    1 context sentence
    Summary · context
    The patient underwent emergency surgery, and postoperative tests confirmed a Helicobacter pylori infection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:07 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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