In acromegaly, 19% achieved a biochemical response after 4 weeks of pasireotide.
In plain wordsIn acromegaly, 19% achieved hormone control after 4 weeks of pasireotide.
- Peptide
- Pasireotide
- Outcome
- Not applicableBiochemical response after four weeks
- Study
n: not reported in source
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- 200-600 microg twice daily · subcutaneous · 4 weeksAs given in this study (human).
Measurements
- Biochemical response
- 19%
- pasireotide 200-600 microg bid, 4 weeks
Source sentences
After 4 wk of pasireotide 200-600 microg s.c. bid, 19% of patients achieved a biochemical response, which increased to 27% after 3 months of pasireotide; 39% of patients had a more than 20% reduction in pituitary tumor volume.
4 context sentences(design, population, supporting numbers)
We conducted a phase II, randomized, multicenter, open-label, three-way, crossover study.
Sixty patients with acromegaly, defined by a 2-h five-point mean GH level higher than 5 microg/liter, lack of suppression of GH to less than 1 microg/liter after oral glucose tolerance test, and elevated IGF-I for age- and sex-matched controls.
After treatment with octreotide 100 microg s.c. three times daily for 28 d, each patient received pasireotide 200, 400, and 600 microg s.c. twice daily in random order for 28 d.
A biochemical response was defined as a reduction in GH to no more than 2.5 microg/liter and normalization of IGF-I to age- and sex-matched controls.