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Study · Animal study (in vivo) · mouse · 2009

7 results

Comparison of the effects of peripherally administered kisspeptins.

Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A

Regulatory peptides10 Oct 2008Cited by 55 (Europe PMC)

PMID18940206 (opens in a new tab)DOI10.1016/j.regpep.2008.10.001 (opens in a new tab)PepBankPUB-18940206
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male mice, systemic mouse kisspeptin‑10 increased serum testosterone in a dose-dependent way.

    In plain wordsIn adult male mice, mouse kisspeptin‑10 raised blood testosterone, with higher doses giving a larger rise.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum testosterone after mouse kisspeptin-10
    Study

    mousen: not reported in source

    Adult male mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · systemic · acuteAs given in this study (mouse).

    Source sentences

    Summary
    Mouse kisspeptin-10 and -52 dose-dependently increased serum testosterone
    1 context sentence
    Summary · context
    We examined the acute effect on serum levels of free testosterone in the adult male mouse after systemic administration of kisspeptins with different lengths of both human and mouse origin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult male mice, systemic human kisspeptin‑10 evoked a robust increase in serum testosterone, with the same potency as mouse kisspeptins.

    In plain wordsIn adult male mice, human kisspeptin‑10 raised blood testosterone as strongly as mouse kisspeptins.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum testosterone after human kisspeptin-10
    Study

    mousen: not reported in source

    Adult male mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · systemic · acuteAs given in this study (mouse).

    Source sentences

    Summary
    Human kisspeptin-10 and kisspeptin-54 evoked robust increase in serum testosterone, with the same potency as for mouse kisspeptins.
    1 context sentence
    Summary · context
    We examined the acute effect on serum levels of free testosterone in the adult male mouse after systemic administration of kisspeptins with different lengths of both human and mouse origin.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In adult male mice, the GnRH antagonist acyline totally blocked the effect of peripherally administered mouse kisspeptin‑10.

    In plain wordsIn adult male mice, a GnRH blocker fully stopped the testosterone rise caused by mouse kisspeptin‑10.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin-10-induced testosterone rise with GnRH antagonist acyline
    Study

    mousen: not reported in source

    Adult male mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · systemic · acuteAs given in this study (mouse).

    Source sentences

    Summary
    The effect of the peripherally administered mouse kisspeptin-10 could be totally blocked by the GnRH antagonist acyline.
    1 context sentence
    Summary · context
    We examined the acute effect on serum levels of free testosterone in the adult male mouse after systemic administration of kisspeptins with different lengths of both human and mouse origin.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In adult male mice, peripherally administered mouse kisspeptin‑10 had no effect on Fos induction in GnRH cells.

    In plain wordsIn adult male mice, mouse kisspeptin‑10 given outside the brain did not change Fos activation in GnRH cells.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeFos induction in GnRH cells
    Study

    mousen: not reported in source

    Adult male mice
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · systemic · acuteAs given in this study (mouse).

    Source sentences

    Summary
    Finally, peripherally administered mouse kisspeptin-10 had no effect on Fos induction in GnRH cells.
    1 context sentence
    Summary · context
    We examined the acute effect on serum levels of free testosterone in the adult male mouse after systemic administration of kisspeptins with different lengths of both human and mouse origin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In adult male mice, systemic human kisspeptin‑54 caused a robust increase in serum testosterone.

    In plain wordsIn male mice, human kisspeptin‑54 raised testosterone levels in the blood.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseSerum testosterone
    Study

    mousen: not reported in source

    adult male mouse
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · systemicAs given in this study (mouse).

    Source sentences

    Summary
    Human kisspeptin-10 and kisspeptin-54 evoked robust increase in serum testosterone, with the same potency as for mouse kisspeptins.
    1 context sentence
    Summary · context
    We examined the acute effect on serum levels of free testosterone in the adult male mouse after systemic administration of kisspeptins with different lengths of both human and mouse origin.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In adult male mice, human kisspeptin‑54 raised testosterone with the same potency as the mouse kisspeptins.

    In plain wordsIn male mice, human kisspeptin‑54 raised testosterone as potently as mouse kisspeptins.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changePotency on serum testosterone versus mouse kisspeptins
    Study

    mousen: not reported in source

    adult male mouse
    Comparator
    Mouse kisspeptins
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · systemicAs given in this study (mouse).

    Source sentences

    Summary
    Human kisspeptin-10 and kisspeptin-54 evoked robust increase in serum testosterone, with the same potency as for mouse kisspeptins.
    1 context sentence
    Summary · context
    We examined the acute effect on serum levels of free testosterone in the adult male mouse after systemic administration of kisspeptins with different lengths of both human and mouse origin.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In adult male mice, the longer kisspeptin forms acted more slowly, and the long human form (kisspeptin‑54) had a more prolonged effect.

    In plain wordsIn male mice, the long human kisspeptin form started more slowly and had a longer effect.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    MixedTime course of testosterone response
    Study

    mousen: not reported in source

    adult male mouse
    Comparator
    Shorter kisspeptins
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · systemicAs given in this study (mouse).

    Source sentences

    Summary
    Time-course experiments revealed that the longer forms had a slower onset of action, and the long human form also a more prolonged effect.
    1 context sentence
    Summary · context
    We examined the acute effect on serum levels of free testosterone in the adult male mouse after systemic administration of kisspeptins with different lengths of both human and mouse origin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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