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Study · Observational study · 2025

21 results

Revisional endoscopic sleeve gastroplasty versus semaglutide and tirzepatide for weight recidivism after sleeve gastrectomy.

Bahdi F, Shah S, Dahoud F, Farooq M, Kozan P, Kim S, Sedarat A, Shen N, Thaker A, Kolb JM, Dutson E, Muthusamy VR, Issa D

Clinical obesity5 Feb 2025Cited by 7 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study21

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In patients with weight recidivism after sleeve gastrectomy, tirzepatide gave similar 12-month TBWL to R-ESG (13.2% versus 13.4%).

    In plain wordsAfter sleeve gastrectomy, tirzepatide gave about the same weight loss at 12 months as a repeat endoscopic procedure.

    Outcome
    No significant changeTBWL at 12 months versus R-ESG
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    TBWL
    13.2%
    tirzepatide, 12 months
    TBWL
    13.4%
    R-ESG, 12 months

    Source sentences

    Summary
    tirzepatide achieved similar 12-months TBWL% as R-ESG (13.2% vs. 13.4%, p = .9)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.
  2. 02HumanObservational studyEfficacy outcome

    In patients with weight recidivism after sleeve gastrectomy, tirzepatide gave significantly more 12-month TBWL than semaglutide (13.2% versus 8.1%).

    In plain wordsAfter sleeve gastrectomy, tirzepatide gave more weight loss at 12 months than semaglutide.

    Outcome
    IncreaseTBWL at 12 months versus semaglutide
    Study

    n: not reported in source

    Comparator
    Semaglutide
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    TBWL
    13.2%
    tirzepatide, 12 months
    TBWL
    8.1%
    semaglutide, 12 months

    Source sentences

    Summary
    and significantly more than semaglutide (13.2% vs. 8.1%, p = .04)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.
  3. 03HumanObservational studyEfficacy outcome

    In patients with weight recidivism after sleeve gastrectomy, semaglutide gave significantly less 12-month TBWL than tirzepatide (8.1% versus 13.2%).

    In plain wordsAfter sleeve gastrectomy, semaglutide gave less weight loss at 12 months than tirzepatide.

    Outcome
    DecreaseTBWL at 12 months versus tirzepatide
    Study

    n: not reported in source

    Comparator
    Tirzepatide
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated · 12 monthsAs given in this study (human).

    Measurements

    TBWL
    8.1%
    semaglutide, 12 months
    TBWL
    13.2%
    tirzepatide, 12 months

    Source sentences

    Summary
    and significantly more than semaglutide (13.2% vs. 8.1%, p = .04)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

Studies that did not test the peptide alone18

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 04HumanNot a test of Semaglutide aloneObservational studyEfficacy outcome

    After sleeve gastrectomy, pooled GLP1/GIP-RA (including semaglutide) gave lower 3-month TBWL than R-ESG (4.3% versus 11.2%).

    In plain wordsAfter sleeve gastrectomy, GLP-1 type drugs as a group gave less weight loss at 3 months than a repeat endoscopic procedure.

    Outcome
    DecreaseTBWL at 3 months, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    4.3%
    GLP1/GIP-RA, 3 months
    TBWL
    11.2%
    R-ESG, 3 months

    Source sentences

    Summary
    R-ESG offered higher TBWL% than GLP1/GIP-RA at 3 (11.2% vs. 4.3%, p < .001)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  2. 05HumanNot a test of Semaglutide aloneObservational studyEfficacy outcome

    After sleeve gastrectomy, pooled GLP1/GIP-RA (including semaglutide) gave lower 6-month TBWL than R-ESG (6.8% versus 13.5%).

    In plain wordsAfter sleeve gastrectomy, GLP-1 type drugs as a group gave less weight loss at 6 months than a repeat endoscopic procedure.

    Outcome
    DecreaseTBWL at 6 months, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    6.8%
    GLP1/GIP-RA, 6 months
    TBWL
    13.5%
    R-ESG, 6 months

    Source sentences

    Summary
    6 (13.5% vs. 6.8%, p < .001)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  3. 06HumanNot a test of Semaglutide aloneObservational studyEfficacy outcome

    After sleeve gastrectomy, 12-month TBWL for pooled GLP1/GIP-RA (including semaglutide) was not significantly different from R-ESG (9.2% versus 13.4%).

    In plain wordsAfter sleeve gastrectomy, GLP-1 type drugs as a group did not differ significantly from a repeat endoscopic procedure in weight loss at 12 months.

    Outcome
    No significant changeTBWL at 12 months, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    9.2%
    GLP1/GIP-RA, 12 months
    TBWL
    13.4%
    R-ESG, 12 months

    Source sentences

    Summary
    12 months (13.4% vs. 9.2%, p = .07)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  4. 07HumanNot a test of Semaglutide aloneObservational studySafety outcome

    After sleeve gastrectomy, adverse events did not differ significantly between R-ESG and pooled GLP1/GIP-RA (including semaglutide).

    In plain wordsAfter sleeve gastrectomy, side effects were not clearly different between a repeat endoscopic procedure and GLP-1 type drugs as a group.

    Outcome
    No significant changeAdverse events, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Adverse events · Whole body

    Source sentences

    Summary
    with no significant difference in AEs or change in metabolic parameters
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  5. 08HumanNot a test of Semaglutide aloneObservational studyEfficacy outcome

    After sleeve gastrectomy, change in metabolic parameters did not differ significantly between R-ESG and pooled GLP1/GIP-RA (including semaglutide).

    In plain wordsAfter sleeve gastrectomy, changes in blood measures were not clearly different between a repeat endoscopic procedure and GLP-1 type drugs as a group.

    Outcome
    No significant changeMetabolic parameters, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    with no significant difference in AEs or change in metabolic parameters
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  6. 09HumanNot a test of Semaglutide aloneObservational studyEfficacy outcome

    Pooled GLP1/GIP-RA (including semaglutide) gave lower 3-month TBWL in patients with prior sleeve gastrectomy than in patients with an intact stomach (4.3% versus 5.7%).

    In plain wordsGLP-1 type drugs as a group gave less weight loss at 3 months after sleeve gastrectomy than in people with an intact stomach.

    Outcome
    DecreaseTBWL at 3 months, prior SG versus intact stomach
    Study

    n: not reported in source

    Comparator
    Patients with intact stomach
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    4.3%
    prior SG, 3 months
    TBWL
    5.7%
    intact stomach, 3 months

    Source sentences

    Summary
    Compared to patients with intact stomach (n = 87), GLP1/GIP-RA achieved significantly lower TBWL% in patients with prior SG at 3 (4.3% vs. 5.7%, p = .02)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  7. 10HumanNot a test of Semaglutide aloneObservational studyEfficacy outcome

    Pooled GLP1/GIP-RA (including semaglutide) gave lower 6-month TBWL in patients with prior sleeve gastrectomy than in patients with an intact stomach (6.8% versus 9.2%).

    In plain wordsGLP-1 type drugs as a group gave less weight loss at 6 months after sleeve gastrectomy than in people with an intact stomach.

    Outcome
    DecreaseTBWL at 6 months, prior SG versus intact stomach
    Study

    n: not reported in source

    Comparator
    Patients with intact stomach
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    6.8%
    prior SG, 6 months
    TBWL
    9.2%
    intact stomach, 6 months

    Source sentences

    Summary
    6 (6.8% vs. 9.2%, p = .02)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  8. 11HumanNot a test of Semaglutide aloneObservational studyEfficacy outcome

    Pooled GLP1/GIP-RA (including semaglutide) gave lower 12-month TBWL in patients with prior sleeve gastrectomy than in patients with an intact stomach (9.2% versus 12.7%).

    In plain wordsGLP-1 type drugs as a group gave less weight loss at 12 months after sleeve gastrectomy than in people with an intact stomach.

    Outcome
    DecreaseTBWL at 12 months, prior SG versus intact stomach
    Study

    n: not reported in source

    Comparator
    Patients with intact stomach
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    9.2%
    prior SG, 12 months
    TBWL
    12.7%
    intact stomach, 12 months

    Source sentences

    Summary
    12 months (9.2% vs. 12.7%, p = .03)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  9. 12HumanNot a test of Semaglutide aloneObservational studyOther

    Medication refills were difficult in 41.3% of patients in the study.

    In plain wordsRefilling the medicine was difficult for 41.3% of patients in the study.

    Outcome
    Not applicableDifficult medication refills
    Study

    n: not reported in source

    Outcome group
    Patterns of use · Whole body

    Measurements

    Patients with difficult refills
    41.3%
    study patients

    Source sentences

    Summary
    Medication refills were difficult in 41.3% of patients.
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Semaglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semaglutide.

  10. 13HumanNot a test of Tirzepatide aloneObservational studyEfficacy outcome

    After sleeve gastrectomy, pooled GLP1/GIP-RA (including tirzepatide) gave lower 3-month TBWL than R-ESG (4.3% versus 11.2%).

    In plain wordsAfter sleeve gastrectomy, GLP-1 type drugs as a group gave less weight loss at 3 months than a repeat endoscopic procedure.

    Outcome
    DecreaseTBWL at 3 months, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    4.3%
    GLP1/GIP-RA, 3 months
    TBWL
    11.2%
    R-ESG, 3 months

    Source sentences

    Summary
    R-ESG offered higher TBWL% than GLP1/GIP-RA at 3 (11.2% vs. 4.3%, p < .001)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

  11. 14HumanNot a test of Tirzepatide aloneObservational studyEfficacy outcome

    After sleeve gastrectomy, pooled GLP1/GIP-RA (including tirzepatide) gave lower 6-month TBWL than R-ESG (6.8% versus 13.5%).

    In plain wordsAfter sleeve gastrectomy, GLP-1 type drugs as a group gave less weight loss at 6 months than a repeat endoscopic procedure.

    Outcome
    DecreaseTBWL at 6 months, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    6.8%
    GLP1/GIP-RA, 6 months
    TBWL
    13.5%
    R-ESG, 6 months

    Source sentences

    Summary
    6 (13.5% vs. 6.8%, p < .001)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

  12. 15HumanNot a test of Tirzepatide aloneObservational studyEfficacy outcome

    After sleeve gastrectomy, 12-month TBWL for pooled GLP1/GIP-RA (including tirzepatide) was not significantly different from R-ESG (9.2% versus 13.4%).

    In plain wordsAfter sleeve gastrectomy, GLP-1 type drugs as a group did not differ significantly from a repeat endoscopic procedure in weight loss at 12 months.

    Outcome
    No significant changeTBWL at 12 months, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    9.2%
    GLP1/GIP-RA, 12 months
    TBWL
    13.4%
    R-ESG, 12 months

    Source sentences

    Summary
    12 months (13.4% vs. 9.2%, p = .07)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

  13. 16HumanNot a test of Tirzepatide aloneObservational studySafety outcome

    After sleeve gastrectomy, adverse events did not differ significantly between R-ESG and pooled GLP1/GIP-RA (including tirzepatide).

    In plain wordsAfter sleeve gastrectomy, side effects were not clearly different between a repeat endoscopic procedure and GLP-1 type drugs as a group.

    Outcome
    No significant changeAdverse events, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Adverse events · Whole body

    Source sentences

    Summary
    with no significant difference in AEs or change in metabolic parameters
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

  14. 17HumanNot a test of Tirzepatide aloneObservational studyEfficacy outcome

    After sleeve gastrectomy, change in metabolic parameters did not differ significantly between R-ESG and pooled GLP1/GIP-RA (including tirzepatide).

    In plain wordsAfter sleeve gastrectomy, changes in blood measures were not clearly different between a repeat endoscopic procedure and GLP-1 type drugs as a group.

    Outcome
    No significant changeMetabolic parameters, R-ESG versus GLP1/GIP-RA
    Study

    n: not reported in source

    Comparator
    R-ESG
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    with no significant difference in AEs or change in metabolic parameters
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

  15. 18HumanNot a test of Tirzepatide aloneObservational studyEfficacy outcome

    Pooled GLP1/GIP-RA (including tirzepatide) gave lower 3-month TBWL in patients with prior sleeve gastrectomy than in patients with an intact stomach (4.3% versus 5.7%).

    In plain wordsGLP-1 type drugs as a group gave less weight loss at 3 months after sleeve gastrectomy than in people with an intact stomach.

    Outcome
    DecreaseTBWL at 3 months, prior SG versus intact stomach
    Study

    n: not reported in source

    Comparator
    Patients with intact stomach
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    4.3%
    prior SG, 3 months
    TBWL
    5.7%
    intact stomach, 3 months

    Source sentences

    Summary
    Compared to patients with intact stomach (n = 87), GLP1/GIP-RA achieved significantly lower TBWL% in patients with prior SG at 3 (4.3% vs. 5.7%, p = .02)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

  16. 19HumanNot a test of Tirzepatide aloneObservational studyEfficacy outcome

    Pooled GLP1/GIP-RA (including tirzepatide) gave lower 6-month TBWL in patients with prior sleeve gastrectomy than in patients with an intact stomach (6.8% versus 9.2%).

    In plain wordsGLP-1 type drugs as a group gave less weight loss at 6 months after sleeve gastrectomy than in people with an intact stomach.

    Outcome
    DecreaseTBWL at 6 months, prior SG versus intact stomach
    Study

    n: not reported in source

    Comparator
    Patients with intact stomach
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    6.8%
    prior SG, 6 months
    TBWL
    9.2%
    intact stomach, 6 months

    Source sentences

    Summary
    6 (6.8% vs. 9.2%, p = .02)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

  17. 20HumanNot a test of Tirzepatide aloneObservational studyEfficacy outcome

    Pooled GLP1/GIP-RA (including tirzepatide) gave lower 12-month TBWL in patients with prior sleeve gastrectomy than in patients with an intact stomach (9.2% versus 12.7%).

    In plain wordsGLP-1 type drugs as a group gave less weight loss at 12 months after sleeve gastrectomy than in people with an intact stomach.

    Outcome
    DecreaseTBWL at 12 months, prior SG versus intact stomach
    Study

    n: not reported in source

    Comparator
    Patients with intact stomach
    Outcome group
    Body weight · Metabolic and weight

    Measurements

    TBWL
    9.2%
    prior SG, 12 months
    TBWL
    12.7%
    intact stomach, 12 months

    Source sentences

    Summary
    12 months (9.2% vs. 12.7%, p = .03)
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

  18. 21HumanNot a test of Tirzepatide aloneObservational studyOther

    Medication refills were difficult in 41.3% of patients in the study.

    In plain wordsRefilling the medicine was difficult for 41.3% of patients in the study.

    Outcome
    Not applicableDifficult medication refills
    Study

    n: not reported in source

    Outcome group
    Patterns of use · Whole body

    Measurements

    Patients with difficult refills
    41.3%
    study patients

    Source sentences

    Summary
    Medication refills were difficult in 41.3% of patients.
    1 context sentence
    Summary · context
    A retrospective study of patients ≥18 years with prior SG treated with semaglutide, tirzepatide or R-ESG for weight recidivism between January 2019 and 2023 at large academic centre.

    In this study, Tirzepatide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Tirzepatide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    11 Oct 2026, 00:04 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:07 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:06 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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