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Study · Systematic review · 2013

4 results

Blood pressure-lowering effects of GLP-1 receptor agonists exenatide and liraglutide: a meta-analysis of clinical trials.

Wang B, Zhong J, Lin H, Zhao Z, Yan Z, He H, Ni Y, Liu D, Zhu Z

Diabetes, obesity & metabolism20 Mar 2013Cited by 178 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanSystematic reviewEfficacy outcome

    In adults with type 2 diabetes, liraglutide 1.2 mg per day reduced systolic blood pressure more than placebo.

    In plain wordsIn adults with type 2 diabetes, liraglutide 1.2 mg per day lowered systolic blood pressure more than placebo.

    Outcome
    DecreaseSystolic blood pressure change
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1.2 mg per dayAs given in this study (human).

    Measurements

    SBP mean difference
    −5.6 mmHg
    vs placebo, 1.2 mg

    Source sentences

    Summary
    In the 1.2 mg-treated group, liraglutide treatment reduced SBP compared with placebo and glimepiride treatment, with mean differences of -5.60 and -2.38 mmHg, and 95% CIs of -5.84 to -5.36, p < 0.00001 and -4.75 to -0.01, p = 0.05, respectively.
    1 context sentence
    Summary · context
    We searched the major databases for published or unpublished RCTs that had been performed in patients with T2DM and compared the effects of exenatide and liraglutide to those of other common drugs used to treat T2DM.
  2. 02HumanSystematic reviewEfficacy outcome

    In adults with type 2 diabetes, liraglutide 1.2 mg per day reduced systolic blood pressure more than glimepiride.

    In plain wordsIn adults with type 2 diabetes, liraglutide 1.2 mg per day lowered systolic blood pressure more than glimepiride did.

    Outcome
    DecreaseSystolic blood pressure change
    Study

    n: not reported in source

    Comparator
    Glimepiride
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1.2 mg per dayAs given in this study (human).

    Measurements

    SBP mean difference
    −2.38 mmHg
    vs glimepiride, 1.2 mg

    Source sentences

    Summary
    In the 1.2 mg-treated group, liraglutide treatment reduced SBP compared with placebo and glimepiride treatment, with mean differences of -5.60 and -2.38 mmHg, and 95% CIs of -5.84 to -5.36, p < 0.00001 and -4.75 to -0.01, p = 0.05, respectively.
    1 context sentence
    Summary · context
    We searched the major databases for published or unpublished RCTs that had been performed in patients with T2DM and compared the effects of exenatide and liraglutide to those of other common drugs used to treat T2DM.
  3. 03HumanSystematic reviewEfficacy outcome

    In adults with type 2 diabetes, liraglutide 1.8 mg per day reduced systolic blood pressure more than placebo.

    In plain wordsIn adults with type 2 diabetes, liraglutide 1.8 mg per day lowered systolic blood pressure more than placebo.

    Outcome
    DecreaseSystolic blood pressure change
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1.8 mg per dayAs given in this study (human).

    Measurements

    SBP mean difference
    −4.49 mmHg
    vs placebo, 1.8 mg

    Source sentences

    Summary
    In the 1.8-mg-treated group, liraglutide also reduced SBP compared with placebo and glimepiride treatment with mean differences of -4.49 and -2.62 mmHg, and a 95% CI of -4.73 to -4.26, p < 0.00001, and -2.91 to -2.33, p < 0.00001, respectively.
    1 context sentence
    Summary · context
    We searched the major databases for published or unpublished RCTs that had been performed in patients with T2DM and compared the effects of exenatide and liraglutide to those of other common drugs used to treat T2DM.
  4. 04HumanSystematic reviewEfficacy outcome

    In adults with type 2 diabetes, liraglutide 1.8 mg per day reduced systolic blood pressure more than glimepiride.

    In plain wordsIn adults with type 2 diabetes, liraglutide 1.8 mg per day lowered systolic blood pressure more than glimepiride did.

    Outcome
    DecreaseSystolic blood pressure change
    Study

    n: not reported in source

    Comparator
    Glimepiride
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1.8 mg per dayAs given in this study (human).

    Measurements

    SBP mean difference
    −2.62 mmHg
    vs glimepiride, 1.8 mg

    Source sentences

    Summary
    In the 1.8-mg-treated group, liraglutide also reduced SBP compared with placebo and glimepiride treatment with mean differences of -4.49 and -2.62 mmHg, and a 95% CI of -4.73 to -4.26, p < 0.00001, and -2.91 to -2.33, p < 0.00001, respectively.
    1 context sentence
    Summary · context
    We searched the major databases for published or unpublished RCTs that had been performed in patients with T2DM and compared the effects of exenatide and liraglutide to those of other common drugs used to treat T2DM.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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