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Study · Measured the body's own peptide · 2022

5 results

NAD supplementation improves mitochondrial performance of cardiolipin mutants.

Ji J, Damschroder D, Bessert D, Lazcano P, Wessells R, Reynolds CA, Greenberg ML

Biochimica et biophysica acta. Molecular and cell biology of lipids18 Jan 2022Cited by 21 (Europe PMC)

PMID35051613 (opens in a new tab)PMCIDPMC8883178 (opens in a new tab)DOI10.1016/j.bbalip.2021.159094 (opens in a new tab)PepBankPUB-35051613
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelOther designMechanism

    In multiple Barth syndrome model systems, natural NAD+ metabolism was abnormal.

    In plain wordsIn lab models of Barth syndrome, the body's own NAD+ metabolism was abnormal.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    Direction not reportedNAD+ metabolism
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Pharmacology

    Source sentences

    Summary
    In this study, we identified abnormal NAD+ metabolism in multiple BTHS model systems

    This result measures the body's own NAD+ (nicotinamide adenine dinucleotide). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone4

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 02AnimalNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In Drosophila, improved mitochondrial function after NAD+ precursor supplementation was associated with restored exercise endurance.

    In plain wordsIn Drosophila, better mitochondrial function after NAD+ precursor supplementation was linked to restored exercise endurance.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseExercise endurance
    Study

    Drosophilan: not reported in source

    Barth syndrome model
    Outcome group
    Exercise and physical function · Musculoskeletal

    Source sentences

    Summary
    Improved mitochondrial function in the Drosophila model was associated with restored exercise endurance, which suggests a potential therapeutic benefit of NAD+ precursor supplementation in the management of BTHS patients.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  2. 03AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In Drosophila, improved mitochondrial function with NAD+ precursor supplementation was associated with restored exercise endurance.

    In plain wordsIn Drosophila, better mitochondrial function with NAD+ precursors was linked to restored exercise endurance.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseExercise endurance
    Study

    Drosophilan: not reported in source

    Drosophila Barth syndrome model
    Outcome group
    Exercise and physical function · Musculoskeletal

    Source sentences

    Summary
    Improved mitochondrial function in the Drosophila model was associated with restored exercise endurance, which suggests a potential therapeutic benefit of NAD+ precursor supplementation in the management of BTHS patients.
    1 context sentence
    Summary · context
    In this study, we identified abnormal NAD+ metabolism in multiple BTHS model systems and demonstrate that supplementation of NAD+ precursors such as nicotinamide mononucleotide (NMN) improves mitochondrial function.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  3. 04AnimalNot a test of NMN (nicotinamide mononucleotide) aloneOther designEfficacy outcome

    In Barth syndrome model systems, supplementation with NAD+ precursors such as NMN improved mitochondrial function.

    In plain wordsIn Barth syndrome models, NAD+ precursors such as NMN improved mitochondrial function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial function
    Study

    n: not reported in source

    Multiple Barth syndrome model systems
    Outcome group
    Mitochondrial function · Metabolic and weight

    Source sentences

    Summary
    In this study, we identified abnormal NAD+ metabolism in multiple BTHS model systems and demonstrate that supplementation of NAD+ precursors such as nicotinamide mononucleotide (NMN) improves mitochondrial function.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  4. 05LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneOther designEfficacy outcome

    In Barth syndrome model systems, NAD+ precursor supplementation such as NMN improved mitochondrial function.

    In plain wordsIn lab models of Barth syndrome, NAD+ precursors such as NMN improved mitochondrial function.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseMitochondrial function
    Study

    n: not reported in source

    Outcome group
    Mitochondrial function · Whole body

    Source sentences

    Summary
    In this study, we identified abnormal NAD+ metabolism in multiple BTHS model systems and demonstrate that supplementation of NAD+ precursors such as nicotinamide mononucleotide (NMN) improves mitochondrial function.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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