In an unadjusted indirect comparison of phase 3 trials in people with obesity or overweight, tirzepatide 10 mg gave 4% more weight loss than semaglutide 2.4 mg.
In plain wordsIn an indirect comparison of trials, tirzepatide 10 mg led to more weight loss than semaglutide 2.4 mg.
- Peptide
- Tirzepatide
- Outcome
- DecreaseAdditional weight loss versus semaglutide 2.4 mg
- Study
n: not reported in source
- Comparator
- Semaglutide 2.4 mg (indirect comparison)
- Outcome group
- Body weight · Metabolic and weight
- Studied dose
- 10 mgAs given in this study (human).
Measurements
- Additional weight loss
- 4%
- tirzepatide 10 mg vs semaglutide 2.4 mg
Source sentences
Our unadjusted analysis without individual patients' data found relatively higher (4 and 5.4 % additional) weight loss
1 context sentence(design, population, supporting numbers)
Subsequently, we compared the most closely matched trials conducted with semaglutide 2.4 mg and tirzepatide through an adjusted (if baseline imbalance in treatment outcome modifiers present) or unadjusted (in the absence of baseline imbalance) indirect treatment comparison method.