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Study · Ex vivo tissue · rat · 2015

7 results

[POLYPEPTIDES INFLUENCE ON TISSUE CELL CULTURES REGENERATION OF VARIOUS AGE RATS].

Ryzhak AP, Chalisova NI, Lin'kova NS, Khalimov RI, Ryzhak GA, Zhekalov AN

Advances in gerontology = Uspekhi gerontologii1 Jan 2015

PMID26390619 (opens in a new tab)PepBankPUB-26390619
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat organotypic cultures, Thymalin activated CD5 expression, which the abstract identifies as a B-cell differentiation marker.

    In plain wordsIn lab tests of rat cultures, Thymalin increased expression of CD5, described as a B-cell differentiation marker.

    Peptide
    Thymalin
    Outcome
    IncreaseCD5 expression
    Study

    ratn: not reported in source

    Organotypic tissue cultures of young and old rats
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, Thymalin activated CD5, CD20 expression--markers of B-cells differentiation.
    1 context sentence
    Summary · context
    on the relevant organotypic tissue cultures of young and old rats, in concentration 0,01-100 ng/ml was performed.
  2. 02LabEx vivo tissueMechanism

    In rat organotypic cultures, Thymalin activated CD20 expression, which the abstract identifies as a B-cell differentiation marker.

    In plain wordsIn lab tests of rat cultures, Thymalin increased expression of CD20, described as a B-cell differentiation marker.

    Peptide
    Thymalin
    Outcome
    IncreaseCD20 expression
    Study

    ratn: not reported in source

    Organotypic tissue cultures of young and old rats
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, Thymalin activated CD5, CD20 expression--markers of B-cells differentiation.
    1 context sentence
    Summary · context
    on the relevant organotypic tissue cultures of young and old rats, in concentration 0,01-100 ng/ml was performed.

Studies that did not test the peptide alone5

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 03LabNot a test of Thymalin aloneEx vivo tissueMechanism

    In young rat organotypic cultures, pooled tissue polypeptides including Thymalin stimulated growth at 20-50 ng/ml.

    In plain wordsIn lab tests, pooled tissue polypeptides including Thymalin increased growth of young rat cultures.

    Peptide
    Thymalin
    Outcome
    IncreaseYoung cell culture growth
    Study

    ratn: not reported in source

    Organotypic tissue cultures of young and old rats
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Measurements

    Polypeptide concentration
    20 to 50 ng/ml
    Pooled tissue polypeptides

    Source sentences

    Summary
    Polypeptides specifically stimulated "young" and "old" cell cultures growth in concentration 20-50 ng/ml.
    1 context sentence
    Summary · context
    on the relevant organotypic tissue cultures of young and old rats, in concentration 0,01-100 ng/ml was performed.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

  2. 04LabNot a test of Thymalin aloneEx vivo tissueMechanism

    In old rat organotypic cultures, pooled tissue polypeptides including Thymalin stimulated growth at 20-50 ng/ml.

    In plain wordsIn lab tests, pooled tissue polypeptides including Thymalin increased growth of old rat cultures.

    Peptide
    Thymalin
    Outcome
    IncreaseOld cell culture growth
    Study

    ratn: not reported in source

    Organotypic tissue cultures of young and old rats
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Measurements

    Polypeptide concentration
    20 to 50 ng/ml
    Pooled tissue polypeptides

    Source sentences

    Summary
    Polypeptides specifically stimulated "young" and "old" cell cultures growth in concentration 20-50 ng/ml.
    1 context sentence
    Summary · context
    on the relevant organotypic tissue cultures of young and old rats, in concentration 0,01-100 ng/ml was performed.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

  3. 05LabNot a test of Cortexin (cortical polypeptide complex) aloneEx vivo tissueMechanism

    In rat tissue cultures, pooled tissue polypeptides including Cortexin stimulated growth of young and old cultures at 20-50 ng/ml.

    In plain wordsIn lab tests, tissue polypeptides including Cortexin stimulated growth of young and old rat tissue cultures.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseCulture growth
    Study

    ratn: not reported in source

    Young and old rat organotypic tissue cultures
    Outcome group
    Aging markers · Aging and longevity

    Measurements

    Active concentration
    20 to 50 ng/ml
    pooled tissue polypeptides

    Source sentences

    Summary
    Polypeptides specifically stimulated "young" and "old" cell cultures growth in concentration 20-50 ng/ml.
    1 context sentence
    Summary · context
    A comparative study of polypeptides extracted from the tissues of calves: Cortexin (from brain cortex), Epinorm (from pineal gland), Ventvil (from liver), Prostatilen (from prostate), Thymalin (from thymus), Chelohart (from heart), Chondrolux (from cartilage) on the relevant organotypic tissue cultu…

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  4. 06LabNot a test of Cortexin (cortical polypeptide complex) aloneEx vivo tissueMechanism

    In rat tissue cultures, growth stimulation by pooled polypeptides including Cortexin correlated with increased PCNA expression.

    In plain wordsIn lab tests, growth stimulation by tissue polypeptides including Cortexin correlated with increased PCNA expression in rat tissues.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreasePCNA expression
    Study

    ratn: not reported in source

    Young and old rat organotypic tissue cultures
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    This effect correlates with increasing of PCNA and decreasing of p53 expression in brain cortex, pineal gland, liver, prostate, heart, cartilage.
    2 context sentences
    Summary · context
    Polypeptides specifically stimulated "young" and "old" cell cultures growth in concentration 20-50 ng/ml.
    Summary · context
    A comparative study of polypeptides extracted from the tissues of calves: Cortexin (from brain cortex), Epinorm (from pineal gland), Ventvil (from liver), Prostatilen (from prostate), Thymalin (from thymus), Chelohart (from heart), Chondrolux (from cartilage) on the relevant organotypic tissue cultu…

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

  5. 07LabNot a test of Cortexin (cortical polypeptide complex) aloneEx vivo tissueMechanism

    In rat tissue cultures, growth stimulation by pooled polypeptides including Cortexin correlated with decreased p53 expression.

    In plain wordsIn lab tests, growth stimulation by tissue polypeptides including Cortexin correlated with reduced p53 expression in rat tissues.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Decreasep53 expression
    Study

    ratn: not reported in source

    Young and old rat organotypic tissue cultures
    Outcome group
    Aging markers · Aging and longevity

    Source sentences

    Summary
    This effect correlates with increasing of PCNA and decreasing of p53 expression in brain cortex, pineal gland, liver, prostate, heart, cartilage.
    2 context sentences
    Summary · context
    Polypeptides specifically stimulated "young" and "old" cell cultures growth in concentration 20-50 ng/ml.
    Summary · context
    A comparative study of polypeptides extracted from the tissues of calves: Cortexin (from brain cortex), Epinorm (from pineal gland), Ventvil (from liver), Prostatilen (from prostate), Thymalin (from thymus), Chelohart (from heart), Chondrolux (from cartilage) on the relevant organotypic tissue cultu…

    In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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