In an 8-year-old girl with central precocious puberty, intravenous gonadorelin acetate caused severe anaphylaxis with loss of consciousness and tonic seizures within 3 minutes.
In plain wordsIn one 8-year-old girl with early puberty, gonadorelin acetate given into a vein caused a severe allergic reaction within minutes.
- Peptide
- Gonadorelin (GnRH, LHRH)
- Outcome
- Not applicableAnaphylaxis after intravenous gonadorelin acetate
- Study
n = 1
- Outcome group
- Adverse events · Immune and inflammation
- Studied dose
- Dose not stated · intravenousAs given in this study (human).
Source sentences
Herein, we described - to the best of our knowledge - the first pediatric case in which severe anaphylaxis was encountered after intravenous gonadorelin acetate administration.
2 context sentences(design, population, supporting numbers)
Within 3 min after intravenous administration of gonadorelin acetate, she lost consciousness and tonic seizures began in her hands and feet.
An 8-year-old girl who was diagnosed with central precocious puberty was receiving triptorelin acetate treatment uneventfully for 6 months.