Use of the Subcutaneous Triptorelin Stimulation Test for Diagnosis of Central Precocious Puberty.

Ahn J, Lee Y, Gim S, Jeong H

Children (Basel, Switzerland)20 Nov 2023Cited by 5 (Europe PMC)

PMID38002921DOI10.3390/children10111830PepBankPUB-38002921

Publisher page PubMedAsk about this study

Summary

BackgroundThe gold standard gonadotropin-releasing hormone (GnRH) stimulation test uses the response to intravenously injected gonadorelin to diagnose central precocious puberty (CPP). However, gonadorelin is not always readily available.ObjectiveThis study investigated the diagnostic efficacy of the subcutaneous triptorelin test and the optimal blood sampling time for diagnosis of CPP.MethodsThis study retrospectively examined the medical records of 220 girls who had undergone either the triptorelin or gonadorelin test and compared their clinical characteristics. We retrospectively compared clinical parameters between girls diagnosed with CPP (n = 111) and idiopathic premature thelarche (IPT) (n = 109) using three different diagnostic methods: the gonadorelin, triptorelin 120 min, and triptorelin 180 min tests. The diagnostic ability of the stimulated luteinizing hormone (LH) concentration in the triptorelin test for CPP was evaluated using receiver operating characteristic (ROC) analysis.ResultsThe CPP group exhibited higher basal and peak gonadotropin levels, more advanced bone age, and a lower body mass index standard deviation score than the IPT group. In the gonadorelin test group, all girls with CPP exhibited a peak LH response 30-60 min after intravenous gonadorelin injection. In the triptorelin test group, most girls with CPP exhibited a peak LH response 60-180 min after subcutaneous triptorelin injection (n = 68). On the ROC curve, a peak LH concentration of ≥ 4.52 IU/L at 120 min had the highest CPP diagnostic accuracy, with sensitivity and specificity of 100% and 95.83%, respectively.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

1 result from studies that gave the peptide. 1 result from people.

01HumanObservational studyActivity measurement
In girls with central precocious puberty, all had a peak LH response 30-60 minutes after intravenous gonadorelin.
In plain wordsIn girls with central precocious puberty, LH peaked 30 to 60 minutes after gonadorelin in every girl.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableTiming of peak LH response after gonadorelin
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
Time to peak LH
30 to 60 min
gonadorelin, CPP
Source sentences
Summary
In the gonadorelin test group, all girls with CPP exhibited a peak LH response 30-60 min after intravenous gonadorelin injection.
1 context sentence(design, population, supporting numbers)
Summary · context
This study retrospectively examined the medical records of 220 girls who had undergone either the triptorelin or gonadorelin test and compared their clinical characteristics.
Show in the study text Report a problemFND-3800292101

Studies that did not test the peptide alone3

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
Most girls with CPP in the triptorelin test group showed a peak LH response 60-180 min after injection.
In plain wordsMost girls with early central puberty in the triptorelin test group reached peak LH 60-180 min after injection.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableTiming of peak LH response
Study
n = 68
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Time to peak LH
60 to 180 min
most girls with CPP; triptorelin test
Source sentences
Summary
In the triptorelin test group, most girls with CPP exhibited a peak LH response 60-180 min after subcutaneous triptorelin injection (n = 68).
2 context sentences(design, population, supporting numbers)
Summary · context
This study retrospectively examined the medical records of 220 girls who had undergone either the triptorelin or gonadorelin test and compared their clinical characteristics.
Summary · context
The diagnostic ability of the stimulated luteinizing hormone (LH) concentration in the triptorelin test for CPP was evaluated using receiver operating characteristic (ROC) analysis.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3800292102
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In girls evaluated for CPP, the triptorelin test had 100% sensitivity at a peak LH threshold of ≥ 4.52 IU/L at 120 min.
In plain wordsIn girls evaluated for early central puberty, the triptorelin test had 100% sensitivity at the reported LH threshold.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableCPP diagnostic sensitivity
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Sensitivity
100%
peak LH ≥ 4.52 IU/L at 120 min
Peak LH threshold
≥ 4.52 IU/L
120 min
Source sentences
Summary
On the ROC curve, a peak LH concentration of ≥ 4.52 IU/L at 120 min had the highest CPP diagnostic accuracy, with sensitivity and specificity of 100% and 95.83%, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
This study retrospectively examined the medical records of 220 girls who had undergone either the triptorelin or gonadorelin test and compared their clinical characteristics.
Summary · context
The diagnostic ability of the stimulated luteinizing hormone (LH) concentration in the triptorelin test for CPP was evaluated using receiver operating characteristic (ROC) analysis.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3800292103
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In girls evaluated for CPP, the triptorelin test had 95.83% specificity at a peak LH threshold of ≥ 4.52 IU/L at 120 min.
In plain wordsIn girls evaluated for early central puberty, the triptorelin test had 95.83% specificity at the reported LH threshold.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableCPP diagnostic specificity
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Specificity
95.83%
peak LH ≥ 4.52 IU/L at 120 min
Source sentences
Summary
On the ROC curve, a peak LH concentration of ≥ 4.52 IU/L at 120 min had the highest CPP diagnostic accuracy, with sensitivity and specificity of 100% and 95.83%, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
This study retrospectively examined the medical records of 220 girls who had undergone either the triptorelin or gonadorelin test and compared their clinical characteristics.
Summary · context
The diagnostic ability of the stimulated luteinizing hormone (LH) concentration in the triptorelin test for CPP was evaluated using receiver operating characteristic (ROC) analysis.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3800292104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 2
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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