Effectiveness of the triptorelin stimulation test compared with the classic gonadotropin-releasing hormone stimulation test in diagnosing central precocious puberty in girls.

Kim YJ, Hwangbo J, Park KH, Kang E, Nam HK, Rhie YJ, Lee KH

Annals of pediatric endocrinology & metabolism30 Apr 2024Cited by 8 (Europe PMC)

PMID38712492PMCIDPMC11076232DOI10.6065/apem.2346054.027PepBankPUB-38712492

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Summary

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Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. 4 results from people.

01HumanObservational studyActivity measurement
In girls with premature thelarche, both triptorelin and gonadorelin tests reached the highest LH level at 60 minutes.
In plain wordsIn girls with premature breast development, both triptorelin and gonadorelin tests reached the highest LH level at 60 minutes.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableTime to peak LH
Study
n = 100
Comparator
Gonadorelin stimulation test
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · subcutaneousAs given in this study (human).
Measurements
Time to highest LH
60 minutes
both stimulation tests
Source sentences
Summary
The highest LH level was reached 60 minutes after stimulation in both groups.
2 context sentences(design, population, supporting numbers)
Summary · context
This retrospective study included 100 girls with premature thelarche (PT) who underwent a hypothalamic-pituitary-gonadal axis evaluation.
Summary · context
In the overall group, 50 girls were tested with intravenous gonadorelin (Relefact) and 50 girls were tested with subcutaneous triptorelin acetate (Decapeptyl).
Report a problemFND-3871249204
02HumanObservational studyActivity measurement
In girls with premature thelarche, the highest LH level was reached 60 minutes after intravenous gonadorelin, as it was after triptorelin.
In plain wordsIn girls with premature thelarche, LH peaked 60 minutes after gonadorelin, as it did after triptorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableTime of highest LH level after stimulation
Study
n = 50
Comparator
Subcutaneous triptorelin
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
Time to highest LH
60 minutes
gonadorelin
Source sentences
Summary
The highest LH level was reached 60 minutes after stimulation in both groups.
2 context sentences(design, population, supporting numbers)
Summary · context
This retrospective study included 100 girls with premature thelarche (PT) who underwent a hypothalamic-pituitary-gonadal axis evaluation.
Summary · context
In the overall group, 50 girls were tested with intravenous gonadorelin (Relefact) and 50 girls were tested with subcutaneous triptorelin acetate (Decapeptyl).
Report a problemFND-3871249201
03HumanObservational studyOther
In girls with premature thelarche, about 20% were diagnosed with central precocious puberty after gonadorelin testing, not significantly different from triptorelin (24%).
In plain wordsIn girls with premature thelarche, about 20% were diagnosed with central precocious puberty after gonadorelin, similar to the 24% with triptorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeProportion diagnosed with central precocious puberty
Study
n = 50
Comparator
Subcutaneous triptorelin
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
Diagnosed with CPP
≈ 20%
gonadorelin group
Source sentences
Summary
Approximately 20% of the gonadorelin group and 24% of the triptorelin group were diagnosed with CPP (P=0.52).
2 context sentences(design, population, supporting numbers)
Summary · context
This retrospective study included 100 girls with premature thelarche (PT) who underwent a hypothalamic-pituitary-gonadal axis evaluation.
Summary · context
In the overall group, 50 girls were tested with intravenous gonadorelin (Relefact) and 50 girls were tested with subcutaneous triptorelin acetate (Decapeptyl).
Report a problemFND-3871249202
04HumanObservational studyActivity measurement
In girls diagnosed with central precocious puberty, the mean peak LH after gonadorelin was 8.15 mIU/mL, against 9.73 mIU/mL after triptorelin.
In plain wordsIn girls with central precocious puberty, mean peak LH was 8.15 mIU/mL after gonadorelin and 9.73 mIU/mL after triptorelin.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableMean peak LH concentration in girls with central precocious puberty
Study
n = 50
Comparator
Subcutaneous triptorelin
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
Mean peak LH
8.15 mIU/mL
gonadorelin, CPP
Source sentences
Summary
Among those diagnosed with CPP, the mean peak LH concentrations were 8.15 mIU/mL and 9.73 mIU/mL in the gonadorelin and triptorelin groups, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
This retrospective study included 100 girls with premature thelarche (PT) who underwent a hypothalamic-pituitary-gonadal axis evaluation.
Summary · context
In the overall group, 50 girls were tested with intravenous gonadorelin (Relefact) and 50 girls were tested with subcutaneous triptorelin acetate (Decapeptyl).
Report a problemFND-3871249203

Studies that did not test the peptide alone2

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In girls with premature thelarche, CPP diagnostic rates were similar with triptorelin and gonadorelin tests, at 24% and approximately 20%, respectively.
In plain wordsIn girls with premature breast development, diagnosis rates were similar with triptorelin and gonadorelin tests.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeCPP diagnostic rate
Study
n = 100
Comparator
Gonadorelin stimulation test
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
CPP diagnostic rate
24%
triptorelin
CPP diagnostic rate
≈ 20%
gonadorelin
P value
0.52
between tests
Source sentences
Summary
Approximately 20% of the gonadorelin group and 24% of the triptorelin group were diagnosed with CPP (P=0.52).
2 context sentences(design, population, supporting numbers)
Summary · context
This retrospective study included 100 girls with premature thelarche (PT) who underwent a hypothalamic-pituitary-gonadal axis evaluation.
Summary · context
In the overall group, 50 girls were tested with intravenous gonadorelin (Relefact) and 50 girls were tested with subcutaneous triptorelin acetate (Decapeptyl).
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-3871249205
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
Among girls diagnosed with CPP, mean peak LH was 9.73 mIU/mL with triptorelin and 8.15 mIU/mL with gonadorelin.
In plain wordsAmong girls diagnosed with early central puberty, peak LH averaged 9.73 mIU/mL with triptorelin versus 8.15 mIU/mL with gonadorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedPeak LH in girls diagnosed with CPP
Study
n: not reported in source
Comparator
Gonadorelin stimulation test
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Mean peak LH
9.73 mIU/mL
triptorelin; CPP subgroup
Mean peak LH
8.15 mIU/mL
gonadorelin; CPP subgroup
Source sentences
Summary
Among those diagnosed with CPP, the mean peak LH concentrations were 8.15 mIU/mL and 9.73 mIU/mL in the gonadorelin and triptorelin groups, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
This retrospective study included 100 girls with premature thelarche (PT) who underwent a hypothalamic-pituitary-gonadal axis evaluation.
Summary · context
In the overall group, 50 girls were tested with intravenous gonadorelin (Relefact) and 50 girls were tested with subcutaneous triptorelin acetate (Decapeptyl).
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-3871249206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 2
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Effectiveness of the triptorelin stimulation test compared with the classic gonadotropin-releasing hormone stimulation test in diagnosing central precocious puberty in girls.

Summary

Results from this study6

Studies that did not test the peptide alone2

Version history

Subjects

Publication types

Keywords