Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.

Lee E, Padgett B

Alternative therapies in health and medicine1 Jul 2021Cited by 19 (Europe PMC)

PMID34324435PepBankPUB-34324435

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. 1 result from people.

01HumanObservational studyEfficacy outcome
In patients with knee pain, 11 of 12 who received only intra-articular BPC‑157 (91.6%) reported significant improvement in knee pain and 1 (8.3%) reported none.
In plain wordsIn a small survey of patients with knee pain, most of those who got only BPC‑157 injections reported clear pain improvement.
Peptide
BPC-157
Outcome
DecreaseKnee pain improvement (patient-reported)
Study
n = 12
Outcome group
Pain · Musculoskeletal
Studied dose
Dose not stated · intra-articular injectionAs given in this study (human).
Measurements
Patients with significant improvement
91.6%
BPC 157 alone
Source sentences
Summary
Of the 16 patients, 12 had received only BPC 157 as an intra-articular injection. In this group, 11 of the 12 patients (91.6%) had significant improvement in knee pain, whereas 1 patient (8.3 %) had no improvement.
2 context sentences(design, population, supporting numbers)
Summary · context
A retrospective study was done at the Institute for Hormonal Balance in Orlando, Florida, USA to see whether intra-articular injection of the peptide BPC 157, alone or combined with TB4, helped relieve knee pain.
Summary · context
Of the 17 patients in the study, 16 were contacted by phone to follow up on the status of their knee pain.
Report a problemFND-3432443501

Studies that did not test the peptide alone4

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

02HumanNot a test of BPC-157 aloneObservational studyEfficacy outcome
In patients with knee pain, 14 of 16 (87.5%) had relief when BPC‑157 alone or BPC‑157 with TB4 was used; this result pools both regimens.
In plain wordsIn a small survey of patients with knee pain, most reported relief after BPC‑157 alone or with another peptide.
Peptide
BPC-157
Outcome
DecreaseKnee pain improvement (patient-reported)
Study
n = 16
Outcome group
Pain · Musculoskeletal
Measurements
Patients with pain relief
87.5%
BPC 157 alone or with TB4
Source sentences
Summary
Overall, 14 of 16 patients (87.5%) had relief of their knee pain when BPC 157 or a combination of BPC 157 and TB4 was used.
2 context sentences(design, population, supporting numbers)
Summary · context
A retrospective study was done at the Institute for Hormonal Balance in Orlando, Florida, USA to see whether intra-articular injection of the peptide BPC 157, alone or combined with TB4, helped relieve knee pain.
Summary · context
Of the 17 patients in the study, 16 were contacted by phone to follow up on the status of their knee pain.
In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.
Report a problemFND-3432443503
03HumanNot a test of Thymosin beta-4 (human) aloneObservational studyEfficacy outcome
In adults with knee pain, 14 of 16 patients had pain relief after intra-articular BPC 157 alone or BPC 157 combined with TB4 (pooled).
In plain wordsIn adults with knee pain, 14 of 16 people reported relief after a knee injection of BPC 157, alone or with TB4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseKnee pain improvement (patient-reported)
Study
n = 16
Outcome group
Pain · Musculoskeletal
Measurements
Patients with relief
14 patients
BPC 157 alone or with TB4
Proportion with relief
87.5%
BPC 157 alone or with TB4
Source sentences
Summary
Overall, 14 of 16 patients (87.5%) had relief of their knee pain when BPC 157 or a combination of BPC 157 and TB4 was used.
2 context sentences(design, population, supporting numbers)
Summary · context
A retrospective study was done at the Institute for Hormonal Balance in Orlando, Florida, USA to see whether intra-articular injection of the peptide BPC 157, alone or combined with TB4, helped relieve knee pain.
Summary · context
Of the 17 patients in the study, 16 were contacted by phone to follow up on the status of their knee pain.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3432443505
04HumanNot a test of BPC-157 aloneObservational studyEfficacy outcome
In patients with knee pain, a combination of intra-articular BPC‑157 and TB4 was followed by significant improvement in 75% and no relief in 25%.
In plain wordsIn a small survey of patients with knee pain, most who got a BPC‑157 plus TB4 injection reported improvement; one in four did not.
Peptide
BPC-157
Outcome
DecreaseKnee pain improvement (patient-reported)
Study
n = 4
Outcome group
Pain · Musculoskeletal
Measurements
Patients with significant improvement
75%
BPC 157 plus TB4
Source sentences
Summary
The other 4 patients received a combination of 2 peptide injections of BPC 157 and TB4. Of the patients who received both peptides, 75% showed significant improvement, but 25% had no relief of their knee pain.
2 context sentences(design, population, supporting numbers)
Summary · context
A retrospective study was done at the Institute for Hormonal Balance in Orlando, Florida, USA to see whether intra-articular injection of the peptide BPC 157, alone or combined with TB4, helped relieve knee pain.
Summary · context
Of the 17 patients in the study, 16 were contacted by phone to follow up on the status of their knee pain.
In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.
Report a problemFND-3432443502
05HumanNot a test of Thymosin beta-4 (human) aloneObservational studyEfficacy outcome
In adults with knee pain, 75% of 4 patients who received intra-articular BPC 157 together with TB4 showed significant improvement and 25% had no relief.
In plain wordsIn adults with knee pain, 75% of 4 people who got BPC 157 and TB4 injected together reported clear improvement. There was no comparison group.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseKnee pain improvement (patient-reported)
Study
n = 4
Outcome group
Pain · Musculoskeletal
Measurements
Proportion improved
75%
BPC 157 plus TB4
Source sentences
Summary
The other 4 patients received a combination of 2 peptide injections of BPC 157 and TB4. Of the patients who received both peptides, 75% showed significant improvement, but 25% had no relief of their knee pain.
2 context sentences(design, population, supporting numbers)
Summary · context
A retrospective study was done at the Institute for Hormonal Balance in Orlando, Florida, USA to see whether intra-articular injection of the peptide BPC 157, alone or combined with TB4, helped relieve knee pain.
Summary · context
Of the 17 patients in the study, 16 were contacted by phone to follow up on the status of their knee pain.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3432443504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
12 Oct 2026, 18:17 UTC
Study data updated · source update from Europe PMC
Version 3
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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