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Study · In vitro (cells) · 2009

12 results

Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro.

Lesche S, Lehmann D, Nagel F, Schmid HA, Schulz S

The Journal of clinical endocrinology and metabolism11 Nov 2008Cited by 125 (Europe PMC)

PMID19001514 (opens in a new tab)DOI10.1210/jc.2008-1919 (opens in a new tab)PepBankPUB-19001514
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In receptor-expressing kidney cells, pasireotide was less potent than octreotide at inducing sst2 internalization.

    In plain wordsIn cells, pasireotide triggered sst2 receptor entry less potently than octreotide.

    Peptide
    Pasireotide
    Outcome
    Decreasesst2 internalization
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we show that SOM230 was less potent than octreotide in inducing internalization and signaling of sst2 receptors expressed in human embryonic kidney cells.
  2. 02LabIn vitro (cells)Mechanism

    In receptor-expressing kidney cells, pasireotide was less potent than octreotide at inducing sst2 signaling.

    In plain wordsIn cells, pasireotide triggered sst2 signaling less potently than octreotide.

    Peptide
    Pasireotide
    Outcome
    Decreasesst2 signaling
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we show that SOM230 was less potent than octreotide in inducing internalization and signaling of sst2 receptors expressed in human embryonic kidney cells.
  3. 03LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide was more potent than octreotide at inducing sst3 internalization.

    In plain wordsIn cells, pasireotide triggered sst3 receptor entry more potently than octreotide.

    Peptide
    Pasireotide
    Outcome
    Increasesst3 internalization
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, SOM230 was more potent than octreotide in inducing internalization and signaling of sst3 and sst5 receptors.
    1 context sentence
    Summary · context
    Here we show that SOM230 was less potent than octreotide in inducing internalization and signaling of sst2 receptors expressed in human embryonic kidney cells.
  4. 04LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide was more potent than octreotide at inducing sst3 signaling.

    In plain wordsIn cells, pasireotide triggered sst3 signaling more potently than octreotide.

    Peptide
    Pasireotide
    Outcome
    Increasesst3 signaling
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, SOM230 was more potent than octreotide in inducing internalization and signaling of sst3 and sst5 receptors.
    1 context sentence
    Summary · context
    Here we show that SOM230 was less potent than octreotide in inducing internalization and signaling of sst2 receptors expressed in human embryonic kidney cells.
  5. 05LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide was more potent than octreotide at inducing sst5 internalization.

    In plain wordsIn cells, pasireotide triggered sst5 receptor entry more potently than octreotide.

    Peptide
    Pasireotide
    Outcome
    Increasesst5 internalization
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, SOM230 was more potent than octreotide in inducing internalization and signaling of sst3 and sst5 receptors.
    1 context sentence
    Summary · context
    Here we show that SOM230 was less potent than octreotide in inducing internalization and signaling of sst2 receptors expressed in human embryonic kidney cells.
  6. 06LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide was more potent than octreotide at inducing sst5 signaling.

    In plain wordsIn cells, pasireotide triggered sst5 signaling more potently than octreotide.

    Peptide
    Pasireotide
    Outcome
    Increasesst5 signaling
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, SOM230 was more potent than octreotide in inducing internalization and signaling of sst3 and sst5 receptors.
    1 context sentence
    Summary · context
    Here we show that SOM230 was less potent than octreotide in inducing internalization and signaling of sst2 receptors expressed in human embryonic kidney cells.
  7. 07LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide stimulated rapid sst3 receptor down-regulation, as did octreotide.

    In plain wordsIn cells, pasireotide rapidly reduced sst3 receptors, as did octreotide.

    Peptide
    Pasireotide
    Outcome
    Decreasesst3 down-regulation
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both SOM230 and octreotide stimulated a rapid down-regulation of sst3 but not of sst2 or sst5 receptors.
  8. 08LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide did not stimulate sst2 receptor down-regulation, as also reported for octreotide.

    In plain wordsIn cells, pasireotide did not reduce sst2 receptors, as also reported for octreotide.

    Peptide
    Pasireotide
    Outcome
    No significant changesst2 down-regulation
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both SOM230 and octreotide stimulated a rapid down-regulation of sst3 but not of sst2 or sst5 receptors.
  9. 09LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide did not stimulate sst5 receptor down-regulation, as also reported for octreotide.

    In plain wordsIn cells, pasireotide did not reduce sst5 receptors, as also reported for octreotide.

    Peptide
    Pasireotide
    Outcome
    No significant changesst5 down-regulation
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both SOM230 and octreotide stimulated a rapid down-regulation of sst3 but not of sst2 or sst5 receptors.
  10. 10LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide and octreotide produced different patterns of sst2-stimulated beta-arrestin mobilization.

    In plain wordsIn cells, pasireotide and octreotide produced different patterns of beta-arrestin movement after sst2 stimulation.

    Peptide
    Pasireotide
    Outcome
    Not applicablesst2 beta-arrestin mobilization
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SOM230 and octreotide profoundly differed in their patterns of sst2-stimulated beta-arrestin mobilization.
  11. 11LabIn vitro (cells)Mechanism

    In receptor-expressing cells, pasireotide produced unstable receptor complexes that dissociated near the plasma membrane, unlike the stable complexes with octreotide.

    In plain wordsIn cells, pasireotide produced unstable receptor complexes near the cell surface, unlike the stable complexes with octreotide.

    Peptide
    Pasireotide
    Outcome
    DecreaseReceptor complex stability
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Whereas octreotide-mediated receptor activation led to the formation of stable complexes facilitating the internalization of sst2 and beta-arrestin-2 into the same endocytic vesicles, SOM230-mediated receptor activation led to the formation of unstable complexes that dissociated at or near the plasma membrane.
  12. 12LabIn vitro (cells)Mechanism

    In receptor-expressing cells, sst2 receptors recycled rapidly after pasireotide exposure but not after octreotide exposure.

    In plain wordsIn cells, sst2 receptors rapidly returned to the cell surface after pasireotide exposure but not after octreotide exposure.

    Peptide
    Pasireotide
    Outcome
    Increasesst2 recycling
    Study

    humann: not reported in source

    Cells expressing human somatostatin receptors
    Comparator
    Octreotide
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Consequently, sst2 receptors recycled rapidly to the plasma membrane after endocytosis in SOM230-treated cells, but not in octreotide-treated cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:36 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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