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Study · Animal study (in vivo) · sheep · 2025

2 results

KNDy Neurons and the Control of the Gonadotropic Axis in the Midgestation Fetal Sheep.

Amodei R, Jonker SS, Lazen E, Nestor CC, Estill CT, Roselli CE

Endocrinology1 Mar 2025Cited by 1 (Europe PMC)

PMID40048705 (opens in a new tab)PMCIDPMC12168063 (opens in a new tab)DOI10.1210/endocr/bqaf049 (opens in a new tab)PepBankPUB-40048705
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In midgestation fetal sheep, a bolus of KP-10 elicited robust LH release within 15 minutes.

    In plain wordsIn sheep fetuses, a single dose of KP-10 caused a strong rise in luteinizing hormone within 15 minutes.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH release after KP-10 bolus
    Study

    sheepn: not reported in source

    unanesthetized cannulated midgestation fetal sheep
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    bolus administration of KP-10 (a Kiss receptor agonist) and senktide (NK3 receptor agonist) elicited robust LH release within 15 minutes
    1 context sentence
    Summary · context
    Additionally, unanesthetized cannulated midgestation fetal sheep were used to examine the effects of KNDy peptides on LH secretion and characterize receptor specificity.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 02AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism

    In midgestation fetal sheep, the Kiss receptor antagonist P271 did not block the LH response to KP-10; the result describes the antagonist.

    In plain wordsIn sheep fetuses, a kisspeptin receptor blocker did not stop the rise in luteinizing hormone caused by KP-10.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH response to KP-10 after Kiss receptor antagonist P271
    Study

    sheepn: not reported in source

    unanesthetized cannulated midgestation fetal sheep
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    P271 (Kiss receptor antagonist) did not affect basal LH or block the LH response to KP-10.
    1 context sentence
    Summary · context
    Additionally, unanesthetized cannulated midgestation fetal sheep were used to examine the effects of KNDy peptides on LH secretion and characterize receptor specificity.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:34 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    10 Oct 2026, 09:43 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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