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Study · Animal study (in vivo) · rat · 2012

5 results

Metabolism of growth hormone releasing peptides.

Thomas A, Delahaut P, Krug O, Schänzer W, Thevis M

Analytical chemistry13 Nov 2012Cited by 42 (Europe PMC)

PMID23101768 (opens in a new tab)DOI10.1021/ac302034w (opens in a new tab)PepBankPUB-23101768
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, at least three urinary metabolites were identified for each GHRP, including ipamorelin, and main metabolites were confirmed in a human in vitro model.

    In plain wordsIn rats, ipamorelin and related peptides broke down into several urine products; the main ones also formed in human lab tests.

    Peptide
    Ipamorelin
    Outcome
    Not applicableUrinary metabolites identified
    Study

    ratn: not reported in source

    rats (oral and intravenous), with human serum and recombinant amidase in vitro
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · po and ivAs given in this study (rat).

    Source sentences

    Summary
    Overall, 28 metabolites (at least three for each GHRP) were identified from the in vivo samples and main metabolites were confirmed by the human in vitro model.
    1 context sentence
    Summary · context
    Therefore, a comprehensive in vivo (po and iv administration in rats) and in vitro (with human serum and recombinant amidase) study was performed in order to generate information on urinary metabolites potentially useful for routine doping controls.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats given GHRP‑2 orally and intravenously, at least three urinary metabolites were identified, and main metabolites were confirmed in a human in vitro model.

    In plain wordsIn rats, at least three urinary breakdown products of GHRP‑2 were found, and the main ones were confirmed in lab tests with human serum.

    Peptide
    GHRP-2
    Outcome
    Not applicableUrinary metabolites identified
    Study

    ratn: not reported in source

    Rats (in vivo) with human serum and recombinant amidase (in vitro)
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oral and intravenousAs given in this study (rat).

    Source sentences

    Summary
    Overall, 28 metabolites (at least three for each GHRP) were identified from the in vivo samples and main metabolites were confirmed by the human in vitro model.
    1 context sentence
    Summary · context
    Therefore, a comprehensive in vivo (po and iv administration in rats) and in vitro (with human serum and recombinant amidase) study was performed in order to generate information on urinary metabolites potentially useful for routine doping controls.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rats given hexarelin orally and intravenously, at least three urinary metabolites were identified, and main metabolites were confirmed in a human in vitro model.

    In plain wordsIn rats, at least three urinary breakdown products of hexarelin were found, and the main ones were confirmed in lab tests with human serum.

    Peptide
    Hexarelin
    Outcome
    Not applicableUrinary metabolites identified
    Study

    ratn: not reported in source

    Rats (in vivo) with human serum and recombinant amidase (in vitro)
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oral and intravenousAs given in this study (rat).

    Source sentences

    Summary
    Overall, 28 metabolites (at least three for each GHRP) were identified from the in vivo samples and main metabolites were confirmed by the human in vitro model.
    1 context sentence
    Summary · context
    Therefore, a comprehensive in vivo (po and iv administration in rats) and in vitro (with human serum and recombinant amidase) study was performed in order to generate information on urinary metabolites potentially useful for routine doping controls.

Studies that did not test the peptide alone2

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 04AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Mechanism

    In rats and human in vitro models, all identified metabolites of the studied GHRPs, including GHRP‑2, formed through exopeptidase, amidase or endopeptidase activity.

    In plain wordsIn rats and lab tests, the breakdown products of these growth hormone releasing peptides, including GHRP‑2, came from peptide-cutting enzymes.

    Peptide
    GHRP-2
    Outcome
    Not applicableEnzyme activities forming metabolites
    Study

    ratn: not reported in source

    Rats (in vivo) with human serum and recombinant amidase (in vitro)
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    All identified metabolites were formed due to exopeptidase- (amino- or carboxy-), amidase-, or endopeptidase activity.
    1 context sentence
    Summary · context
    Therefore, a comprehensive in vivo (po and iv administration in rats) and in vitro (with human serum and recombinant amidase) study was performed in order to generate information on urinary metabolites potentially useful for routine doping controls.

    In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.

  2. 05AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Mechanism

    In rats and human in vitro models, all identified metabolites of the studied GHRPs, including hexarelin, formed through exopeptidase, amidase or endopeptidase activity.

    In plain wordsIn rats and lab tests, the breakdown products of these growth hormone releasing peptides, including hexarelin, came from peptide-cutting enzymes.

    Peptide
    Hexarelin
    Outcome
    Not applicableEnzyme activities forming metabolites
    Study

    ratn: not reported in source

    Rats (in vivo) with human serum and recombinant amidase (in vitro)
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    All identified metabolites were formed due to exopeptidase- (amino- or carboxy-), amidase-, or endopeptidase activity.
    1 context sentence
    Summary · context
    Therefore, a comprehensive in vivo (po and iv administration in rats) and in vitro (with human serum and recombinant amidase) study was performed in order to generate information on urinary metabolites potentially useful for routine doping controls.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 5 to 19Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Versions 3 to 4

    13 Oct 2026, 16:31 UTC

    The same notice was added 2 times, first on 13 Oct 2026, 16:31 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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