Safety and efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists in patients with weight regain or insufficient weight loss after metabolic bariatric surgery: A systematic review and meta-analysis.

Esparham A, Mehri A, Dalili A, Richards J, Khorgami Z

Obesity reviews : an official journal of the International Association for the Study of Obesity12 Aug 2024Cited by 20 (Europe PMC)

PMID39134066DOI10.1111/obr.13811PepBankPUB-39134066

Publisher page PubMedAsk about this study

Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanSystematic reviewEfficacy outcome
In patients with weight regain or insufficient weight loss after bariatric surgery, pooled analysis showed liraglutide for 6 months or less changed weight by -7.02 kg.
In plain wordsAfter bariatric surgery, pooled studies linked liraglutide used for 6 months or less to a weight reduction of 7.02 kg.
Peptide
Liraglutide
Outcome
DecreaseWeight change after 6 months or less
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Studied dose
highest dose 3 mg per day · 6 months or lessAs given in this study (human).
Measurements
Mean difference in weight
−7.02 kg
liraglutide, ≤ 6 months
Source sentences
Summary
The mean differences in weight and body mass index after treatment were -7.02 kg or 3.07 kg/m², -8.65 or -5.22 kg/m², and -6.99 kg or -3.09 kg/m² for treatment durations of ≤ 6 months, 6-12 months, and >12 months with liraglutide, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 19 articles were included.
Summary · context
The highest doses of liraglutide and semaglutide were 3 mg per day and 1 mg once weekly, respectively, in the included studies.
Report a problemFND-3913406601
02HumanSystematic reviewEfficacy outcome
In patients with weight regain or insufficient weight loss after bariatric surgery, pooled analysis showed liraglutide for 6 months or less lowered BMI by 3.07 kg/m2.
In plain wordsAfter bariatric surgery, pooled studies linked liraglutide used for 6 months or less to a BMI reduction of 3.07 kg/m2.
Peptide
Liraglutide
Outcome
DecreaseBMI change after 6 months or less
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Studied dose
highest dose 3 mg per day · 6 months or lessAs given in this study (human).
Measurements
Mean difference in BMI
3.07 kg/m2
liraglutide, ≤ 6 months
Source sentences
Summary
The mean differences in weight and body mass index after treatment were -7.02 kg or 3.07 kg/m², -8.65 or -5.22 kg/m², and -6.99 kg or -3.09 kg/m² for treatment durations of ≤ 6 months, 6-12 months, and >12 months with liraglutide, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 19 articles were included.
Summary · context
The highest doses of liraglutide and semaglutide were 3 mg per day and 1 mg once weekly, respectively, in the included studies.
Report a problemFND-3913406602
03HumanSystematic reviewEfficacy outcome
In patients with weight regain or insufficient weight loss after bariatric surgery, pooled analysis showed liraglutide for 6-12 months changed weight by -8.65 (unit not stated).
In plain wordsAfter bariatric surgery, pooled studies linked liraglutide used for 6-12 months to a weight reduction of 8.65.
Peptide
Liraglutide
Outcome
DecreaseWeight change after 6-12 months
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Studied dose
highest dose 3 mg per day · 6-12 monthsAs given in this study (human).
Measurements
Mean difference in weight
−8.65 unit not stated
liraglutide, 6-12 months
Source sentences
Summary
The mean differences in weight and body mass index after treatment were -7.02 kg or 3.07 kg/m², -8.65 or -5.22 kg/m², and -6.99 kg or -3.09 kg/m² for treatment durations of ≤ 6 months, 6-12 months, and >12 months with liraglutide, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 19 articles were included.
Summary · context
The highest doses of liraglutide and semaglutide were 3 mg per day and 1 mg once weekly, respectively, in the included studies.
Report a problemFND-3913406603
04HumanSystematic reviewEfficacy outcome
In patients with weight regain or insufficient weight loss after bariatric surgery, pooled analysis showed liraglutide for 6-12 months lowered BMI by 5.22 kg/m2.
In plain wordsAfter bariatric surgery, pooled studies linked liraglutide used for 6-12 months to a BMI reduction of 5.22 kg/m2.
Peptide
Liraglutide
Outcome
DecreaseBMI change after 6-12 months
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Studied dose
highest dose 3 mg per day · 6-12 monthsAs given in this study (human).
Measurements
Mean difference in BMI
−5.22 kg/m2
liraglutide, 6-12 months
Source sentences
Summary
The mean differences in weight and body mass index after treatment were -7.02 kg or 3.07 kg/m², -8.65 or -5.22 kg/m², and -6.99 kg or -3.09 kg/m² for treatment durations of ≤ 6 months, 6-12 months, and >12 months with liraglutide, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 19 articles were included.
Summary · context
The highest doses of liraglutide and semaglutide were 3 mg per day and 1 mg once weekly, respectively, in the included studies.
Report a problemFND-3913406604
05HumanSystematic reviewEfficacy outcome
In patients with weight regain or insufficient weight loss after bariatric surgery, pooled analysis showed liraglutide for more than 12 months changed weight by -6.99 kg.
In plain wordsAfter bariatric surgery, pooled studies linked liraglutide used for more than 12 months to a weight reduction of 6.99 kg.
Peptide
Liraglutide
Outcome
DecreaseWeight change after more than 12 months
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Studied dose
highest dose 3 mg per day · more than 12 monthsAs given in this study (human).
Measurements
Mean difference in weight
−6.99 kg
liraglutide, >12 months
Source sentences
Summary
The mean differences in weight and body mass index after treatment were -7.02 kg or 3.07 kg/m², -8.65 or -5.22 kg/m², and -6.99 kg or -3.09 kg/m² for treatment durations of ≤ 6 months, 6-12 months, and >12 months with liraglutide, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 19 articles were included.
Summary · context
The highest doses of liraglutide and semaglutide were 3 mg per day and 1 mg once weekly, respectively, in the included studies.
Report a problemFND-3913406605
06HumanSystematic reviewEfficacy outcome
In patients with weight regain or insufficient weight loss after bariatric surgery, pooled analysis showed liraglutide for more than 12 months lowered BMI by 3.09 kg/m2.
In plain wordsAfter bariatric surgery, pooled studies linked liraglutide used for more than 12 months to a BMI reduction of 3.09 kg/m2.
Peptide
Liraglutide
Outcome
DecreaseBMI change after more than 12 months
Study
n: not reported in source
Outcome group
Body weight · Metabolic and weight
Studied dose
highest dose 3 mg per day · more than 12 monthsAs given in this study (human).
Measurements
Mean difference in BMI
−3.09 kg/m2
liraglutide, >12 months
Source sentences
Summary
The mean differences in weight and body mass index after treatment were -7.02 kg or 3.07 kg/m², -8.65 or -5.22 kg/m², and -6.99 kg or -3.09 kg/m² for treatment durations of ≤ 6 months, 6-12 months, and >12 months with liraglutide, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 19 articles were included.
Summary · context
The highest doses of liraglutide and semaglutide were 3 mg per day and 1 mg once weekly, respectively, in the included studies.
Report a problemFND-3913406606
07HumanSystematic reviewEfficacy outcome
In patients with weight regain or insufficient weight loss after bariatric surgery, weekly semaglutide gave significantly greater weight loss than daily liraglutide (mean difference 4.15 kg).
In plain wordsAfter bariatric surgery, weekly semaglutide led to more weight loss than daily liraglutide in pooled studies.
Peptide
Semaglutide
Outcome
DecreaseWeight loss versus liraglutide
Study
n: not reported in source
Comparator
Liraglutide (daily)
Outcome group
Body weight · Metabolic and weight
Studied dose
highest dose 1 mg once weeklyAs given in this study (human).
Measurements
Mean difference in weight loss
4.15 kg
semaglutide weekly vs liraglutide daily
Source sentences
Summary
Additionally, weekly semaglutide showed significantly greater weight loss compared to daily liraglutide, with a mean difference of 4.15 kg.
2 context sentences(design, population, supporting numbers)
Summary · context
A total of 19 articles were included.
Summary · context
The highest doses of liraglutide and semaglutide were 3 mg per day and 1 mg once weekly, respectively, in the included studies.
Report a problemFND-3913406607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:06 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Safety and efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists in patients with weight regain or insufficient weight loss after metabolic bariatric surgery: A systematic review and meta-analysis.

Summary

Results from this study7

Version history

Subjects

Publication types

MeSH terms

Keywords